DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tbc and Tbc1d10a

DIOPT Version :9

Sequence 1:	NP_001285494.1	Gene:	tbc / 318059	FlyBaseID:	FBgn0052506	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_001015022.1	Gene:	Tbc1d10a / 360968	RGDID:	1311641	Length:	505	Species:	Rattus norvegicus

Alignment Length:	324	Identity:	58/324 - (17%)
Similarity:	107/324 - (33%)	Gaps:	99/324 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   860 PPPPPAAAAVIITKASVDITNWERSPKAAEGDQMSPLEEQA-----------------GESGGAG 907
            |..|.:..::..|:.|:     .:.|.||..|::|.|...:                 |..|..|
  Rat    10 PRAPASGGSLSGTRESL-----AQGPDAATADELSSLGSDSEANGFAERRIDKFGFIVGSQGAEG 69

  Fly   908 ----VNMDALQQPKS----------------------ACAS--PASSNGGVY------------S 932
                |.::.|:|.:|                      .|..  |.|..|..:            :
  Rat    70 ALEEVPLEVLRQRESKWLDMLNNWDKWMAKKHKKIRLRCQKGIPPSLRGRAWQYLSGGKVKLQQN 134

  Fly   933 SELLEQFGLN------LHRIEKDVQRCDRNYWYFAN---ENLDKLRNVISTYVWEHLDVGYMQGM 988
            ....::..::      |..||:|:.|....:..|.:   .....|..|:..|.....:.||.|..
  Rat   135 PGKFDELDMSPGDPKWLDVIERDLHRQFPFHEMFVSRGGHGQQDLFRVLKAYTLYRPEEGYCQAQ 199

  Fly   989 CDLVAPLLVIFDDESLSYSCFCKLMERMIENFPSGGAMDMHFANMRSLIQILDSE-MYDLMDSNG 1052
            ..:.|.||:....|. ::.|..::.|:.:..:         ::.....|| ||.| ::.|:....
  Rat   200 APIAAVLLMHMPAEQ-AFWCLVQVCEKYLPGY---------YSEKLEAIQ-LDGEILFSLLQKVS 253

  Fly  1053 DYTH----------FYFCYRWFLLDFKRELVYDDVFATWEVIWAAKHIASGHFVLF-LALALLE 1105
            ...|          ..:...||:..|.|.|.:..|...|::.:     ..|..::| :.|.||:
  Rat   254 PVAHKHLSRQKIDPLLYMTEWFMCAFARTLPWSSVLRVWDMFF-----CEGVKIIFRVGLVLLK 312

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_001285494.1	RUN	45..218	CDD:280855
		PH_RUTBC	292..466	CDD:275431
		TBC	923..1087	CDD:214540	35/195 (18%)
Tbc1d10a	NP_001015022.1	TBC	110..313	CDD:214540	40/219 (18%)
Tbc1d10a	NP_001015022.1	VCX_VCY	404..>501	CDD:291884
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900