Protein Alignment tbc and Sgsm2

DIOPT Version :10

• Sequence 1: NP_608395.6
• Gene: tbc / 318059
• FlyBaseID: FBgn0052506
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: NP_001427045.1
• Gene: Sgsm2 / 303304
• RGDID: 1306957
• Length: 1050
• Species: Rattus norvegicus
• Alignment Length: 1219
• Identity: 510/1219 - (41%)
• Similarity: 695/1219 - (57%)
• Gaps: 237/1219 - (19%)

  Fly     4 GNADGSDYKERLIASVKKEVKQLMEEAVTKKYVHEESSSVTSLCGAVEACLSQGLRRRALGLFKT 68
            |:|:.: .||:|:.:|||||||:||||||:|:|||:||.:.:|||||||||...|||||.|..::
  Rat     2 GSAEDA-VKEKLLWNVKKEVKQIMEEAVTRKFVHEDSSHIIALCGAVEACLLHQLRRRAAGFLRS 65

  Fly    69 SSTTALLHKIAKSCPEAEHISKLVQEIEASDPSKRSSSSSDSFQRPPMLKKSSSNSMSTGTNAAA 133
            ....||..|:.|:||.|..|...|||::.....:|.|..|..     .|:|..|:
  Rat    66 DKMAALFTKVGKTCPVAGDICHKVQELQQQAEGRRPSGGSQE-----ALRKQGSS---------- 115

  Fly   134 STSSASASISVSASTSSMSLASMKYLWIRLALYEKRLTKIIEYLVSNASSFYDRDSLVADSDYGS 198
                       |..|:::|..::|::|:|.||.||.|.::::||..|.|.:|::::|:||..:|.
  Rat   116 -----------SGKTTALSPQALKHIWVRTALMEKVLDRVVQYLAENCSKYYEKEALLADPVFGP 169

  Fly   199 ILSSLLVGPCALEFTRAKTADHYWTDPHADELVQRHRI-SSCRRSSSTCSRPAIINFKRSLNTSS 262
            ||:.|||||||||:|:.||||||||||.|||||||||| ....|..|...|||:...||.
  Rat   170 ILACLLVGPCALEYTKLKTADHYWTDPSADELVQRHRIRGPPNRQDSPAKRPALGIRKRH----- 229

  Fly   263 DEAGTGSFKSIASASVAKDYVESLHQNAKATLLYGKNNVQVLPKDVAEPMPGYLSLHQHIQTLTI 327
               .:||......|:.|::||||||||::..||||||||.|.||:..|.:||||||||..:.||:
  Rat   230 ---SSGSASEDRLAACAREYVESLHQNSRTRLLYGKNNVLVQPKEDMEAVPGYLSLHQSAENLTL 291

  Fly   328 KWTPNQLMNGYTEAEEAEDIDKDAFWAYALNINVDEIVYVHCHQSRGEDSGGTVILVGQDGVQRP 392
            ||||||||||.....|   ::|..:|.|||.:...:||.|||||.:   ||||::||.|||:|||
  Rat   292 KWTPNQLMNGTLGDSE---LEKSVYWDYALVVPFSQIVCVHCHQQK---SGGTLVLVSQDGIQRP 350

  Fly   393 PIHFPEGGHMQQFLSCLETGLLPHGQLDPPLWSQRGIGKMFLWPRSMRRRILPSVMESVDETPI- 456
            |:|||:|||:..||||||.||||.|||:||||:|:|.||:|  |: :|:|   |.:.|:|...:
  Rat   351 PLHFPQGGHLLSFLSCLENGLLPRGQLEPPLWTQQGKGKVF--PK-LRKR---SSIRSIDAEELG 409

  Fly   457 -----DYVFRIVSKS-RHEEF-----------AAT-----------HSILDFVRS---------- 483
                 ||||||:... |||..           ||:           |::|..:.|
  Rat   410 VGRATDYVFRIIYPGHRHEHITINYHHLAASRAASVDDDEEEEDKLHAMLSMICSRNLTAPNPMK 474

  Fly   484 --------------------TPRRAQLSSCSTTGSSDC-----SNKSLSIDQFPMESPLILQQQQ 523
                                .|..:|.|||.:..||..     |:.|.:.|:.|
  Rat   475 DAGDMIEMQGFGPSLTAWHLEPLCSQGSSCLSCPSSSSPYAPPSHCSCTPDRLP----------- 528

