Protein Alignment tbc and Tbc1d2

DIOPT Version :9

• Sequence 1: NP_001285494.1
• Gene: tbc / 318059
• FlyBaseID: FBgn0052506
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: XP_006238118.1
• Gene: Tbc1d2 / 313234
• RGDID: 1306860
• Length: 924
• Species: Rattus norvegicus
• Alignment Length: 643
• Identity: 124/643 - (19%)
• Similarity: 226/643 - (35%)
• Gaps: 156/643 - (24%)

  Fly   561 RHLSTVRTHLSGLVHGRITPEMKADEEG----LTKERWQLLNVNGVLENATEFYRLVYFGGVQPE 621
            |..:|......||...|...|.....|.    ||||......:..:|..|.|        ..|.|
  Rat   288 RQSNTFPFFSDGLARSRTAQEKVVALEQQVLMLTKELKSQKELVIILHKALE--------AAQQE 344

  Fly   622 LRQEVWPYLLGHYAFGSTTEDRKKQDETCKHYYETTMSEWLAVDAIVQQRE--------KEKTAR 678
            .|        ...|:.:.||||.:. |..:|...........|:|:.|.||        :|:..:
  Rat   345 KR--------ASSAYLAATEDRDRL-ELVRHKVRQIAELNQRVEALEQDRERLVHEAGLREQQVQ 400

  Fly   679 AV---AKLSSGSNSGNDRTVRAADLEAGGDLENEVFEDISDISDPGDLEFDEQQQQQQQQAECAV 740
            |:   .:|....|....:.:        ..|..::.||::                |.|.|: |.
  Rat   401 ALQQHVQLLMDKNQAKQQVI--------CKLSQKLTEDLA----------------QPQPAD-AT 440

  Fly   741 SGNHLTVKPIPRAMKTSTDSGHVDESF--NELDEPDEEDNKQKQQQDEKIS----------ESES 793
            :|:.|:.:.....:|...::......|  :|:.:..:...|..:::...::          :.||
  Rat   441 NGDFLSQQERLEHLKDDMEAYRTQNRFLNSEIHQVTKIWRKVAEKEKALLTKCAYLQARNCQVES 505

  Fly   794 K-LPDYRKLEEQINQEP------------------------SCSASTASSYETVGPGEVHQRPNS 833
            | |...|:|:|....||                        |...|..|.|:..|...|......
  Rat   506 KYLAGLRRLQEAAGAEPGDFPELLQQLVQEALQWEAGEASDSVGLSPVSEYDDYGFLTVPDYEVE 570

  Fly   834 DTR--------SVLSPEYLSADDLQLP-DDEDAVRPPPPPAAAAVIITKASVD------ITNWER 883
            |.:        .|.|...|:.:.::.| .|..|......|:|....:.:|.|.      :..|
  Rat   571 DLKLLAKIQALEVRSHHLLALEAVERPLRDRWATLTELMPSAELKQLLRAGVPREHRPRVWRW-- 633

  Fly   884 SPKAAEGDQMSPLEEQAGESGGAGVNMDALQQPKSACASPASSNGGVYSSELLEQFGLNLHRIEK 948
                       .:..:......:|...:.|.:.: ||..||:                  .:||.
  Rat   634 -----------LVHRRVQHLHSSGCYQELLARGR-ACEHPAA------------------RQIEL 668

  Fly   949 DVQR---CDRNYWYFANENLDKLRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFC 1010
            |:.|   .::::....:...||||.|:..:.|::..:||.||:..|.|..|::.:||..::.|..
  Rat   669 DLNRTFPTNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLEDEESAFWCLV 733

  Fly  1011 KLMERMIENFPSGGAMDMHFANMRSLIQILDSEMYDLMDSNGDYTHF---YFCYRWFLLDFKREL 1072
            .::|.::........:.....:.| ::|.|.||....:.::....|.   ...:.|||:.|...|
  Rat   734 AIVETILPAEYYSKTLTASQVDQR-VLQDLLSEKLPRLTAHLGQRHVDLSLITFNWFLVIFADSL 797

  Fly  1073 VYDDVFATWEVIWAAKHIASGHFVLF-LALALLETYRDII--LSNSMDFTDVIKFFNE 1127
            :.|.:...|:..     :..|..|:| .|||:.:...:.|  |.:|::....::||.:
  Rat   798 ISDILLRVWDAF-----LYEGTKVVFRYALAIFKYNEEAILRLQDSLEIYQYLRFFTK 850

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_001285494.1	RUN	45..218	CDD:280855
		PH_RUTBC	292..466	CDD:275431
		TBC	923..1087	CDD:214540	36/169 (21%)
Tbc1d2	XP_006238118.1	PH_TBC1D2A	44..145	CDD:269966
		PH	44..137	CDD:278594
		TBC	621..833	CDD:214540	48/249 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900