DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tbc and CG12241

DIOPT Version :9

Sequence 1:	NP_001285494.1	Gene:	tbc / 318059	FlyBaseID:	FBgn0052506	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_650432.1	Gene:	CG12241 / 41834	FlyBaseID:	FBgn0038304	Length:	804	Species:	Drosophila melanogaster

Alignment Length:	486	Identity:	102/486 - (20%)
Similarity:	170/486 - (34%)	Gaps:	140/486 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   774 DEEDNKQKQQQDEKISE--SESKLPDYRKLEEQI--------NQEPSCSASTASSY------ETV 822
            |.|....:::...|:..  ||..|.:...:.|::        |.....||.|||.:      :..
  Fly    11 DHEGYVGREEHTRKLQNLGSEDDLGELPPMMEELSVADGLRPNPGGPFSALTASMWPQEILAKLG 75

  Fly   823 GPGEVHQRPNSDTRSVLSPEY--------LSADD---------LQLPDDEDAVRPPPPPAAAAVI 870
            |..|:...||.      .|||        :..:|         |.:|..|||.:.....|.....
  Fly    76 GGAELASGPND------QPEYRFDEFGFRVEEEDGPEQSSNKLLSIPFVEDAQQRLQWIAHLEFS 134

  Fly   871 ITKASVDITNWERSPKAAEGDQMSPLEEQAGESGGAGVN-----------MDALQQPKSACAS-- 922
            ..|.:.:: :||..      |.|.|..|:.......|:.           ..||.:.:.:..|
  Fly   135 HNKEAAEL-SWEHV------DVMLPRTEKLRNMVRQGIPHTLRAQMWMRLSGALAKKQKSETSYH 192

  Fly   923 ---PASSNGGVYSSELLEQFGLNLHRIEKDVQRCDRNYWYFANEN---LDKLRNVISTYVWEHLD 981
               .||||..:.:|:          :||||:.|.......|:|.|   :.:||.::....|...|
  Fly   193 DIVKASSNDQLMTSK----------QIEKDLLRILPTNACFSNPNGTGIPRLRRILRGIAWLFPD 247

  Fly   982 VGYMQGMCDLVAPLLVIFDDESLSYSCFCKLMERMIE-----NFPSGGAMDMHFANMRSLIQILD 1041
            :||.||...:||.||:..::|:..:     :|..::|     ::.|...:.:. |:.|.:..::.
  Fly   248 IGYCQGTGVIVACLLLFMEEENAFW-----MMATIVEDLLPASYYSSTLLGIQ-ADQRVMHTLIA 306

  Fly  1042 SEMYDLMDS--NGDYTHFYFCYRWFLLDFKRELVYDDVFATWEVIWAAKHIASGHFVLF-LALAL 1103
            :.:..:.:|  ..|.........|||..|...:....:...|:  |   ....|..||| |.|.:
  Fly   307 NYLSSVDESLRKHDIELSLITLHWFLTLFANVVHMKILVRIWD--W---FFYEGSIVLFQLTLGM 366

  Fly  1104 LETYRDII--LSNSM-----------DFTDVIKFFNEMAE---------------RHNAQSVL-- 1138
            |:.....:  |.||.           :.|||...|.:..|               ||.|..:.
  Fly   367 LKVKEQDLKHLENSAQIFNSLSDIPGEVTDVEVLFRQALEVGGSLSQTVIDTHRRRHLAYLMADQ 431

  Fly  1139 ----------------QLARSLVLQLQMIIE 1153
                            ||||..|.:.:.|:|
  Fly   432 GHQIGNPEAAPNLPKQQLARRQVRKSKSILE 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_001285494.1	RUN	45..218	CDD:280855
		PH_RUTBC	292..466	CDD:275431
		TBC	923..1087	CDD:214540	39/173 (23%)
CG12241	NP_650432.1	TBC	161..375	CDD:214540	50/234 (21%)
		SH3_SGSM3	540..592	CDD:212747
		RUN	619..773	CDD:280855
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456619
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22957
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.930