Protein Alignment tbc and GAPcenA

DIOPT Version :9

• Sequence 1: NP_001285494.1
• Gene: tbc / 318059
• FlyBaseID: FBgn0052506
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: NP_001097549.1
• Gene: GAPcenA / 38945
• FlyBaseID: FBgn0035879
• Length: 1194
• Species: Drosophila melanogaster
• Alignment Length: 1216
• Identity: 193/1216 - (15%)
• Similarity: 352/1216 - (28%)
• Gaps: 519/1216 - (42%)

  Fly     5 NADGSDYKERLIASVK-----KEVKQLMEEAVTKKYVHEESSSVTSLCGAVEACLSQGLR----- 59
            |.:.||.:..:..::|     :.|....|::..:...|::.|....|.|:....:...:|
  Fly    79 NRNLSDMQHEMTDALKDLELERGVAASGEKSAQRLPSHQQKSLTLPLTGSGGGSVDPEMRFPCTL 143

  Fly    60 ---RRALGLFKTSSTTALLHKIAKSCPEAEHISKLVQEIEASDPSKRSSSSSD---------SFQ 112
               :....|...||:..:.|.:...|.:|.. :.:.::.:|..|.|..::..:         .|.
  Fly   144 FTPKSEETLDDASSSNRVGHSVFYDCIDASP-ACVEEKQDAMKPEKGDTTDEEVSEIDQGCTIFS 207

  Fly   113 RPPMLKKSSSNSMSTGTNA-------AASTSSASASISVSASTSSMSLASMKYLWIRLALYEKRL 170
            ....|..::.|:..:.|..       .:.:.|....|:||....|..|         :.|::...
  Fly   208 GVTYLGAANINAPKSETEVYRIMGELNSGSKSVGLKITVSIPNCSEGL---------VVLHDAES 263

  Fly   171 TKII-EYLVSNASSFYDRDSLVADSDYGSILSSLLVGPC------ALEFTRAKTADHYWTDPHAD 228
            ..|| .|.:|:...:|.                   ||.      ...||        |.  |.|
  Fly   264 NTIIATYEISSIILYYR-------------------GPVDTVENGCFAFT--------WL--HGD 299

  Fly   229 ELVQRH-----------RISSCRRS-------SSTCSRPAIINFKRSLNTSSDEAG----TGSFK 271
            .|.|.|           ::|:|.:.       |.:||..:.::...|:  :||.:|    |..::
  Fly   300 ALFQCHVFRCHIPEAVNQVSACFQKAFQTYPPSMSCSLNSAVDMANSV--TSDVSGNPLNTAGYE 362

  Fly   272 SIASASVAKDYVESLHQNAKATLLYGKNNVQVLPKDVAEPMPGYLSLHQHIQ---TLTIKWTPNQ 333
            .|.|..:.:              ...||:...:|:|     .|...|..:..   .:|:|.||:.
  Fly   363 FIVSLEIRE--------------RVAKNSYAAVPRD-----RGCFKLRANTDKEVCITVKQTPSN 408

  Fly   334 LMN--------GYTEAEEAEDIDKDAFWAYALNINVDEIVYVHCHQSRGEDSGGTVILVGQDGVQ 390
            ::.        |...|.....:.||...     |::..:.|:        ..|||.:....|
  Fly   409 VLQPLHIERCFGVLVAPGKLVVQKDMHL-----IDMHSMGYI--------QPGGTGVATESD--- 457

  Fly   391 RPPIHFPEGGHMQQFLSCLETGLLPHGQLDPPLWSQRGIGKMFLWPRSMRRRILPSVMESVDETP 455
                     .:.||..|                           ||
  Fly   458 ---------SNAQQSSS---------------------------WP------------------- 467

  Fly   456 IDYVFRIVSKSRHEEFAATHSILDFVRSTPRRAQLSSCSTTGSSDCSNKSLSID----------Q 510
              |..|...|::.:.|              .:..|.|..|       |.::::|          :
  Fly   468 --YTIRAEWKAQEKAF--------------EQLNLESSKT-------NLTVAVDIVMRRIQEPVR 509

