DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tbc and CG1695

DIOPT Version :9

Sequence 1:	NP_001285494.1	Gene:	tbc / 318059	FlyBaseID:	FBgn0052506	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_728346.2	Gene:	CG1695 / 33046	FlyBaseID:	FBgn0031116	Length:	1192	Species:	Drosophila melanogaster

Alignment Length:	1255	Identity:	816/1255 - (65%)
Similarity:	931/1255 - (74%)	Gaps:	183/1255 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 NADG------SDYKERLIASVKKEVKQLMEEAVTKKYVHEESSSVTSLCGAVEACLSQGLRRRAL 63
            ||.|      ::.||||||||||||||||||||||||||||||||||||||||||||.|||||||
  Fly    17 NASGDVSNAETELKERLIASVKKEVKQLMEEAVTKKYVHEESSSVTSLCGAVEACLSHGLRRRAL 81

  Fly    64 GLFKTSSTTALLHKIAKSCPEAEHISKLVQEIEASDPS-----KRSSSSSDSFQRPPMLKKSSSN 123
            |||||||||||:.||||.||||:::|:.:.|:|.:..|     ||||.||||..:|.:|.|.|.:
  Fly    82 GLFKTSSTTALIQKIAKICPEADYVSRRLLELELAQESHAVSGKRSSCSSDSIIKPKLLSKGSGS 146

  Fly   124 S-----MSTGTNAAASTSSASASISVSASTSSMSLASMKYLWIRLALYEKRLTKIIEYLVSNASS 183
            |     ::|.||.|.:........|....         |||||||||:||||.||||:|||||:|
  Fly   147 SNSVTTINTVTNGAGAGPGGGGGASAPLG---------KYLWIRLALHEKRLAKIIEHLVSNANS 202

  Fly   184 FYDRDSLVADSDYGSILSSLLVGPCALEFTRAKTADHYWTDPHADELVQRHRISSCRRSSSTCSR 248
            :|||::||||.||||||||||||||||||||||||||||:||.||||||||||||..|:..|..|
  Fly   203 YYDREALVADPDYGSILSSLLVGPCALEFTRAKTADHYWSDPCADELVQRHRISSGNRTPPTTHR 267

  Fly   249 PAIINFKRSLNTSSDEAGTGSFKSIASASVAKDYVESLHQNAKATLLYGKNNVQVLPKDVAEPMP 313
            | ||||||||:|||::..:||||:.:.||||||||||||||::.|||||||||.||||||:||||
  Fly   268 P-IINFKRSLHTSSEDTSSGSFKACSPASVAKDYVESLHQNSRTTLLYGKNNVLVLPKDVSEPMP 331

  Fly   314 GYLSLHQHIQTLTIKWTPNQLMNGYTEAEEAEDIDKDAFWAYALNINVDEIVYVHCHQSRGEDSG 378
            |||||||.||:||||||||||||||.:.:..   ||..:|:|||||||||||||||||:||.|:|
  Fly   332 GYLSLHQSIQSLTIKWTPNQLMNGYNDGDGG---DKSFYWSYALNINVDEIVYVHCHQNRGGDTG 393

  Fly   379 GTVILVGQDGVQRPPIHFPEGGHMQQFLSCLETGLLPHGQLDPPLWSQRGIGKMFLWPRSMRRRI 443
            ||:||||||||||||||||||||:|.|||||||||||||||||||||||||||:|.||:|:||.|
  Fly   394 GTIILVGQDGVQRPPIHFPEGGHLQAFLSCLETGLLPHGQLDPPLWSQRGIGKLFPWPKSVRRHI 458

  Fly   444 LPSVMES----VDETPIDYVFRIVSKSRHEEFAATHSILDFVRSTPRRAQLSSCSTTGSSDCSNK 504
            ||||||:    .||||||||||:|||.:||||.|:|.||:..||:|||..|.|||||||||||:|
  Fly   459 LPSVMEAGGSVTDETPIDYVFRVVSKCQHEEFLASHPILELGRSSPRRKHLGSCSTTGSSDCSSK 523

  Fly   505 SLSIDQFPMESPLILQQQQQQQQQLLQA-QSTSIEMVCSTMRRQIISRAFYGWLAYCRHLSTVRT 568
            ||||||...|:|||            || ||||||:|||||||||||||||||||||||||||||
  Fly   524 SLSIDQSSCETPLI------------QASQSTSIELVCSTMRRQIISRAFYGWLAYCRHLSTVRT 576

  Fly   569 HLSGLVHGRITPEMKADEEGLTKERWQLLNVNGVLENATEFYRLVYFGGVQPELRQEVWPYLLGH 633
            ||||||:|||.|::.|||||||:.:|..::.:||:....|.|||||||||:||||:|||||||||
  Fly   577 HLSGLVNGRIMPDLAADEEGLTRGKWLAMHEDGVVTGDLELYRLVYFGGVEPELRKEVWPYLLGH 641

