DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tbc and TBC1D10B

DIOPT Version :9

Sequence 1:	NP_001285494.1	Gene:	tbc / 318059	FlyBaseID:	FBgn0052506	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_056342.3	Gene:	TBC1D10B / 26000	HGNCID:	24510	Length:	808	Species:	Homo sapiens

Alignment Length:	366	Identity:	75/366 - (20%)
Similarity:	123/366 - (33%)	Gaps:	112/366 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   808 EPSCSASTASSYETVGPGEVHQRPNS-DTRSVLSPEYLSADDLQ-LPDDEDAVRPPPPPAAAAV- 869
            ||:.::....|..::|||....|..: ||.|.|....|.:..|: |.||..::.........|:
Human   238 EPAENSQDLGSTSSLGPGISGPRGQAPDTLSYLDSVSLMSGTLESLADDVSSMGSDSEINGLALR 302

  Fly   870 ----------------IITKASVDI------------TNWERSPKAAEGDQMSPLEEQAGESGGA 906
                            :.:...||:            :||::.           |..:
Human   303 KTDKYGFLGGSQYSGSLESSIPVDVARQRELKWLDMFSNWDKW-----------LSRR------- 349

  Fly   907 GVNMDALQQPKSACAS--PASSNGGVY-----SSELLEQFGLN----------------LHRIEK 948
                  .|:.|..|..  |:|.....:     |.|||||   |                |..|||
Human   350 ------FQKVKLRCRKGIPSSLRAKAWQYLSNSKELLEQ---NPGKFEELERAPGDPKWLDVIEK 405

  Fly   949 DVQRCDRNYWYFA---NENLDKLRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFC 1010
            |:.|....:..||   ......|..::..|.....|.||.|....:.|.||:....|. ::.|..
Human   406 DLHRQFPFHEMFAARGGHGQQDLYRILKAYTIYRPDEGYCQAQAPVAAVLLMHMPAEQ-AFWCLV 469

  Fly  1011 KLMERMIENFPSGGAMDMHFANMRSLIQILDSEM-YDLMDSNGDYTHFY----------FCYRWF 1064
            ::.::.:..:.|.|.         ..|| ||.|: :.|:.......|.:          :...||
Human   470 QICDKYLPGYYSAGL---------EAIQ-LDGEIFFALLRRASPLAHRHLRRQRIDPVLYMTEWF 524

  Fly  1065 LLDFKRELVYDDVFATWEVIWAAKHIASGHFVLF-LALALL 1104
            :..|.|.|.:..|...|::.:     ..|..::| :||.||
Human   525 MCIFARTLPWASVLRVWDMFF-----CEGVKIIFRVALVLL 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_001285494.1	RUN	45..218	CDD:280855
		PH_RUTBC	292..466	CDD:275431
		TBC	923..1087	CDD:214540	44/198 (22%)
TBC1D10B	NP_056342.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..38
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..225
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	237..264		7/25 (28%)
		TBC	357..562	CDD:214540	51/223 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	629..808
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900