Protein Alignment tbc and Tbc1d2b

DIOPT Version :10

• Sequence 1: NP_608395.6
• Gene: tbc / 318059
• FlyBaseID: FBgn0052506
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: XP_063121637.1
• Gene: Tbc1d2b / 315880
• RGDID: 1307436
• Length: 971
• Species: Rattus norvegicus
• Alignment Length: 1064
• Identity: 194/1064 - (18%)
• Similarity: 336/1064 - (31%)
• Gaps: 397/1064 - (37%)

  Fly   266 GTGSFKSIASASVAKD------YVESL---------------HQNAKATLLYGKNNVQVLP---- 305
            |||   |.|.|...::      |::.|               ..:.:..|.|.|:....||
  Rat    21 GTG---SEAGAVAGREPSRLCGYLQKLSGKGPLRGYRSRWFVFDSRRCYLYYFKSPQDALPLGHL 82

  Fly   306 ------------KDVAEP---MPGYLSLHQHIQTLTIKWTPNQLMNGY--TEAEEAEDIDKDAFW 353
                        .:.|||   .|.:..:|. ...:|:...||:.:..|  .|.::..       |
  Rat    83 DIADACFSYQGRDEAAEPGADPPTHFQVHS-AGVVTVLKAPNRELMTYWLQELQQKR-------W 139

  Fly   354 AYALNINV---------------------DEIVYVHCHQSRGEDSGGTVI--------LVGQDGV 389
            .|..::::                     |....:..|.:...:...||:        |||....
  Rat   140 EYCNSLDMVKWDSRTSPTPGDFPKGLVARDNTDIISQHPNPSAEKARTVLAVEAAPGELVGDRAA 204

  Fly   390 QRPPIHFPE----------GGHMQQFLSCLETGLLPHGQ--------------LDPPLWSQRGIG 430
            ..|....|.          |..::..:|....| ..|.:              ||||
  Rat   205 HHPAPGHPNSINFYSLKQWGNEIKNSMSSFRPG-RGHSESRRTVFYTNEEWELLDPP-------- 260

  Fly   431 KMFLWPRSM--------RRRILPSVMESVDETPIDYVFRIVSKSRHEEFAATHSILDFVRSTPRR 487
                 |:.:        |::.:|...:.|..:...:.|      ....:.....:.|.:.|...|
  Rat   261 -----PKDLEESLAQEDRKKPVPEGSKGVTSSGFPFEF------GRNPYKGKRPLKDIIGSYKNR 314

  Fly   488 AQLSSCSTTGSSDCSNKSLSIDQFPMESPLILQQQQQQQQQL---LQAQSTSIEMVCSTMRRQII 549
            ...|.....|:|..|:..|: ...| |..|.:|.||::.:||   |.:|...::::..|:|....
  Rat   315 HSSSDPLIEGTSSGSSGGLA-KPVP-EMQLQIQSQQEELEQLKKDLSSQKELVQLLQQTVRSSQY 377

  Fly   550 SRAFYGWLAYCRHLSTVRTHLSGLVHGRITPEMKADEEGLTKERWQLLNVNGVLENATEFYRLVY 614
            .:.|   :::.......|..|. |:|       :.||        |:|.::|.||.
  Rat   378 DKYF---MSHQISQGVPRDTLE-LLH-------QKDE--------QILGLSGQLER--------- 414

  Fly   615 FGGVQPELRQEVWPYLLGHYAFGSTTEDRKKQDETCKHYYETTMSEWLAVDAIVQQREKEKTARA 679
                                 ||                                 .|||...:.
  Rat   415 ---------------------FG---------------------------------LEKESLQQE 425

  Fly   680 VAKLSSGSNSGNDR------TVRAADLEAGGDLENEVFEDISDISDPGDLEFDEQQQQQQQQAEC 738
            |..|.|.....|:|      |::|.|         ||...:|                     ||
  Rat   426 VRTLKSKVGELNERLGMLMETIQAKD---------EVIIKLS---------------------EC 460

  Fly   739 AVSGNHLTVKP-IPRAMKTSTDSGHVDESFNELDEPDEED---------------NKQKQQQD-- 785
            ..|.:..|:.| .|.|...|.|...:|...:.|.....::               |.:::::|
  Rat   461 EGSVSSPTMGPSSPLATPASRDQLELDRLKDSLQGYKSQNKFLNKEILELSALRRNAERRERDLM 525

  Fly   786 EKISESESKL----PDYRKLEEQINQEPSCSASTASSYETVGPG--------------EVHQRPN 832
            .|.|..|:||    ..|..|.::: :.|.||       |..||.              |..::|.
  Rat   526 AKYSSLEAKLCQVESKYLILLQEM-KTPVCS-------EEQGPARDVIAQLLEDALQVESQEQPE 582

  Fly   833 SDTRSVLSPEYLSADDL----QLPDDEDAVRPPPPPAAAAVIITKASVDITNWERSPKAAEGDQM 893
               ::.:.|..:|..|:    .:|||::..:          ::.|.           :|.:...:
  Rat   583 ---QAFVKPHLVSEFDIYGFRTVPDDDEEEK----------LVAKV-----------RALDLKTL 623

  Fly   894 SPLEEQAGESGGAGVNMDALQQPKSACASPASSN------------------------------- 927
            ...|.|...:|....|..|....:....||...|
  Rat   624 YLTENQEVSTGVKWENYFASTMNREMVCSPELKNLIRAGIPHEHRSKVWKWCVDRHTRKFKDSME 688

  Fly   928 GGVYSSEL---LEQFGLNLHRIEKDVQRC---DRNYWYFANENLDKLRNVISTYVWEHLDVGYMQ 986
            .|.:.:.|   ||:......:||.|:.|.   :::|....:|.:.|||||:..:.|.:.|:||.|
  Rat   689 PGYFQALLQKALEKQNPASKQIELDLLRTLPNNKHYSSPTSEGIQKLRNVLLAFSWRNPDIGYCQ 753

  Fly   987 GMCDLVAPLLVIFDDESLSYSCFCKLMERMIENFPSGGAMDMHFANMRSLIQILDSEMY-DLMDS 1050
            |:..|||..|:..:.|. ::.|...::|..         |...:.....|...:|..:: ||:..
  Rat   754 GLNRLVAVALLYLEQED-AFWCLVTIVEVF---------MPRDYYTKTLLGSQVDQRVFRDLLSE 808

  Fly  1051 NGDYTHFYF----------CYRWFLLDFKRELVYDDVFATWEVIWAAKHIASGHFVLF-LALALL 1104
            .....|.:|          .:.|||:.|...:|.|.:|..|:     ..:..|..|:| .||||.
  Rat   809 KLPRLHTHFEQYKVDYTLITFNWFLVVFVDSVVSDILFKIWD-----SFLYEGPKVIFRFALALF 868

  Fly  1105 ETYRD---IILSNSMDFTDVIKFF 1125
            : |::   :.|.:||.....:::|
  Rat   869 K-YKEEEILKLQDSMSIFKYLRYF 891

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_608395.6	RUN_SGSM1_like	21..214	CDD:439049
		PH_RUTBC	292..466	CDD:275431	39/255 (15%)
		TBC	923..1087	CDD:214540	45/211 (21%)
Tbc1d2b	XP_063121637.1	None