  Fly   634 YAFGSTTEDRKKQDETCKHYYETTMSEWLAVDAIVQQREKEKTARAVAKLS--------SGSNSG 690
            |.||||.|:||||||||||||||||||||||:|||:||||||||.||||||        :.::|.
  Fly   642 YDFGSTPEERKKQDETCKHYYETTMSEWLAVEAIVRQREKEKTALAVAKLSAEQARLAANATSSS 706

  Fly   691 NDRTVRA-----ADLEAGG-----------DLENEVFE--DISDISDPGDLEFDE----QQQQQQ 733
            |.....|     ..||.|.           :.||:||:  |.||||||||| |||    |:.::|
  Fly   707 NPHQKLANGSQQLQLEHGNGEEDQENLVLDEGENDVFDDNDFSDISDPGDL-FDEPELGQEAEEQ 770

  Fly   734 QQAECAVSGNHLTVKPIPRAMKTSTDSGHVDESF-NELDEPDEEDNKQKQQQDEKISESESKLPD 797
            :|                        |...:|.| .:.||.|:||:.|:    |....||..:.:
  Fly   771 EQ------------------------SNLEEEVFEKQEDEEDQEDHDQR----EMPRLSEKLVLE 807

  Fly   798 YRKLEEQINQEP-----SC--------------------------SASTASSYETVG-------- 823
            ::.::   |.||     :|                          |:.:.|||||||
  Fly   808 FQNID---NMEPLRLQENCFADSETENDLGLGLDSSGNILMLSIKSSPSTSSYETVGNEFLDMAE 869

  Fly   824 --------PGEVHQRPNSDTRSVLSPEYLSADDLQL--PDDEDAVRPPPPPAAAAVIITK-ASVD 877
                    ||::             .::.||||::|  .|:|::.:|     |.|||||: ||:|
  Fly   870 AKLEEEEPPGQL-------------SKFHSADDVRLDNQDEEESSQP-----ATAVIITEAASLD 916

  Fly   878 ITNWERSPK--AAEGDQMSPLEEQAGESGGAGVNMDALQQPKSACASPASSNGGVYSSELLEQFG 940
            ..:.:.:.:  :.:...||||.|..    ....::||||:|||||.|||||||||||.|||||||
  Fly   917 ALDDDPTEEFTSRKTSLMSPLNEDI----TVVASLDALQEPKSACVSPASSNGGVYSVELLEQFG 977

  Fly   941 LNLHRIEKDVQRCDRNYWYFANENLDKLRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESLS 1005
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Fly   978 LNLHRIEKDVQRCDRNYWYFANENLDKLRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESLS 1042

  Fly  1006 YSCFCKLMERMIENFPSGGAMDMHFANMRSLIQILDSEMYDLMDSNGDYTHFYFCYRWFLLDFKR 1070
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Fly  1043 YSCFCKLMERMIENFPSGGAMDMHFANMRSLIQILDSEMYDLMDSNGDYTHFYFCYRWFLLDFKR 1107

  Fly  1071 ELVYDDVFATWEVIWAAKHIASGHFVLFLALALLETYRDIILSNSMDFTDVIKFFNEMAERHNAQ 1135
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Fly  1108 ELVYDDVFATWEVIWAAKHIASGHFVLFLALALLETYRDIILSNSMDFTDVIKFFNEMAERHNAQ 1172

  Fly  1136 SVLQLARSLVLQLQMIIENK 1155
            |:|||:||||||||.|||||
  Fly  1173 SILQLSRSLVLQLQTIIENK 1192

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_001285494.1	RUN	45..218	CDD:280855	111/182 (61%)
		PH_RUTBC	292..466	CDD:275431	141/177 (80%)
		TBC	923..1087	CDD:214540	162/163 (99%)
CG1695	NP_728346.2	RUN	63..237	CDD:280855	111/182 (61%)
		PH_RUTBC	310..485	CDD:275431	141/177 (80%)
		SRP68-RBD	<648..>713	CDD:304552	42/64 (66%)
		TBC	947..1124	CDD:214540	172/176 (98%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45473138
Domainoid	1	1.000	294	1.000	Domainoid score	I1468
eggNOG	1	0.900	-	-		E1_COG5210
Homologene	1	1.000	-	-		H64485
Inparanoid	1	1.050	237	1.000	Inparanoid score	I1101
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48923
OrthoDB	1	1.010	-	-		D171826at2759
OrthoFinder	1	1.000	-	-		FOG0002045
OrthoInspector	1	1.000	-	-		mtm6445
orthoMCL	1	0.900	-	-		OOG6_103962
Panther	1	1.100	-	-	P	PTHR22957
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3416
SonicParanoid	1	1.000	-	-		X1347
	14	13.840