Protein Alignment tbc and Tbc1d8-9

DIOPT Version :10

• Sequence 1: NP_608395.6
• Gene: tbc / 318059
• FlyBaseID: FBgn0052506
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: NP_649305.1
• Gene: Tbc1d8-9 / 40361
• FlyBaseID: FBgn0037074
• Length: 1291
• Species: Drosophila melanogaster
• Alignment Length: 661
• Identity: 120/661 - (18%)
• Similarity: 219/661 - (33%)
• Gaps: 222/661 - (33%)

  Fly   628 PYLLGH----------YAFGSTTEDRKKQDETCKHYYETTMSEWLAVDAI----VQQREKEKTAR 678
            ||.:.|          .|.|.|      |||..|.:      |||..:..    ..:.|.|.|..
  Fly    56 PYRILHQTPSSEVSYEIAIGIT------QDEIVKDW------EWLKANLFKVLDEMENEDEVTNF 108

  Fly   679 AVAKLSSGSNSGN-DRTVRAADLEAGGDLENEVFEDISDISDPGDLEFDEQ----------QQQQ 732
            .:.|:.|.....| |.|..:||.:.......::|:          :..:|:          :.:.
  Fly   109 TICKIQSLYTQNNQDDTGESADFKVMKSKFRQIFK----------MPEEERLVISYSATYVKNKI 163

  Fly   733 QQQAECAVSGNHL---------TVKPIPR--------------AMKT-------------STDSG 761
            .:|.:..:|.||:         .:|.|.|              .:||             ::|:.
  Fly   164 PRQGQLYISLNHVCFYSYMLGQEIKRIIRFAELEDISRNANTIYLKTTNNMTYNFTMLFNASDAH 228

  Fly   762 HVDESFNE------LDEPD----EEDNKQKQQQDEKISESESKLPD------------YRKLEEQ 804
            .:.|..|:      :.:||    :.|.....:...|.|:....|.|            |.:|.:.
  Fly   229 LLIEQLNKMAIQQLIHDPDSPVVDHDTSNFSRLGSKTSKKPVLLRDLTARQKSEEFRIYFRLPQS 293

  Fly   805 INQEPSCSASTASSY-ETVGPGEVHQRPN-----SDTRSVLS--------PEYLSADDLQLPDDE 855
            ...:....|:..:.| :....|.::..||     ||.:.::|        ......||.|...:.
  Fly   294 EIIDGKIKANIWTPYSKRFNSGFIYLSPNFFCFRSDVKDLVSVVIPMKTIKSVEKKDDGQQRFEN 358

  Fly   856 DAV----RPPPPPAA----AAVIITK----------------ASVDITNWER------------S 884
            ..|    ...|...|    .||:|:|                |..|| :|.:            |
  Fly   359 QIVIITSENVPFMFAHIVDRAVLISKITDLLARVHVPLSRERAKYDI-SWSKQTALMNTFKTQFS 422

  Fly   885 PKAAEGDQMSPLEEQAG-ESGGAGVNM---------------DALQQP----KSACASPASSNGG 929
            .:..:..:...:..:|. ...|.|:.|               |.|:|.    .|........|.|
  Fly   423 AEIIQKQEEKMVRWEAHFRDFGRGIGMFRTTDVINLIVEGIPDKLRQEIWLIFSGAIHDKEMNPG 487

  Fly   930 VYSSELLEQFGLNLH-----RIEKDVQRCDRNYWYF-ANENLDKLRNVISTYVWEHLDVGYMQGM 988
            :| .:|:|:.....:     .|::|:.|....:..| :.:.:..||.|:..|...:..|||.|.|
  Fly   488 LY-EDLVEKAACIKNCFAHDEIDRDLPRSLPEHPAFQSTDGIGALRRVLQAYALRNPQVGYCQAM 551

  Fly   989 CDLVAPLLVIFDDESLSYSCFCKLMERMIENFPS----GGAMDMHFANMRSLIQILDSEMYDLMD 1049
             ::|:.:.::|.||..::.....|.|.::.::..    |..:|....|     :::::.:.||
  Fly   552 -NIVSSVFLLFCDEENAFWMLASLCENLLPDYYKDKVVGAQIDQGVLN-----ELVETHLPDL-- 608

  Fly  1050 SNGDYTHF-------YFCYRWFLLDFKRELVYDDVFATWEVIWAAKHIASGHF------VLFLAL 1101
                :.|.       .....|||..|...:.|:          ::.||....|      :..::|
  Fly   609 ----HGHLEQLGVIKMISISWFLTIFMSVISYE----------SSLHILDCFFYEGAKIIFMISL 659

  Fly  1102 ALLETYRDIIL 1112
            .::|..||.:|
  Fly   660 QIIEWNRDKLL 670

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_608395.6	RUN_SGSM1_like	21..214	CDD:439049
		PH_RUTBC	292..466	CDD:275431
		TBC	923..1087	CDD:214540	35/180 (19%)
Tbc1d8-9	NP_649305.1	PH-GRAM1_TCB1D8_TCB1D9_family	147..249	CDD:275404	15/101 (15%)
		PH-GRAM2_TCB1D9_TCB1D9B	293..389	CDD:270161	18/95 (19%)
		TBC	462..670	CDD:214540	46/230 (20%)