Protein Alignment tbc and CG42795

DIOPT Version :10

• Sequence 1: NP_608395.6
• Gene: tbc / 318059
• FlyBaseID: FBgn0052506
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: NP_001287272.1
• Gene: CG42795 / 41252
• FlyBaseID: FBgn0261928
• Length: 3213
• Species: Drosophila melanogaster
• Alignment Length: 1234
• Identity: 222/1234 - (17%)
• Similarity: 376/1234 - (30%)
• Gaps: 371/1234 - (30%)

  Fly    18 SVKKEVKQLME----------------------EAVTKKYVHEESSSVTSLCGAVEACLSQGLRR 60
            |.:|:.|:|.|                      .::||:....||||.|.:....|...|....:
  Fly  1063 SAEKQRKELSEMEAEYPIKSERIPSTADLESRFNSLTKQMSSSESSSKTPIDLKDEDRPSGSSSK 1127

  Fly    61 RALGLFKTSSTTALLH------------------------KIAKSCPEAEHISKLVQEIEASD-- 99
            ..    |.|..|:.||                        ||.:...|...|.||....|..|
  Fly  1128 NQ----KDSEKTSKLHKSEEPESNTKETTGETEASDSNDSKIGEKETEQPRIKKLPSTAELEDRF 1188

  Fly   100 ------PSKRSSSSSDSFQRPPMLKKSSS----NSMSTGTNAAASTSSASASISVSASTSSMSLA 154
                  .|.:.||.|.:.:.||..::|.|    ........|...||.....|:...|..|..
  Fly  1189 NALERKMSVQKSSPSKNKKEPPDEEESKSTKEPEEPEESEKANEKTSGRQTPIAKKDSKDSDQ-- 1251

  Fly   155 SMKYLWIRLALYEKRLTKIIEYLVSNASSFYDRDSLVADSDYGSILSSLLVGPCALEFTRAKTAD 219
                        :|..||      .|.|...::|..|.           :..|.:.|....:|:.
  Fly  1252 ------------KKSETK------ENQSPTKNQDEKVK-----------VKSPKSEEMIEKETSS 1287

  Fly   220 HYWTDPHADELVQRHRISSCRRSSSTCSRPAI---------------INFKRSLNTSSDEAGTGS 269
            :...|.|..|.....::...|..||......|               ...|.:....|.:.|...
  Fly  1288 NPKEDSHESEAATNKKVEGNRELSSEKGDHKIKEKSEEAPGKAGKETAETKNANVKDSSKKGDSQ 1352

  Fly   270 FKSIASASVAK---DYVESLHQNAKATLLYGKNNVQVLPKDVAEPMPGYLSLHQHIQTLTIKWT- 330
            ....|..||::   |...|..:|:.:.....:...:..|....|....:.:|.:.:.|..::.|
  Fly  1353 KNEAAKTSVSQTESDLKPSSKENSTSKDAEQEKTPRKSPPSTEELEKRFNALEKQMSTTNLETTK 1417

  Fly   331 -PNQ----LMNGYTEAEEAEDIDKDAFWAYALNINVDEIVYVHCHQSRGEDSGGTVILVGQDGVQ 390
             |:|    ..:..|.||........:|......:|    |.:...|||.|      :.|..:..:
  Fly  1418 EPDQTKPATKSQSTSAEVKTQKSMKSFDDKIKEVN----VAIEKEQSRVE------VEVNAEKKR 1472

  Fly   391 RPPIHFPEG--GHMQQFLSCLETGLLPHGQLDPPLWSQRGIGKMFLWPRSMRRRILP--SVMESV 451
            :.....|:.  |..||.......|.......:||  |...:.|.:   .:::||:..  ...|:|
  Fly  1473 KNVEEAPKNKEGDSQQPEESQHKGKNQRRASEPP--STEDLEKRY---ETLKRRMSSKNQFSETV 1532

  Fly   452 DETPIDYVFRIVSKSRHEEFAATHSILDFVRSTPRRAQLSSCSTTGSSDCSNKSLSIDQF----- 511
            ||........::|::..|:           :..|....|.|.......|..|....:|:.
  Fly  1533 DEALERIQQEVISEAVEEK-----------KPPPSTEDLESRFEALHGDKKNVESKMDETKHVDV 1586

