DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tbc and Evi5

DIOPT Version :9

Sequence 1:	NP_001285494.1	Gene:	tbc / 318059	FlyBaseID:	FBgn0052506	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_727526.2	Gene:	Evi5 / 32088	FlyBaseID:	FBgn0262740	Length:	807	Species:	Drosophila melanogaster

Alignment Length:	438	Identity:	98/438 - (22%)
Similarity:	158/438 - (36%)	Gaps:	133/438 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   756 TSTDSGHVDESFNELDE-----PDEE-------DNKQKQQQDEKISESESKLPDYRKLEEQINQE 808
            |:|.:....||..::|.     |.||       |...|.:...|:.||::|
  Fly     4 TTTTTASSAESQAKMDVKGGALPGEENLPTSEMDLLAKLEAANKLIESDAK-------------- 54

  Fly   809 PSCSASTASSYETVGPGEVHQRPNSDTRSV---LSPEYLSADDLQ------LPDDEDAVRPPPP- 863
                 |..|.:.|      |.|.||||..:   .|...::.:|:.      |.|.|.|::...|
  Fly    55 -----SLNSLHST------HSRKNSDTSQISLTSSGNSVAEEDIWTTWATILNDWEGALKRKNPC 108

  Fly   864 ---------PAAAAVIITKASVDITNWERSPKAAEGDQMSPLEEQAGESGGAGVNMDALQQPKSA 919
                     |.....|:         |::...|::||:....|               ..:..||
  Fly   109 VSELVRRGIPHHFRAIV---------WQQLSGASDGDKKQYAE---------------YIKATSA 149

  Fly   920 CASPASSNGGVYSSELLEQFGLNLHRIEKDVQRCDRNYWYFANEN---LDKLRNVISTYVWEHLD 981
            |...                      |.:|:.|......:|..::   .:.|.|||..|.....:
  Fly   150 CEKV----------------------IRRDIARTYPEVEFFKEKDGPGQEALFNVIKAYSLHDRE 192

  Fly   982 VGYMQGMCDLVAPLLVIFDDESLSYSCFCKLME--RMIENF-PSGGAMDMHFANMRSLIQILDSE 1043
            |||.||...:|..||:...:|. :::...::|:  ||...| ||...:.:....:.:|:|....:
  Fly   193 VGYCQGSGFIVGLLLMQMPEEE-AFAVLVQIMQQHRMRHMFKPSMSELGLCMYQLENLVQEQIPD 256

  Fly  1044 MYDLMDSNGDYTHFYFCYRWFLLDFKRELVYD------DVFATWEVIWAAKHIASG-HFVLFLAL 1101
            |:......|..|..| ...|||..:...|..:      |||           ::.| .|:..:||
  Fly   257 MHIHFQQQGFQTTMY-ASSWFLTLYTTTLNVNLSCRIMDVF-----------LSEGMEFIFKVAL 309

  Fly  1102 ALLETYRDIILSNSMDFTDVIKFF-NEMAERHNA--QSVLQLARSLVL 1146
            |||.|.:|.:|  .:|...::||| .|:..|..|  :....||.|:.|
  Fly   310 ALLLTGKDTLL--CLDMEAMLKFFQKELPGRVEADVEGFFNLAYSIKL 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_001285494.1	RUN	45..218	CDD:280855
		PH_RUTBC	292..466	CDD:275431
		TBC	923..1087	CDD:214540	37/175 (21%)
Evi5	NP_727526.2	TBC	113..320	CDD:214540	56/265 (21%)
Evi5	NP_727526.2	DUF4527	627..>731	CDD:291689
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456623
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22957
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030