DRSC/TRiP Functional Genomics Resources

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Protein Alignment tbc and TBC1D10C

DIOPT Version :10

Sequence 1:NP_608395.6 Gene:tbc / 318059 FlyBaseID:FBgn0052506 Length:1155 Species:Drosophila melanogaster
Sequence 2:NP_001356427.1 Gene:TBC1D10C / 374403 HGNCID:24702 Length:454 Species:Homo sapiens


Alignment Length:369 Identity:79/369 - (21%)
Similarity:115/369 - (31%) Gaps:117/369 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   801 LEEQINQEPSC---SASTASSYETVGPGEVHQRPNSDTRSVLSPEYLSADDLQLPDDEDAVRPPP 862
            |.|.:.|.|..   |:|..|..|..|||                .|..||.........| .|.|
Human     5 LGEDLVQPPELQDDSSSLGSDSELSGPG----------------PYRQADRYGFIGGSSA-EPGP 52

  Fly   863 --PPAAAAVIITKASVDIT-NWERSPKAAEGDQMSPLEEQAGESGGAGVNMDALQQ---PKSACA 921
              |||..........|::| :||::        ||...::.......|: ..||:.   |....|
Human    53 GHPPADLIRQREMKWVEMTSHWEKT--------MSRRYKKVKMQCRKGI-PSALRARCWPLLCGA 108

  Fly   922 SPASSNG-GVYSS--------ELLEQFGLNLHRIEKDVQRCDRNYWYFANENL---------DKL 968
            .....|. |.|..        :.:|..|.:|||             .|....:         ..|
Human   109 HVCQKNSPGTYQELAEAPGDPQWMETIGRDLHR-------------QFPLHEMFVSPQGHGQQGL 160

  Fly   969 RNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESL-------SYSCFCKLMERMIENFPSGGAM 1026
            ..|:..|.....:.||.|....:.|.||:....|:.       ::.|..::.|..:.     |..
Human   161 LQVLKAYTLYRPEQGYCQAQGPVAAVLLMHLPPEACALPLPQEAFWCLVQICEVYLP-----GYY 220

  Fly  1027 DMHFANMRSLIQILDSEMY-DLMDSNGDYTH----------FYFCYRWFLLDFKRELVYDDVFAT 1080
            ..|...:|     ||:|:: .|:.....:.|          ..:...|||..|.|.|.:..|...
Human   221 GPHMEAVR-----LDAEVFMALLRRLLPHVHKHLQQVGVGPLLYLPEWFLCLFARSLPFPTVLRV 280

  Fly  1081 WEVIWAAKHIASGHFVLF--------LAL----------ALLET 1106
            |:..     ::.|..|||        |||          .||||
Human   281 WDAF-----LSEGARVLFRVGLTLVRLALGTAEQRGACPGLLET 319

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tbcNP_608395.6 RUN_SGSM1_like 21..214 CDD:439049
PH_RUTBC 292..466 CDD:275431
TBC 923..1087 CDD:214540 37/199 (19%)
TBC1D10CNP_001356427.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..58 19/69 (28%)
TBC 89..302 CDD:214540 46/241 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 392..454
Interaction with calcineurin 414..454
Blue background indicates that the domain is not in the aligned region.

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