  Fly   512 ---------------PMESPLILQQQQQQQQQLLQAQSTSIEMVCSTMRRQIISRAFYGWLAYCR 561
                           |.|.|::.:....|||.|       ||.:.|.||.|....
  Fly  1587 AIEAHIPSPPPPPPPPKERPVLAEPVLHQQQAL-------IEELQSKMRGQSPGE---------- 1634

  Fly   562 HLSTVRTHLSGLVHGRITPEMK-----------ADE-----------EGLTKERWQL-------- 596
                     ..|....|.|:.:           .||           .....|:||.
  Fly  1635 ---------ENLKPSEINPQRRQKKLLQRPTPMGDETSEAPANTAYYRAANHEQWQQRMVRRFSD 1690

  Fly   597 LNVNGVLENATEFYRLVYFGGVQPELRQEVWPYLLGHYAFGSTTEDRKKQDETCKHYYETTMSEW 661
            |.....|||..:|            |.::::                       |.:|:    :.
  Fly  1691 LPSRADLENRLQF------------LERQLY-----------------------KKFYK----QR 1716

  Fly   662 LAVDAIVQQREKEKTARAVAKLSSGSNSGNDRTVRAADLEAGGDLENEVFEDISDISDPGDLEFD 726
            .|.|:.|..|         .||.........|..|..  ||.|.||..|......:|: ..|:..
  Fly  1717 CASDSEVASR---------VKLPPEDQPSTSRQARKQ--EAEGQLEQRVLALEKQLSE-NSLKLL 1769

  Fly   727 EQQQQQQQQAECAVSGNHLTVKPIPRAMKTSTDSGHVDESFNELDEPD---------------EE 776
            |..:::.:.|:.:.|...|:.:.|.   .|..:.....::..||:|.|               .:
  Fly  1770 EAMRERHRSADDSGSPRRLSTETID---ATGKELVRYTQNIGELEEVDAHKPINISINIKMMVNK 1831

  Fly   777 DNKQKQQQDEKISESESKLPDYRKLEEQINQEPSCSASTASSYETV--GPGEVH-------QRPN 832
            |::.||.:.|....:|.......:||:|:.:|.:.:.|.....|.:  .|.::.       |..|
  Fly  1832 DSESKQPKGESKPTTEDLTRRLEQLEQQLLEERAKNGSIPPENEVLEEKPEKLEEKDSCKKQEKN 1896

  Fly   833 SDTRSVLSPEYLSADDLQLPDDEDAVRPPPPPAA---------------AAVIITKASVDITNWE 882
            ...:.|...|   .:..::|.|    |...|.:|               |.|:.|:.||...|..
  Fly  1897 CHNQHVKGDE---VEKTEIPAD----RKIEPASAKETKTLENVEKAQTRAKVVDTEKSVKDQNAV 1954

  Fly   883 RSPKAAEGDQMSPLEEQA--------GESGGAGVNMD----------------ALQQPKSACASP 923
            ...|:.: ||...::::|        .:|..||.:.|                |.:.||:..:..
  Fly  1955 TDEKSVQ-DQNVVVDKKADRKILDKKDKSPAAGKSEDTKQTSGKKEKSEDIKQASEAPKAGASKE 2018

  Fly   924 ASSNGGVYSSEL---------LEQFGLNLHRIEKDVQRCDRNYWYFANENLDKLRNVISTYVWEH 979
            .|:.|....::|         |::.......:|.:..:...|..........|....::....|
  Fly  2019 TSTRGKPSETKLEKPTTKESVLKETFPKKENLESEKPKSKENEATKTETQKSKETPTVAVSPKE- 2082

  Fly   980 LDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKLMERMIENFPSGGAMDMHFANMRSLIQILDSE 1043
                      ..|:...:....|::..|...:|.|:|:.|....|.||   .|.::::.::|:|
  Fly  2083 ----------SKVSSKQMTEKKETIKDSSSKELPEKMVINSTDVGPMD---PNGKTVVLLMDNE 2133

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_608395.6	RUN_SGSM1_like	21..214	CDD:439049	49/250 (20%)
		PH_RUTBC	292..466	CDD:275431	34/183 (19%)
		TBC	923..1087	CDD:214540	21/130 (16%)
CG42795	NP_001287272.1	RabGAP-TBC	268..443	CDD:459855
		DUF4682	560..689	CDD:464830
		PTZ00121	<1112..2009	CDD:173412	187/1045 (18%)
		PTZ00121	<1740..2340	CDD:173412	78/422 (18%)
		PTZ00449	<2270..2610	CDD:185628