Protein Alignment tbc and Sgsm1

DIOPT Version :10

• Sequence 1: NP_608395.6
• Gene: tbc / 318059
• FlyBaseID: FBgn0052506
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: XP_063127295.1
• Gene: Sgsm1 / 288743
• RGDID: 1308178
• Length: 1148
• Species: Rattus norvegicus
• Alignment Length: 1250
• Identity: 550/1250 - (44%)
• Similarity: 736/1250 - (58%)
• Gaps: 212/1250 - (16%)

  Fly     9 SDYKERLIASVKKEVKQLMEEAVTKKYVHEESSSVTSLCGAVEACLSQGLRRRALGLFKTSSTTA 73
            ::.::||:.:|||||||:||||||:|:|||:||.:.|.|.|||||:..||||||.|..:::...|
  Rat     8 AETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLRRRAAGFLRSNKIAA 72

  Fly    74 LLHKIAKSCPEAEHISKLVQEIEASDPSKRS--SSSSDSFQRPPMLKKSSSNSMSTGTNAAASTS 136
            |..|:.|..|.||.:|:.|||:|....|.|:  ....::.::.|.|
  Rat    73 LFMKVGKGFPPAEELSRKVQELEQLIESARNQIQGLQENVRKLPKL------------------- 118

  Fly   137 SASASISVSASTSSMSLASMKYLWIRLALYEKRLTKIIEYLVSNASSFYDRDSLVADSDYGSILS 201
                        .::|..::|:||||.||:|:.|.||:.|||.|:|.:|::::|:.|...|.||:
  Rat   119 ------------PNLSPLAIKHLWIRTALFERVLDKIVHYLVENSSKYYEKEALLMDPVDGPILA 171

  Fly   202 SLLVGPCALEFTRAKTADHYWTDPHADELVQRHRI-SSCRRSSSTCSRPAIINFKRSLNTSSDEA 265
            ||||||||||:|:.|||||:||||.|||||||||| ||..|..|...|||:...||..:.|.|:.
  Rat   172 SLLVGPCALEYTKMKTADHFWTDPSADELVQRHRIHSSHLRQDSPTKRPALCIQKRHSSGSMDDR 236

  Fly   266 GTGSFKSIASASVAKDYVESLHQNAKATLLYGKNNVQVLPKDVAEPMPGYLSLHQHIQTLTIKWT 330
            .:.|         |:|||||||||::||||||||||.|.|:|..|.:||||||||....:|:|||
  Rat   237 PSIS---------ARDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWT 292

  Fly   331 PNQLMNGYTEAEEAEDID--KDAFWAYALNINVDEIVYVHCHQSRGEDSGGTVILVGQDGVQRPP 393
            |||||||     ...|:|  |..:|.||:.|.::||||:||||.  .||||||:||.|||:||||
  Rat   293 PNQLMNG-----SVGDLDYEKSVYWDYAVTIRLEEIVYLHCHQQ--VDSGGTVVLVSQDGIQRPP 350

  Fly   394 IHFPEGGHMQQFLSCLETGLLPHGQLDPPLWSQRGIGKMFLWPRSMRRRILPSVMESV-----DE 453
            ..||:|||:.|||||||.|||||||||||||||||.||:|  |: :|:|......||.     |:
  Rat   351 FRFPKGGHLLQFLSCLENGLLPHGQLDPPLWSQRGKGKVF--PK-LRKRSPQGSSESTSSDKEDD 412

  Fly   454 TPIDYVFRIVSKSRHEEF---------------------AATHSILDFVRS-------------- 483
            ...||||||:......||                     ||.||:|...|.
  Rat   413 EATDYVFRIIYPGTQSEFVTLDLLGSPRPMSVGPAWMMLAAGHSVLVVARGLQWAQTRGCQTVPT 477

  Fly   484 ---------------------------TPRRAQLSSCSTTGSSD-CSNKSLSIDQFPMESPLILQ 520
                                       :||::..||||.:||:| .|....:.::.|
  Rat   478 RSVKEQPPMPQDLMDVSMNNLPSLWQPSPRKSSCSSCSQSGSADGSSTNGCNHERAP-------- 534

