DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tbc and Tbc1d15-17

DIOPT Version :9

Sequence 1:	NP_001285494.1	Gene:	tbc / 318059	FlyBaseID:	FBgn0052506	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_001259806.1	Gene:	Tbc1d15-17 / 33184	FlyBaseID:	FBgn0031233	Length:	715	Species:	Drosophila melanogaster

Alignment Length:	921	Identity:	196/921 - (21%)
Similarity:	325/921 - (35%)	Gaps:	334/921 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   268 GSFKSIASASVAKDYVESLHQNAKATLLYGKNNVQVLPKDVAEPM-----PGYLSLHQHIQT--- 324
            |.|.....:||.:| |::|.|.....:|:..:.| :|.|..||.:     .|.|||.::.::
  Fly    16 GVFNESQLSSVEED-VQNLPQQGTGNILFTHDGV-LLKKASAEHIADLNTSGSLSLVEYSRSIAE 78

  Fly   325 -----LTIKWTPNQLMNGYTEAEEAEDIDKDAFWAYALNINVDEIVYVHCHQSRGEDSGGTVILV 384
                 |.::|.||   :....|::::|   ...||.     ||.|            ||.|....
  Fly    79 MPRRRLLLEWQPN---DSIMIADDSQD---QGDWAL-----VDRI------------SGRTRTTS 120

  Fly   385 GQDGVQRPPIHFPEGGHMQQFLSCLETGLLPHGQLDPPLWSQRGIGKMFLWPRSMRRRILPSVME 449
            ........||. |.||                                    .:.|.|::.:.:|
  Fly   121 ECRAFNTRPIE-PSGG------------------------------------ATTRSRVMRAQLE 148

  Fly   450 SVDETPIDY---VFRIVSKSR---HEEFAATHSILD-FVRSTPRRAQLSSCSTTGSSDCSNKSLS 507
            .:....:.:   ..|.:.|..   |.||...|...| ||||
  Fly   149 DLSSVEVRHRGQTIRFMRKGANGVHSEFFFQHGNADLFVRS------------------------ 189

  Fly   508 IDQFPMESPLILQQQQQQQQQLLQAQSTS-----IEMVCSTMRRQIISRAFYGWLAYCRHLSTVR 567
                            .:.|.|::...||     :..:.:| ..|.:.:.|
  Fly   190 ----------------MRDQHLIENAETSRSGGEVYAILTT-ENQKLKKTF-------------- 223

  Fly   568 THLSGLVHGRITPEMKADEEGLTKERWQLLNVNGVLENATEFYRLVYFGGVQPELRQ--EVWPYL 630
               :.|..|:|    ||.:  |.:|.|....:.|:|.|..::        |||..::  :..|.:
  Fly   224 ---AELDIGQI----KASQ--LPRESWLPNKLAGILGNIPDY--------VQPPFQRSPKSRPGV 271

  Fly   631 LGHYAFGSTTEDRKKQDETCKHYYETTMSEWLAVDAIVQQREKEKTARAVAKLSSGSNS-----G 690
            |       .:.||    :|....|:                        :..||..:||     |
  Fly   272 L-------ISGDR----QTSPDNYQ------------------------IIGLSGSTNSACSSNG 301

  Fly   691 NDRTVRAADLEAGGDLENEVFEDISDISDPGDLEFDEQQQQQQQQAECAVSGNHLTVKPIPRAMK 755
            ..|         ||..|          ..|.|.|.:....|.::..      |:|
  Fly   302 QSR---------GGSAE----------KSPADSELETLNAQDEKIV------NNL---------- 331

  Fly   756 TSTDSGHVDESFNELDEPDEEDNKQKQQQDEKISES---ESKLPDYRKLEEQINQEPSCSASTAS 817
                             ||    :|:.::...::|:   |.:.||.|            .:.:|.
  Fly   332 -----------------PD----RQRVERGHPLTETQWLEFQTPDGR------------ISDSAR 363

  Fly   818 SYETVGPGEVHQRPNSDTRSVLSPEYLSADDLQLPDDEDAVRPPPPPAAAAVIITKASVDITNWE 882
            ..|.:..|.|.|....:....|...||.:|                               |:.|
  Fly   364 IKELIFRGGVVQSLRPEVWKFLLNYYLWSD-------------------------------THVE 397

  Fly   883 RSPKAAEGDQMSPLEEQAGESGGAGVNMDALQQPKSACASPASSNGGVYSSELLEQFGLNLHRIE 947
            |            :|.:..:|    :....::....|..:...:|...|.....:        ||
  Fly   398 R------------IERRKQKS----IEYYNMKAQWLAMTTTQEANFCGYRERKCQ--------IE 438

  Fly   948 KDVQRCDRNYWYFA---NENLDKLRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCF 1009
            |||:|.||:..:||   |.||..|:.::.|||..:.|:||:|||.||:||:|.|..:|..::.||
  Fly   439 KDVKRTDRSLQFFAGEDNPNLTLLQGILMTYVMYNFDLGYVQGMSDLLAPILEIQVNEVDTFWCF 503

  Fly  1010 CKLMERMIENFPSGGA-MDMHFANMRSLIQILDSEMYDLMDSNGDYTHFYFCYRWFLLDFKRELV 1073
            ...||.:..||....| |...||.:|.||:..::.:::.|.|: |..:.|||:||.|:.:||||.
  Fly   504 VGFMELVFTNFDIDQAGMKTQFAQIRRLIEFANAPLFNYMRSH-DSDNMYFCFRWLLVWYKRELN 567

  Fly  1074 YDDVFATWEVIWAAKHIASGHFVLFLALALLETYRDIILSNSMDFTDVIKFFNEMAERHNAQSVL 1138
            .:||...||.:|.  .:...:|.|..::|:|:....:|:.:..:||:::|..||::...:.|..|
  Fly   568 SEDVLKLWECLWT--RLPCPNFHLLFSVAILDQETRVIIDSQYEFTEILKHVNELSGNIDVQKTL 630

  Fly  1139 QLARSLVLQLQ 1149
            |:|..:.|||:
  Fly   631 QVAEGIYLQLK 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_001285494.1	RUN	45..218	CDD:280855
		PH_RUTBC	292..466	CDD:275431	33/189 (17%)
		TBC	923..1087	CDD:214540	63/167 (38%)
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931	43/254 (17%)
Tbc1d15-17	NP_001259806.1	TBC	369..598	CDD:214540	80/286 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456562
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22957
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840