Protein Alignment tbc and Rabgap1l

DIOPT Version :9

• Sequence 1: NP_001285494.1
• Gene: tbc / 318059
• FlyBaseID: FBgn0052506
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: XP_006250167.1
• Gene: Rabgap1l / 304914
• RGDID: 1304620
• Length: 1051
• Species: Rattus norvegicus
• Alignment Length: 862
• Identity: 167/862 - (19%)
• Similarity: 280/862 - (32%)
• Gaps: 307/862 - (35%)

  Fly   391 RP--PIHFPEGG----HMQQFLSCLETGLLPHGQLDPPLWSQRGIGKMFLWPRSMRRR------- 442
            ||  |..|||..    :...:|.|::..            |.|..|:......:||..
  Rat   116 RPSSPSGFPEEDSVLFNKLTYLGCMKVS------------SPRSEGEALRAMATMRASSQYPFAV 168

  Fly   443 --ILPSVME-SVDETPIDYVFRIVSKSRHEEFAA--THSILDFVRSTPRRAQLSSCSTTGSSDCS 502
              .:|:|.| ||         ||:.:|.:.|.|:  .:.:|...|......: |:|.....|...
  Rat   169 TLYVPNVPEGSV---------RIIDQSSNVEIASFPIYKVLFCARGHDGTTE-SNCFAFTESSHG 223

  Fly   503 NKSLSIDQFPMESPLILQQQQQQQQQLLQAQSTSIEMVCSTMRRQIISRAFYGWLAYCRHLSTVR 567
            ::...|..|..|              :.:|.|..:...|:..:|.            .|.:|.|:
  Rat   224 SEEFQIHVFSCE--------------IKEAVSRILYSFCTAFKRS------------SRQVSDVK 262

  Fly   568 THLSGLVHGRITPEMKADEEGLTKERWQLLNVNGVLENATEFYRLVYFGGVQPELRQEVWPYLLG 632
                    ..|.|...:|                           |:...|..|::::.     |
  Rat   263 --------DSIIPTPDSD---------------------------VFTFSVSLEVKEDD-----G 287

  Fly   633 HYAFGSTTEDRKKQDETCKHYYETTMSEWLAVDAIVQQREKEKTA--RAVAKLSSGSNSGNDRTV 695
            ...|....:||.      |.|::........|...|||...::.|  |....|.|...:..:..:
  Rat   288 KGNFSPVPKDRD------KFYFKIKQGIEKKVVITVQQLSNKELAIERCFGMLLSPGRNVKNSDM 346

  Fly   696 RAADLEAGG---DLENEVFEDISDISDPGDLEFDEQQQQQQQQAECAVSGNHLT--VKPIP---- 751
            ...|:|:.|   |....|...:.:.:.|..|..:|:..:.::..........:|  |:|:.
  Rat   347 HLLDMESMGKSYDGRAYVITGMWNPNAPIFLALNEETPKDKRVYMTVAVDMVVTEVVEPVRFLLE 411

  Fly   752 -------------------------RAMKTSTDSGH--VDESFNELDEPDEEDNKQK-------- 781
                                     ..:|.|...||  ..::..|:.....|.:|::
  Rat   412 TVVRVYPANERFWYFSRKTFTETFFMRLKQSEGKGHSSAGDAIYEVVSLQRESDKEEPVTPTSGG 476

  Fly   782 ----QQQDEKISESESKLP----DYRKLEEQINQEPSCSASTASSY-ETVG--PGEVHQRPNSDT 835
                .|:||...||:::|.    |..|         .|......|: |.:|  ...::.||....
  Rat   477 GPASPQEDEAEEESDNELSSGTGDVSK---------DCPEKILYSWGELLGRWHNNLNARPKGLP 532

  Fly   836 RSVLS--PEYLSADDLQL----PDDE---DAVRPPPPPAAAAVIITKASVDITNWERSPKAAEGD 891
            ..|.|  ||.|.|:..||    .|::   |..|         ::|||.|.     :.|....:..
  Rat   533 TLVKSGVPEALRAEVWQLLAGCHDNQAMLDKYR---------ILITKDSA-----QESVITRDIH 583

  Fly   892 QMSPLEEQAGESGGAGVNMDALQQPKSACASPASSNGGVYSSELLEQFGLNLHRIEKDVQRCDRN 956
            :..|..:...::||.|
  Rat   584 RTFPAHDYFKDTGGDG------------------------------------------------- 599

  Fly   957 YWYFANENLDKLRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKLMERMIE--- 1018
                 .|:|.|:....|.|   ..|:||.||...|.|.||:...:|    ..||.|:..|.:
  Rat   600 -----QESLYKICKAYSVY---DEDIGYCQGQSFLAAVLLLHMPEE----QAFCVLVNIMYKYKL 652

  Fly  1019 ------NFPSGGAMDMH--FANMRSLIQILDSEMYDLMDSNGDYTHF--------YFCYRWFLLD 1067
                  ||.     |:|  |..:..|:|   .::.||      |:||        .:..:|||..
  Rat   653 RDLYKNNFE-----DLHCKFYQLEKLMQ---EQLPDL------YSHFCDLNLEAHMYASQWFLTL 703

  Fly  1068 FKRELVYDDVFATWEVIWAAKHIASGHFVLF-LALALLETYRDIILSNSMDFTDVIKFFN-EMAE 1130
            |..:.....||...:::     :..|..::| :|||||:|.::.:|  ..||...:|||. ::.:
  Rat   704 FTAKFPLCMVFHIIDLL-----LCEGLNIIFHVALALLKTSKEDLL--QADFEGALKFFRVQLPK 761

  Fly  1131 RHNAQSVLQLARSLVLQ 1147
            |:.|:   :.||.|:.|
  Rat   762 RYRAE---ENARRLMEQ 775

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_001285494.1	RUN	45..218	CDD:280855
		PH_RUTBC	292..466	CDD:275431	20/90 (22%)
		TBC	923..1087	CDD:214540	37/182 (20%)
Rabgap1l	XP_006250167.1	PTB_Rab6GAP	129..257	CDD:269922	29/175 (17%)
		DUF3694	340..421	CDD:289256	11/80 (14%)
		RabGAP-TBC	541..744	CDD:278964	62/296 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900