DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment tbc and Rabgap1l

DIOPT Version :9

Sequence 1:NP_001285494.1 Gene:tbc / 318059 FlyBaseID:FBgn0052506 Length:1155 Species:Drosophila melanogaster
Sequence 2:XP_006496938.1 Gene:Rabgap1l / 29809 MGIID:1352507 Length:1051 Species:Mus musculus


Alignment Length:1008 Identity:189/1008 - (18%)
Similarity:330/1008 - (32%) Gaps:367/1008 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   269 SFKSIASASVAKDYVESLHQNAKATLLYGKNNVQVLPKDVAEPMPGYLSLHQHIQTLTIKWTPNQ 333
            ||:.::.:|   |.|.:|  |::..:|..::......||..:|.....|                
Mouse     6 SFQKVSGSS---DSVATL--NSEEFVLVSQHTDATSIKDDGKPQLKIAS---------------- 49

  Fly   334 LMNGYTEAEEA-EDIDKDAFWAYALNINVDEIVYVHCHQSR-------GE--------------- 375
              ||..:.|:| |:|.:|:....: .:.||      |..|.       |:               
Mouse    50 --NGDEQLEKAMEEILRDSEKGQS-GLPVD------CQGSSEISDCPFGDVPASQTTKPPLQLIL 105

  Fly   376 DSGGTVILVGQDGVQRP--PIHFPEGG----HMQQFLSCLETGLLPHGQLDPPLWSQRGIGKM-- 432
            |...|.|     ...||  |..|||..    :...:|.|::.. .|..:::    :.|.:..|  
Mouse   106 DPSNTEI-----STPRPSSPSRFPEEDSVLFNKLTYLGCMKVS-SPRSEVE----ALRAMATMRA 160

  Fly   433 -FLWPRSMRRRILPSVME-SVDETPIDYVFRIVSKSRHEEFAA--THSILDFVRSTPRRAQLSSC 493
             ..:|.::...: |:|.| ||         ||:.:|.:.|.|:  .:.:|...|.....|: |:|
Mouse   161 SSQYPFAVTLYV-PNVPEGSV---------RIIDQSSNVEIASFPIYKVLFCARGHDGTAE-SNC 214

  Fly   494 STTGSSDCSNKSLSIDQFPMESPLILQQQQQQQQQLLQAQSTSIEMVCSTMRRQIISRAFYGWLA 558
            .....|...::...|..|..|              :.:|.|..:...|:..:|.           
Mouse   215 FAFTESSHGSEEFQIHVFSCE--------------IKEAVSRILYSFCTAFKRS----------- 254

  Fly   559 YCRHLSTVRTHLSGLVHGRITPEMKADEEGLTKERWQLLNVNGVLENATEFYRLVYFGGVQPELR 623
             .|.:|.|:        ..:.|...:|                           |:...|..|::
Mouse   255 -SRQVSDVK--------DSVIPTPDSD---------------------------VFTFSVSLEVK 283

  Fly   624 QEVWPYLLGHYAFGSTTEDRKKQDETCKHYYETTMSEWLAVDAIVQQREKEKTA--RAVAKLSSG 686
            ::.     |...|....:||.      |.|::........|...|||...::.|  |....|.|.
Mouse   284 EDD-----GKGNFSPVPKDRD------KFYFKIKQGIEKKVVITVQQLSNKELAIERCFGMLLSP 337

  Fly   687 SNSGNDRTVRAADLEAGG---DLENEVFEDISDISDPGDLEFDEQQQQQQQQAECAVSGNHLTVK 748
            ..:..:..:...|:|:.|   |....|...:.:.:.|..|..:|:..:.::.        ::||.
Mouse   338 GRNVKNSDMHLLDMESMGKSYDGRAYVITGMWNPNAPIFLALNEETPKDKRV--------YMTVA 394

  Fly   749 PIPRAMKTSTDSGHVDESFNELDEPDE---EDNKQKQQQDE----------------KISESESK 794
                          ||....|:.||..   |...:....:|                ::.:||.|
Mouse   395 --------------VDMVVTEVVEPVRFLLETVVRVYPANERFWYFSRKTFTETFFMRLKQSEGK 445

  Fly   795 LPDYRKLEEQINQEPSCSASTASSYETVGPGEVHQRPNSDTRSVLSPEYLSADDLQLPDDEDAVR 859
                           ..|::..:.||.|                           .|..:.|...
Mouse   446 ---------------GHSSAGDAIYEVV---------------------------SLQRESDKEE 468

  Fly   860 PPPPPAAAAVIITKASVDITNWERSPKAAEGDQMSPLEEQAGE-------SGGAGVNMDALQ--- 914
            |..|.:|                       |..|||.|::|.|       ||...|:.|..:   
Mouse   469 PITPTSA-----------------------GGPMSPQEDEAEEESDNELSSGTGDVSKDCPEKIL 510

  Fly   915 ----------------QPKS-----ACASPASSNGGVY--------SSELLEQFGLNLHR----- 945
                            :||.     ....|.:....|:        :.|:|:::.:.:.:     
Mouse   511 YSWGELLGRWHNNLGGRPKGLFTLVKSGVPEALRAEVWQLLAGCHDNQEMLDKYRILITKDSAQE 575

  Fly   946 --IEKDVQRCDRNYWYF---ANENLDKLRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESLS 1005
              |.:|:.|....:.||   ..:..:.|..:...|.....|:||.||...|.|.||:...:|   
Mouse   576 SVITRDIHRTFPAHDYFKDTGGDGQESLYKICKAYSVFDEDIGYCQGQSFLAAVLLLHMPEE--- 637

  Fly  1006 YSCFC---------KLMERMIENFPSGGAMDMH--FANMRSLIQILDSEMYDLMDSNGDYTHF-- 1057
             ..||         ||.:....||.     |:|  |..:..|:|   .::.||      |:||  
Mouse   638 -QAFCVLVTIMYGYKLRDLYRNNFE-----DLHCKFYQLEKLMQ---EQLPDL------YSHFCD 687

  Fly  1058 ------YFCYRWFLLDFKRELVYDDVFATWEVIWAAKHIASGHFVLF-LALALLETYRDIILSNS 1115
                  .:..:|||..|..:.....||...:::     :..|..::| :|||||:|.::.:|  .
Mouse   688 LNLEAHMYASQWFLTLFTAKFPLCMVFHIIDLL-----LCEGLNIIFHVALALLKTSKEDLL--Q 745

  Fly  1116 MDFTDVIKFFN-EMAERHNAQSVLQLARSLVLQ 1147
            .||...:|||. ::.:|:.|:   :.||.|:.|
Mouse   746 ADFEGALKFFRVQLPKRYRAE---ENARRLMEQ 775

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tbcNP_001285494.1 RUN 45..218 CDD:280855
PH_RUTBC 292..466 CDD:275431 39/206 (19%)
TBC 923..1087 CDD:214540 43/200 (22%)
Rabgap1lXP_006496938.1 PTB_Rab6GAP 129..257 CDD:269922 29/169 (17%)
DUF3694 290..421 CDD:372133 29/158 (18%)
RabGAP-TBC 541..744 CDD:366170 50/225 (22%)
Smc <814..>1019 CDD:224117
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5210
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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