  Fly   511 FPMESPLILQQQQQQQQQLLQAQSTSIEMVCSTMRRQIISRAFYGWLAYCRHLSTVRTHLSGLVH 575
            |.:|:|:.:|            .::.:.::...|.::.::..||      .||.  ||..|....
  Fly   510 FVIETPVTIQ------------SASEMRIMDHFMSKRPMTLRFY------LHLK--RTEESNWKV 554

  Fly   576 GRITPEMKADEEGLTKERWQLLNVNGVLENATEFYRLVYFGGVQPELRQEV-----WPYLLGHYA 635
            ..|.|..:..|:...::...||.:.  :.|.:...|......::.:...:.     .|.|.|
  Fly   555 NSIDPSEEITEQPGHQQSSSLLKMG--MNNLSRIVRSSSIASIEDDCPSDYSSDGDEPLLSG--- 614

  Fly   636 FGSTTEDRKKQDETCKHYYETTMSEWLAVDAIVQQREKEKTARAVAKLSSGSNSGNDRTVRAADL 700
                      ..|..|...:.|:.||   |.|:::.:.||..:.:|.|           ||....
  Fly   615 ----------TGEVSKDCSQDTLDEW---DPILREWDSEKRPKNLAPL-----------VRLGVP 655

  Fly   701 EAGGDLENEVFEDISDISDPGDLEFDEQQQQQQQQAECAVSGNHLTVKPIPRAMKTSTDSGHVDE 765
            ||   |..::::.::::.  |.:|.:::
  Fly   656 EA---LREKIWQKLANVE--GRMEMNDK------------------------------------- 678

  Fly   766 SFNELDEPDEEDNKQKQQQDEKISESESKLPDYRKLEEQINQEPSCSASTASSYETVGPGEVHQR 830
                                            |:.|   |.:|..|        |||...::|
  Fly   679 --------------------------------YKIL---ITKETKC--------ETVIQRDIH-- 698

  Fly   831 PNSDTRSVLSPEYLSADDLQLPDDEDAVRPPPPPAAAAVIITKASVDITNWERSPKAAEGDQMSP 895
                                                                         :..|
  Fly   699 -------------------------------------------------------------RTFP 702

  Fly   896 LEEQAGESGGAGVNMDALQQPKSACASPASSNGGVYSSELLEQFGLNLHRIEKDVQRCDRNYWYF 960
            ..:...|.||:|  .|||.:...|.|        |:.||
  Fly   703 AHKCFKEIGGSG--QDALFKVSKAYA--------VHDSE-------------------------- 731

  Fly   961 ANENLDKLRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKLMERMIENFPSGGA 1025
                                 |||.||:..:.|.||:...:|    ..||.|:..|.:.    |.
  Fly   732 ---------------------VGYCQGLSFIAASLLLHMPEE----DAFCVLVALMYDY----GL 767

  Fly  1026 MDMHFA----------NMRSLIQILDSEMYDLMDSNGDYTHFYFCYRWFLLDFKRELVYDDVFAT 1080
            .|::.|          .:..||:....::::...:.|..||.| ..:|||..:........||..
  Fly   768 RDLYKAGFEVLYLRLYQLERLIKDQLPKLHEHFTACGIETHMY-ASQWFLTLYTARFPLCFVFHV 831

  Fly  1081 WEVIWAAKHIASGHFVLF-LALALLETYRDIILSNSMDFTDVIKFF 1125
            .:|.     :..|..||| :|:.||......:  ..:||..::|:|
  Fly   832 LDVF-----LLDGLPVLFQVAVTLLSICESDL--RQLDFEGILKYF 870

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_001285494.1	RUN	45..218	CDD:280855	32/203 (16%)
		PH_RUTBC	292..466	CDD:275431	27/184 (15%)
		TBC	923..1087	CDD:214540	31/173 (18%)
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922	28/165 (17%)
		DUF3694	429..523	CDD:289256	26/199 (13%)
		TBC	650..858	CDD:214540	64/426 (15%)
		Phage_Gp23	<914..991	CDD:287621

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456585
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22957
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.930