DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tbc and Tbc1d2

DIOPT Version :9

Sequence 1:	NP_001285494.1	Gene:	tbc / 318059	FlyBaseID:	FBgn0052506	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	XP_006538109.1	Gene:	Tbc1d2 / 381605	MGIID:	2652885	Length:	923	Species:	Mus musculus

Alignment Length:	971	Identity:	184/971 - (18%)
Similarity:	328/971 - (33%)	Gaps:	239/971 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   243 SSTCSRPAIINFKRSLNTSSDEAGTGSFKSIASASVAKDYVESLHQNAKATLLYGKNNVQVLPKD 307
            |..|:||.....|:.....|...|.|..|.......       .:...|..|.|.:......|.|
Mouse    32 SEGCARPLDTVPKKLCGYLSKFGGKGPIKGWKCRWF-------FYDERKCHLYYSRTAQDANPLD 89

  Fly   308 VAEPMPGYLSLHQHIQ---TLTIKWTPNQLMNGYTEAEEAEDIDKDAFWAYALNINVDEIVYVHC 369
            ..:............:   |..|| ||::::......::|.     .:|...|.:...|.
Mouse    90 SIDLSSAVFDCKADAEEEGTFEIK-TPSRVITLKAATKQAM-----LYWLQQLQMKRWEF----- 143

  Fly   370 HQSRGEDSGGTVILVGQDGVQRPPIHF---PEGGHMQQFLSCLE--TGLL-PHGQLDPPLWSQRG 428
            |.|...........:.::|   |.:|.   .|...:::||..::  |||: ....|.|
Mouse   144 HNSPPALPATPAAALAENG---PTLHLKLEQEEAELEEFLCPVKTPTGLVGAAAALQP------- 198

  Fly   429 IGKMFLWPRSMRRRILPSVMESVDETPIDYVFRIVSKSRH------EEFAATHSILDFVRSTPRR 487
                           :|:|..::....:.::...:..:.|      :..||.|..|  |..:|:.
Mouse   199 ---------------VPAVPSALQNISLKHLGTEIQNTMHNIRGNKQAQAAAHGPL--VEDSPQG 246

  Fly   488 AQLSSCSTTGSSDCSNKSLSIDQFPMESPLILQQQQQQQQQLLQAQSTSIEMVCS----TMRRQI 548
            .:..|......||   .||..::.| |.|               |:|.....|.|    ..:||.
Mouse   247 GEPQSGEQPSISD---PSLPAEKEP-EDP---------------AKSAPRSSVPSGPTQKPKRQS 292

  Fly   549 ISRAFYGWLAYCRHLSTVRTHLSGLVHGRITPEMKADEEG----LTKERWQLLNVNGVLENATEF 609
            .:..|:.               .||...|...|..|..|.    ||||......:..:|..|.|
Mouse   293 NTFPFFS---------------DGLARSRTAQEKVAALEQQVLMLTKELKSQKELVIILHKALE- 341

  Fly   610 YRLVYFGGVQPELRQEVWPYLLGHYAFGSTTEDRKKQDETCKHYYETTMSEWLAVDAIVQQRE-- 672
                   ..|.|.|        ...|:.:.||||.:. |..:|...........|:|:.|.||
Mouse   342 -------AAQQEKR--------ASSAYLAATEDRDRL-ELVRHKVRQIAELNQRVEALEQGRERL 390

  Fly   673 ------KEKTARAV---AKLSSGSNSGNDRTVRAADLEAGGDLENEVFEDISDISDPGDLEFDEQ 728
                  :|:..:|:   .:|....|....:.:        ..|..::.||::..:|..:.:|..|
Mouse   391 AHEAGLREQQVQALQQHVQLLMDKNHAKQQVI--------CKLTQKLTEDLAQPADATNGDFLSQ 447

  Fly   729 QQQQQQQAECAVSGNHLTVKPIPRAMKT-----STDSGHVDESFNELDEPDEEDNKQKQQQDEKI 788
            |::.:          ||  |....|.:|     :::...|.:.:.::.|.::....:......:.
Mouse   448 QERME----------HL--KDDMEAYRTQNRFLNSEIHQVTKIWRKVAEKEKALLTKCAYLQARN 500

  Fly   789 SESESK-LPDYRKLEE--------------QINQE---------PSCSASTASSYETVGPGEVHQ 829
            .:.||| |...|:|:|              |:.||         .|...|..|.|:..|...|..
Mouse   501 CQVESKYLAGLRRLQEAAGAEAGDFPELLQQLIQEALQWEAGEADSVGLSPVSEYDDYGFLTVPD 565

  Fly   830 RPNSDTR--------SVLSPEYLSADDLQLP-DDEDAVRPPPPPAAAAVIITKASVD------IT 879
            ....|.:        .|.|...|:.:.::.| .|..|......|:|....:.:|.|.      :.
Mouse   566 YEMEDLKLLAKIQALEVRSHHLLAHEAVERPLRDRWATLTELTPSAELKQLLRAGVPREHRPRVW 630

  Fly   880 NWERSPKAAEGDQMSPLEEQAGESGGAGVNMDALQQPKSACASPASSNGGVYSSELLEQFGLNLH 944
            .|             .:..:.......|...:.|.:.: ||..||:                  .
Mouse   631 RW-------------LVHRRVRHLQAPGCYQELLARGR-ACEHPAA------------------R 663

  Fly   945 RIEKDVQR---CDRNYWYFANENLDKLRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSY 1006
            :||.|:.|   .::::....:...||||.|:..:.|::..:||.||:..|.|..|::.:||..::
Mouse   664 QIELDLNRTFPTNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLEDEESAF 728

  Fly  1007 SCFCKLMERMIENFPSGGAMDMHFANMRSLIQILDSEMYDLMDSNGDY--THFYFCYRWFLLDFK 1069
            .|...::|.::........:.....:.|.|..:|..::..|....|.:  ......:.|||:.|.
Mouse   729 WCLVAIVETILPAEYYSKTLTASQVDQRVLQDLLSEKLPRLTAHLGQHRVDLSLITFNWFLVVFA 793

  Fly  1070 RELVYDDVFATWEVIWAAKHIASGHFVLF-LALALLETYRDII--LSNSMDFTDVIKFFNE 1127
            ..|:.|.:...|:..     :..|..|:| .|||:.:...:.|  |.:|::....::||.:
Mouse   794 DSLISDILLRVWDAF-----LYEGTKVVFRYALAIFKYNEEAILQLQDSLEIYQYLRFFTK 849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_001285494.1	RUN	45..218	CDD:280855
		PH_RUTBC	292..466	CDD:275431	28/182 (15%)
		TBC	923..1087	CDD:214540	35/168 (21%)
Tbc1d2	XP_006538109.1	PH_TBC1D2A	45..146	CDD:269966	19/118 (16%)
		PRK14951	<192..404	CDD:237865	55/286 (19%)
		COG4913	<300..>565	CDD:227250	62/301 (21%)
		TBC	620..832	CDD:214540	47/248 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900