DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tbc and Tbc1d9

DIOPT Version :9

Sequence 1:	NP_001285494.1	Gene:	tbc / 318059	FlyBaseID:	FBgn0052506	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	XP_006255308.1	Gene:	Tbc1d9 / 304645	RGDID:	1308221	Length:	1262	Species:	Rattus norvegicus

Alignment Length:	740	Identity:	139/740 - (18%)
Similarity:	247/740 - (33%)	Gaps:	263/740 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   539 MVCSTMRRQIISRAFYGW--------LAYCRHLSTVRTHLSGLVHGRITP-----EMKADEE--- 587
            :.|...|:::...  :.|        |:...:.:.|.|.:.|.:.|.|..     ::|.||:
  Rat    78 IACGGSRKEVTEH--WEWLEQNLLQTLSIFENENDVTTFVRGKIQGIIAEYNKINDVKEDEDTEK 140

  Fly   588 ------------GLTKERWQLLNVNGVLENATEFYRLVYFGGVQPELRQEVWPYL-LGHYAFGST 639
                        |:.:|           |....:|...|:.|..|   ::.|.|| :.|..|.|.
  Rat   141 FKEAIVKFHRLFGMPEE-----------EKLVNYYSCSYWKGKVP---RQGWMYLSINHLCFSSF 191

  Fly   640 TEDR--------------------------KKQDETCKHYYETTMS--------EWLAVDAIVQQ 670
            ...|                          |....:.:|::...::        |.||..|:.|.
  Rat   192 LMGREAKLVIRWVDITQLEKNATLLLPDMIKVSTRSSEHFFSVFLNINETFKLMEQLANIAMRQL 256

  Fly   671 REKE--KTARAVAKLSSGSNSGNDRTVRAADLEAGGDLENEVFEDISDISDPGDLEFDEQQQQQQ 733
            .:.|  :..|::.||...|........|..|..|..:....:|.      .|.|.:.|
  Rat   257 LDNEGFEQDRSLPKLKKKSPKKVSALKRDLDARAKSERYRALFR------LPKDEKLD------- 308

  Fly   734 QQAECA---------------VSGNHL----------------------------TVKPIPRAMK 755
            ...:|.               ||.|::                            :|.|.|.::.
  Rat   309 GHTDCTLWTPFNKMHILGQMFVSTNYICFTSKEENLCSLIIPLREVTIVEKADSCSVLPSPLSIS 373

  Fly   756 TSTDSGHVDESFNELDEPDEEDNKQKQQQDEKISESESKLPDYRKLEEQINQEPSCSASTASSYE 820
            |......:..:..:.|...:..:...||...:|....|               .||::|
  Rat   374 TRNRMTFLFANLKDRDFLVQRISDFLQQTTSRIYSEFS---------------GSCNSS------ 417

  Fly   821 TVGPGEVHQRPNSDTRSVLSPEYLSADDLQLPDDEDAVRP-----PPPPAAAAVIITKASVDITN 880
               ..||:.||:|...|  ||:..::      .|.|..||     ...|.|...::|...
  Rat   418 ---DDEVYSRPSSLVSS--SPQRSTS------SDADGERPFNLNGNSVPTATQTLMTMYR----- 466

  Fly   881 WERSPKAAEGDQMSP------LEEQAGE----SGGAGVNMDALQQPK------------------ 917
             .|||     ::.:|      |:|||.:    ..|.|:.|...::.:
  Rat   467 -RRSP-----EEFNPKLAKEFLKEQAWKIHFAEYGQGICMYRTEKTRELVLKGIPERMRGELWLL 525

  Fly   918 -SACASPASSNGGVYSSELLE----QFGLNLHRIEKDVQRCDRNYWYFANE-NLDKLRNVISTYV 976
             |...:..:::.|.| .:|:|    ::.|....||:|:.|....:..|.|| .:..||.|::.|.
  Rat   526 LSGAINEKATHPGYY-EDLVEKSMGKYNLATEEIERDLHRSLPEHPAFQNEMGIAALRRVLTAYA 589

  Fly   977 WEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKLMERMIENFPSGGAMDMHFANMRSLIQILD 1041
            :.:.::||.|.| ::|..:|:::..|..::.....|.|||:.:          :.|.|.:..::|
  Rat   590 FRNPNIGYCQAM-NIVTSVLLLYAKEEEAFWLLVALCERMLPD----------YYNTRVVGALVD 643

  Fly  1042 SEMYDLMDSNGDYT-HFYFCYR-----------WFL------LDFKRELVYDDVFATWEVIWAAK 1088
            ..:::  :...||. ..|.|.:           |||      :.|:..:|..|.|
  Rat   644 QGVFE--ELARDYVPQLYDCMQDLGVISTISLSWFLTLFLSVMPFESAVVVVDCF---------- 696

  Fly  1089 HIASGHFVLF-LALALLETYRDIIL 1112
             ...|..|:| ||||:|:...|.:|
  Rat   697 -FYEGIKVIFQLALAVLDANVDKLL 720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_001285494.1	RUN	45..218	CDD:280855
		PH_RUTBC	292..466	CDD:275431
		TBC	923..1087	CDD:214540	41/186 (22%)
Tbc1d9	XP_006255308.1	PH-GRAM1_TCB1D9_TCB1D9B	157..255	CDD:275420	19/111 (17%)
		PH-GRAM2_TCB1D9_TCB1D9B	304..399	CDD:270161	11/101 (11%)
		TBC	510..720	CDD:214540	51/234 (22%)
		EFh	<891..921	CDD:298682
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900