DRSC/TRiP Functional Genomics Resources

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Protein Alignment tbc and Tbc1d25

DIOPT Version :10

Sequence 1:NP_608395.6 Gene:tbc / 318059 FlyBaseID:FBgn0052506 Length:1155 Species:Drosophila melanogaster
Sequence 2:NP_001100425.1 Gene:Tbc1d25 / 302552 RGDID:1559711 Length:688 Species:Rattus norvegicus


Alignment Length:556 Identity:98/556 - (17%)
Similarity:174/556 - (31%) Gaps:255/556 - (45%)


- Green bases have known domain annotations that are detailed below.


  Fly   830 RPNSDTR-----SVLSPEYLSADDLQLPDDEDAVRPPPPPAAAAVI------ITKASVDITNWER 883
            ||:.|:.     .::||:.:...|:.|.|...::.....|...:::      ::|.. .:.:|  
  Rat   125 RPSEDSPLLEDWDIISPKDVIGSDVLLADKRSSLTTAALPFTQSILSQVGRTLSKVQ-QVLSW-- 186

  Fly   884 SPKAAEGDQMSPLEEQAGESGGAGVNMDALQQPKSACASPAS-----SNGGVYSS--ELLEQFGL 941
                :.|:.:.|.:....::     ........:...:.|..     .:|||..|  :::.::.|
  Rat   187 ----SYGEDVKPFKPPLSDA-----EFHTYLNHEGQLSRPEELRLRIYHGGVEPSLRKVVWRYLL 242

  Fly   942 NLH-----------------------------------------RIEKDVQRCDRNYWYFA---- 961
            |::                                         .:.|||.|.||.:.|:|    
  Rat   243 NVYPDGLTGRERMDYMKRKSREYEQLKSEWAQRVNPEDLEFIRSTVLKDVLRTDRAHPYYAGPED 307

  Fly   962 NENLDKLRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKLMERMIENF-PSGGA 1025
            ..:|..|.::::||...|..|.|.|||.||.:|:|.:.|.|..::.|||.:|:|:..|| |.|.|
  Rat   308 GPHLRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMDHEGHAFVCFCGIMKRLAANFHPDGRA 372

  Fly  1026 MDMHFANMRSLIQILDSEMYD-LMDSNGDYTHFYFCYRWFLLDFKRELVYDDVFATWEVIW---- 1085
            |...||:::.|::..|.:.|. |.::..|  ..:|||||.||:.|||..:||.....||.|    
  Rat   373 MATKFAHLKLLLRHADPDFYQYLQEAGAD--DLFFCYRWLLLELKREFAFDDALRMLEVTWSSLP 435

  Fly  1086 ------------------------------------------------AAKHIASGH-------- 1094
                                                            |..|:|:..        
  Rat   436 PDPPEHEVELVGPPSQVADTGFGSHRGRPVRQRHMLRPAGGGSSAFEDAVVHLATSSQGPSSGGR 500

  Fly  1095 ----------------------------------------------------------------- 1094
                                                                             
  Rat   501 LLRQASLDGLQQLRDNMSPRKDLLVQLSHPATLISSKSLSEPLLNSPDPLLSSSSRPDSPSSSSP 565

  Fly  1095 ---------------------------------------------------FVLFLALALLETYR 1108
                                                               |:|||.||:|..:|
  Rat   566 PSTQEASPSGDVAVGSPSMPEVGSPRDPGKSVPPPPPMGLPPPQEFGRGNPFMLFLCLAILLEHR 630

  Fly  1109 DIILSNSMDFTDVIKFFNEMAERHNAQSVLQLARSL 1144
            |.|:.|.:|:.::...|:.:..:|:...||:.|::|
  Rat   631 DHIMRNGLDYNELAMHFDRLVRKHHLGRVLRRAKAL 666

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tbcNP_608395.6 RUN_SGSM1_like 21..214 CDD:439049
PH_RUTBC 292..466 CDD:275431
TBC 923..1087 CDD:214540 64/269 (24%)
Tbc1d25NP_001100425.1 TBC 225..454 CDD:214540 63/230 (27%)
Blue background indicates that the domain is not in the aligned region.

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