Protein Alignment tbc and TBC1D16

DIOPT Version :10

• Sequence 1: NP_608395.6
• Gene: tbc / 318059
• FlyBaseID: FBgn0052506
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: NP_609403.2
• Gene: TBC1D16 / 34431
• FlyBaseID: FBgn0032249
• Length: 702
• Species: Drosophila melanogaster
• Alignment Length: 969
• Identity: 178/969 - (18%)
• Similarity: 292/969 - (30%)
• Gaps: 453/969 - (46%)

  Fly   294 LLYGKNNVQVLPKDVAEP------MPGYLS------LHQHIQ----TLTIKWTPNQLMNGYTEAE 342
            :|:.||||.:.|..:|..      .||||:      :.|:..    ||.:.|.||..:..||
  Fly    33 ILFCKNNVCIHPPTIARDESDILHNPGYLTCTTKTFVDQYNSAKRPTLLLTWIPNSSLCKYT--- 94

  Fly   343 EAEDIDKDAFWAYALNINVDEIVYVHCH-----QSRGEDS--GGTVILVGQDGVQRPPIHFPE-- 398
                           |:|.|:     |.     :|:..||  |...:.:.|. :|...|...:
  Fly    95 ---------------NLNADD-----CRGQCNPRSKSPDSRNGYCHVTIPQT-IQERDIREEDEN 138

  Fly   399 GGHMQQFLSCLETGLLPHGQLDPPLWSQRGIGKMFLWPRSMRRRILPSVMESVDE-------TPI 456
            ...||:.          ..:|.|.|..|..                     |:|:       .||
  Fly   139 AADMQEL----------KNELQPLLGGQAA---------------------SIDDLTALLKNNPI 172

  Fly   457 DYVFRIVSKSRHEEFAATHSILDFVRSTPRRAQLSSCST-----TGSSDCSNKS-----LSIDQF 511
            ..|...:|..:.|....:.|.              :|.|     ...|||:|.|     .:.|..
  Fly   173 TSVNITISNPQIENSNISQSF--------------NCITIRPDSNNCSDCTNGSGVGDGPATDNP 223

  Fly   512 PMESPLIL-------------QQQQQQQQQLLQAQSTSIEMV-------------CSTMRRQIIS 550
            ...:|.:|             .....:|:..::.:..|:::.             |::.:..|.|
  Fly   224 KWTTPELLAFKHNLEFPDSGNSTPADRQKSAMKCRHFSVDLSQMRSLRLFFNDDNCTSGQLVIAS 288

  Fly   551 RA--------FYGWLAYCRHLSTVRTHLSGLVHGRIT-------------------PEMKADE-- 586
            |.        .||.|   .||:.|.......:| .||                   ||:|..|
  Fly   289 RESQYKILHFHYGGL---DHLAQVLHQWHCFLH-NITSETGQDKFDLPYRHFMVCRPEVKKSEMH 349

  Fly   587 --EGLTKE------RWQLLNVNGVLENATEFYRLVYFGGVQPELRQEVWPYLLGHYAFGSTTEDR 643
              ||..|:      ...|||..|.:|:.....:.|:|||::..||:.|||:||..|:|.||.|||
  Fly   350 PDEGDVKKITTNFFYGTLLNEKGQIEDDLLLRKCVFFGGLEKSLRKTVWPFLLKCYSFSSTFEDR 414

  Fly   644 KKQDETCKHYYETTMSEWLAVDAIVQQREKEKTARAVAKLSSGSNSGNDRTVRAADLEAGGDLEN 708
                                                                             
  Fly   415 ----------------------------------------------------------------- 414

  Fly   709 EVFEDISDISDPGDLEFDEQQQQQQQQAECAVSGNHLTVKPIPRAMKTSTDSGHVDESFNELDEP 773
            .|..||
  Fly   415 AVLMDI----------------------------------------------------------- 420

  Fly   774 DEEDNKQKQQQDEKISESESKLPDYRKLEEQINQEPSCSASTASSYETVGPGEVHQRPNSDTRSV 838
                   |:|:.|:|:.        ::|..
  Fly   421 -------KRQEYEEITR--------KRLYS----------------------------------- 435

  Fly   839 LSPEYLSADDLQLPDDEDAVRPPPPPAAAAVIITKASVDITNWERSPKAAEGDQMSPLEEQAGES 903
            :|||.                                 .|..|:
  Fly   436 MSPEQ---------------------------------QIHFWK--------------------- 446

  Fly   904 GGAGVNMDALQQPKSACASPASSNGGVYSSELLEQFGLNLHRIEKDVQRCDRNYWYFA---NENL 965
                                        :.:::         :||||.|.||...:|.   |.|.
  Fly   447 ----------------------------TVQIV---------VEKDVVRTDRTNPFFCGDDNPNT 474

  Fly   966 DKLRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKLMERMIENF---PSGGAMD 1027
            :.::|::..:...:..:.|.|||.||:||:|....:||.::.||..||:|..  |   |:...:|
  Fly   475 EVMKNILLNFAVYNTGMSYSQGMSDLLAPVLCEVQNESETFWCFVGLMQRAF--FVCTPTDRDVD 537

  Fly  1028 MHFANMRSLIQILDSEMYDLMDSNGDYTHFYFCYRWFLLDFKRELVYDDVFATWEVIWAAKHIAS 1092
            .:.:.:|.||:|:....|..::.:.|.....||:||.||.||||.....|...||..|:  :..:
  Fly   538 HNLSYLRELIRIMLPHFYKHLEQHNDSMELLFCHRWLLLCFKREFTEAVVIRMWEACWS--NYLT 600

  Fly  1093 GHFVLFLALALLETYRDIILSNSMDFTDVIKFFNEMAERHNAQSVLQLARSLVLQLQMI 1151
            .:|.|||.||::..|.|.:::.::...:::..|:.:|...:.|.:|:.||.|:.|.:.:
  Fly   601 DYFHLFLCLAIIAVYADDVVAQNLRPDEMLLHFSSLAMYMDGQLILRKARGLLHQYRQL 659

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_608395.6	RUN_SGSM1_like	21..214	CDD:439049
		PH_RUTBC	292..466	CDD:275431	42/203 (21%)
		TBC	923..1087	CDD:214540	50/169 (30%)
TBC1D16	NP_609403.2	TBC	387..618	CDD:214540	86/499 (17%)