DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tbc and GAPsec

DIOPT Version :9

Sequence 1:	NP_001285494.1	Gene:	tbc / 318059	FlyBaseID:	FBgn0052506	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_648245.2	Gene:	GAPsec / 38987	FlyBaseID:	FBgn0035916	Length:	403	Species:	Drosophila melanogaster

Alignment Length:	423	Identity:	87/423 - (20%)
Similarity:	157/423 - (37%)	Gaps:	123/423 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   779 KQKQQQDEKISESESKLPDYRKLEE-QINQEPSCSASTASSYET----VGPGEVHQRPNSDTRSV 838
            |.:.::.|.:......|.|.::|.: ..|..|...:..|.|::.    :||     |.:|.|.::
  Fly     5 KARVKEFEDVLAGPQDLIDLKQLRKLAFNGVPDVQSFRALSWKLLLGYLGP-----RRSSWTTTL 64

  Fly   839 LSPEYLSADDLQLPDDEDAVRPPPPPAAAAVIITKASVDITNWERSPKAAEGDQMSPLEEQAGES 903
            .....|....:     |:.|.||...:      .:||||         ..:||::        :|
  Fly    65 AQKRALYKQFI-----EELVLPPGHSS------NRASVD---------GGDGDKV--------DS 101

  Fly   904 GGAGVNMDALQQ-PKSA-----------------------------------CASPASSNG---- 928
            ||.|:....|.: |:||                                   |.....|.|
  Fly   102 GGVGLQDHPLSEGPESAWNTFFNDNEFLLQIDKDVRRLCPDISFFQQPTDYPCEIVVHSKGEHGR 166

  Fly   929 --------GVYSSELLEQFGLNLHRIEKDVQRCDRNY----------WYFANENLDKLRNVISTY 975
                    .|.||..:|:.||.:.:|....:|...||          |       :.::.::..|
  Fly   167 RLHERVVPAVLSSANVERKGLGMTKINLITKRSVENYAAMEEGQEAHW-------EVVQRILFIY 224

  Fly   976 VWEHLDVGYMQGMCDLVAPL-LVIFDDESLSYS---------CFCKLMERMIENF-----PSGGA 1025
            ...:...||:|||.::|.|: .|:..|..|:|.         ||..||..:.:.|     .:.|.
  Fly   225 AKLNPGQGYVQGMNEIVGPIYYVMASDPDLTYRAHAEADCFFCFTALMSEIRDFFIKTLDDAEGG 289

  Fly  1026 MDMHFANMRSLIQILDSEMYDLMDSNGDYTHFYFCYRWFLLDFKRELVYDDVFATWEVIWAAKHI 1090
            :....|.:.::::..|..:|:|:.|...:.. |:.:||..|...:|....||...|:.::|.:.
  Fly   290 IKFMMARLSNMLKSKDLSIYELLRSQELHPQ-YYSFRWLTLLLSQEFPLPDVLRIWDSVFADEQ- 352

  Fly  1091 ASGHFVLFLALALLETYRDIILSNSMDFTDVIK 1123
             ...|::.:..:::...|:.||.|  ||...:|
  Fly   353 -RFDFLIKICCSMILIQREAILEN--DFASNVK 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_001285494.1	RUN	45..218	CDD:280855
		PH_RUTBC	292..466	CDD:275431
		TBC	923..1087	CDD:214540	44/200 (22%)
GAPsec	NP_648245.2	TBC	<191..373	CDD:214540	39/191 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456574
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22957
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840