  Fly   521 QQQQQQQQLLQAQSTSIEMVCSTMRRQIISRAFYGWLAYCRHLSTVRTHLSGLV-HGRITPEMKA 584
                            ::::|..|:.||:||||||||||||||||||||||.|| |..::|::..
  Rat   535 ----------------LKLLCDNMKYQILSRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPC 583

  Fly   585 DE-EGLTKERWQLLNVNGVLENATEFYRLVYFGGVQPELRQEVWPYLLGHYAFGSTTEDRKKQDE 648
            |. :|||...|:....:.......|..||:|:||||||:|:.|||:|||||.||.|..:||:.||
  Rat   584 DAGQGLTASIWEQYIQDSTTYPEQELLRLIYYGGVQPEIRRAVWPFLLGHYQFGMTEMERKEVDE 648

  Fly   649 TCKHYYETTMSEWLAVDAIVQQREKEKTARAVAKLSSGSNSGN--------DRTV---------- 695
            .....|..||||||..:|||:|||:|..|.|:||.|||::..:        |.|:
  Rat   649 QIHACYAQTMSEWLGCEAIVRQRERESHAAALAKCSSGASLDSHLHRMLHRDSTISNESSQSCSS 713

  Fly   696 --RAADLEAGGDLENEVFEDISDISDPGDLEFDEQQQQQQQQAECAVSGNHLTVKPIPRAMKTST 758
              :...|::......:|||.:.::      |..|.:.:.:::.....:||       |.....|.
  Rat   714 GRQNLRLQSDSSSSTQVFESVDEV------EQTEAEGRSEEKHPKIPNGN-------PANGTCSP 765

  Fly   759 DSGHVDESFNELDEPDEEDNKQKQQQDEKISESESKLPD-YRKLEEQINQEPSCSASTASSYETV 822
            ||||  .|.:.......|.::.....::.:.:.:..||. :|..:..:....|..|:|:   ...
  Rat   766 DSGH--PSSHNFSSGLSEHSEPSLSTEDSVLDVQRSLPAVFRPGDSSVEDGQSSEATTS---RDE 825

  Fly   823 GPGE---VHQRPNSDTRSVLS-PEYLSAD---DLQLPDDEDAVRPPPPPAAAAVIITKASVDITN 880
            .|.|   |.....||..:..| .|::|..   |:.||:.:.|:....|..|
  Rat   826 APREELAVQDSLESDLLANESLEEFMSIPGSLDVALPEKDGAMMDGWPGEA-------------- 876

  Fly   881 WERSPKAAEGDQMSPLEEQAGESGGAGVNMDALQQPKSACASPASSNGGVYSSELLEQFGLNLHR 945
             ::..:|...|.:|  ||...||....:...|:....:...||.||:|..||.|||:.:.:||||
  Rat   877 -DKHGRADSEDNLS--EEPEMESLFPALASLAVTSSANNETSPVSSSGVTYSPELLDLYTVNLHR 938

  Fly   946 IEKDVQRCDRNYWYFANENLDKLRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFC 1010
            ||||||||||:||||...||:||||::.:|:|:|:::||:||||||:||||||.|||:|::|||.
  Rat   939 IEKDVQRCDRSYWYFTAANLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFT 1003

  Fly  1011 KLMERMIENFPSGGAMDMHFANMRSLIQILDSEMYDLMDSNGDYTHFYFCYRWFLLDFKRELVYD 1075
            :||:||.:|||.|||||.|||||||||||||||:::||..|||||||||||||||||||||||||
  Rat  1004 ELMKRMNQNFPHGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYD 1068

  Fly  1076 DVFATWEVIWAAKHIASGHFVLFLALALLETYRDIILSNSMDFTDVIKFFNEMAERHNAQSVLQL 1140
            |||:.||.||||||::|.|:|||:||||:|.||||||.|:|||||:|||||||||||||:.:|||
  Rat  1069 DVFSVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNAKQILQL 1133

  Fly  1141 ARSLVLQLQMIIENK 1155
            ||.||.::|::||||
  Rat  1134 ARDLVHKVQILIENK 1148

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_608395.6	RUN_SGSM1_like	21..214	CDD:439049	80/194 (41%)
		PH_RUTBC	292..466	CDD:275431	107/180 (59%)
		TBC	923..1087	CDD:214540	118/163 (72%)
Sgsm1	XP_063127295.1	None