DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tbc and Tbc1d17

DIOPT Version :9

Sequence 1:	NP_001285494.1	Gene:	tbc / 318059	FlyBaseID:	FBgn0052506	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_001099728.1	Gene:	Tbc1d17 / 292886	RGDID:	1309686	Length:	646	Species:	Rattus norvegicus

Alignment Length:	587	Identity:	146/587 - (24%)
Similarity:	228/587 - (38%)	Gaps:	156/587 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   638 STTEDRKKQDETCKHYYETTMSEWLAVDAIVQQREKEKTARAVAKLSSGSNS-------GNDRTV 695
            ||:|    ::.|....||   .:| ||.:.|:.|......|..|:.||..:|       |..:::
  Rat    73 STSE----EEPTFDPGYE---PDW-AVISTVRPRPHLAEPRRGAEPSSPRSSWAFSVSLGELKSI 129

  Fly   696 RAAD-----------LEAGGDLENEVFEDISDISDPGDLEFDEQQQQQQQQAECAVSGNHLTVKP 749
            |.:.           .:|||.|             |. |.|    .:...:|...|...:|.:..
  Rat   130 RRSKPGLSWAYLVLVTQAGGSL-------------PA-LHF----HRGGTRALLRVLSRYLLLAS 176

  Fly   750 IPRAMKT----STDSGHVDESFNELDEPDEEDNKQKQQQDEKISESESKLPDYRKLEEQINQEPS 810
            .|:..:.    ..|...:.:||:.|...|:                     |...:..:..|:|
  Rat   177 SPQDSRLYLVFPQDPSALSDSFHHLQLFDQ---------------------DSSNVVSRFLQDP- 219

  Fly   811 CSASTASSYETV-----GPGEVHQRPNSDTRSVLSPEYLSADDL-QLPDDEDAVRPPPPPAAAAV 869
             .::|.||:..|     |..:.|            ||..|:.|| .|||||      |.|....:
  Rat   220 -YSTTFSSFSRVTNFFRGALQPH------------PEGASSPDLPPLPDDE------PEPGFEVI 265

  Fly   870 IITKASVDITNWERSPKAAEGD-----------QMSPLEEQAGESGG--AGVNMDALQ------- 914
            ...:.....| .||:|...|.:           |..|..:....|||  .|:..:|.:
  Rat   266 SCVELGQRPT-VERAPPVTEEEWNRHVGPEGRLQNVPELKSRIFSGGLSPGLRREAWKFLLGYLS 329

  Fly   915 ------------------------QPKSACASPASSNGGVYSSELLEQFGLNLHRIEKDVQRCDR 955
                                    |.||..|.....|..::....|         ||:||.|.||
  Rat   330 WESSAEEHKAHVRKKTDEYFRMKLQWKSVSAEQERRNSLLHGYRSL---------IERDVSRTDR 385

  Fly   956 -NYWYFANEN--LDKLRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKLMERMI 1017
             |.:|...||  |..|.:::.||...|.|:||:|||.||::|:|.:..:|..::.|||..||.:.
  Rat   386 TNKFYEGPENPGLGLLNDILLTYCMYHFDLGYVQGMSDLLSPILFVVQNEVDAFWCFCGFMELVH 450

  Fly  1018 ENF-PSGGAMDMHFANMRSLIQILDSEMYDLMDSNGDYTHFYFCYRWFLLDFKRELVYDDVFATW 1081
            .|| .|...|......:..|:::||..:.|.:||. |.....||:||.|:.||||..:.||...|
  Rat   451 GNFEESQETMKRQLGQLLLLLRVLDQPLCDFLDSQ-DSGSLCFCFRWLLIWFKREFPFPDVLRLW 514

  Fly  1082 EVIWAAKHIASGHFVLFLALALLETYRDIILSNSMDFTDVIKFFNEMAERHNAQSVLQLARSLVL 1146
            ||:|..  :...:..|.:|.|:|:..||.::.:.....:::|..||:..:.:.:.||..|.:|..
  Rat   515 EVLWTG--LPGPNLHLLVACAILDMERDTLMLSGFGSNEILKHINELTMKLSVEDVLTRAEALYR 577

  Fly  1147 QL 1148
            ||
  Rat   578 QL 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_001285494.1	RUN	45..218	CDD:280855
		PH_RUTBC	292..466	CDD:275431
		TBC	923..1087	CDD:214540	60/167 (36%)
Tbc1d17	NP_001099728.1	DUF3548	3..218	CDD:192931	35/191 (18%)
Tbc1d17	NP_001099728.1	TBC	308..543	CDD:214540	75/246 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810