  Fly   524 QQQQQLLQAQSTSIEMVCSTMRRQIISRAFYGWLAYCRHLSTVRTHLSGLVHGRITPEMK--ADE 586
                         :.::|.:|:|||:||||||||||||||||||||||.|||..|.|..:  ...
  Rat   529 -------------LRLLCESMKRQIVSRAFYGWLAYCRHLSTVRTHLSALVHHNIIPPDRPPGAS 580

  Fly   587 EGLTKERWQLLNVNGVLENATEFYRLVYFGGVQPELRQEVWPYLLGHYAFGSTTEDRKKQDETCK 651
            .||||:.|.....:.......|..|.||:|||:.|:|::|||:|||||.||.:.::.::.|....
  Rat   581 GGLTKDVWSKYQKDKKNYKELELLRQVYYGGVEHEIRKDVWPFLLGHYKFGMSKKEMEQVDAAVA 645

  Fly   652 HYYETTMSEWLAVDAIVQQREKEKTARAVAKLSSGSNSGNDRTVRAADLEAGGDLENEVFEDISD 716
            ..|:..::||.|.:.:|:|||:|.....:.|.||||:.  |..|:.. :.....:.|:||..:.|
  Rat   646 ARYQQVLAEWKACEVVVRQREREAHPATLTKFSSGSSI--DSHVQRL-VHRDSTISNDVFISVDD 707

  Fly   717 ISDPGDLEFDEQQQQQQQQAECAVSGNHLTVKPIPRAMKTSTDSGHVDESFNELDEPDEEDNKQK 781
            :..||..:.::.:.:|:::......|                                   ....
  Rat   708 LEPPGPQDPEDSKPKQEREPGAGTPG-----------------------------------TAAA 737

  Fly   782 QQQDEKISESESKLPDYRKLEEQINQEPSCSASTASSYETVGPGEVHQRPNSDTRSVLSPEYLSA 846
            :||..:....:|.||..|........:.|...:.:..:|..|.||    ..|:..:..:..:|..
  Rat   738 EQQSVEFESPDSGLPSSRNYSVASGIQSSLDEAQSVGFEEDGAGE----EGSEEPATAAHTFLGP 798

  Fly   847 DDLQLPDDEDAVRPPPPPAAAAVIITKASVDITNWERSPKAAEGDQMSPLEEQAGESGGAGVNMD 911
            .|   ||.|                                    :::|..|..|     |..:.
  Rat   799 HD---PDQE------------------------------------KLAPASELEG-----GEELT 819

  Fly   912 ALQQPKSACASPASSNGGVYSSELLEQFGLNLHRIEKDVQRCDRNYWYFANENLDKLRNVISTYV 976
            |:      ||:       .|:.|||:...||||||:|||||||||||||...||::||:::.:||
  Rat   820 AV------CAA-------TYTIELLDTVALNLHRIDKDVQRCDRNYWYFTTPNLERLRDIMCSYV 871

  Fly   977 WEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKLMERMIENFPSGGAMDMHFANMRSLIQILD 1041
            |||||:||:||||||:||||||.|::.|:||||..||:||.:|||:|||||.|||||||||||||
  Rat   872 WEHLDMGYVQGMCDLLAPLLVILDNDQLAYSCFSHLMKRMSQNFPNGGAMDTHFANMRSLIQILD 936

  Fly  1042 SEMYDLMDSNGDYTHFYFCYRWFLLDFKRELVYDDVFATWEVIWAAKHIASGHFVLFLALALLET 1106
            ||:::||..||||||||||||||||||||||:|::|||.|||||||:||:|.|||||:||||:|.
  Rat   937 SELFELMHQNGDYTHFYFCYRWFLLDFKRELLYEEVFAVWEVIWAARHISSEHFVLFIALALVEA 1001

  Fly  1107 YRDIILSNSMDFTDVIKFFNEMAERHNAQSVLQLARSLVLQLQMIIENK 1155
            ||:||..|:|||||:||||||.||||:||.:|::||.||.::||:|:||
  Rat  1002 YREIIRDNNMDFTDIIKFFNERAERHDAQEILRIARDLVHKVQMLIDNK 1050

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_608395.6	RUN_SGSM1_like	21..214	CDD:439049	80/192 (42%)
		PH_RUTBC	292..466	CDD:275431	98/179 (55%)
		TBC	923..1087	CDD:214540	114/163 (70%)
Sgsm2	NP_001427045.1	None