Protein Alignment tbc and gyp7

DIOPT Version :10

• Sequence 1: NP_608395.6
• Gene: tbc / 318059
• FlyBaseID: FBgn0052506
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: NP_592900.1
• Gene: gyp7 / 2543609
• PomBaseID: SPAC630.05
• Length: 743
• Species: Schizosaccharomyces pombe
• Alignment Length: 999
• Identity: 182/999 - (18%)
• Similarity: 327/999 - (32%)
• Gaps: 433/999 - (43%)

  Fly   278 VAKDYVESLHQNAKATLLYGKNNVQVLP-KDVAEPMPGYLSLHQHI---------QTLTIKWTPN 332
            |..|.|:....|:|..||:.|:.|.|.| ..:.:.:.|||||.:..         ..:.:.|.|:
pombe    15 VEDDTVDIHIDNSKVALLFSKSKVFVHPTSKMKDNISGYLSLSKSKALGNSSVAGSDILLSWVPD 79

  Fly   333 QLMNG----YTEAEEAEDIDKDAF--WA-------YALNINVDEIVYVHCHQSR-GEDSGGTVIL 383
            ..:..    .:..:.||.:...:.  |.       |:.::.:..|..:.....| |.:.|..||.
pombe    80 SFLKNRPRDLSVFQNAETLSNGSIREWVEIPQHLDYSFSVRLCSIYSIIFRPPRYGWNYGSIVIN 144

  Fly   384 VGQDGVQRPPIHFPEGGHMQQFLSCLETG-LLPHGQLDPPLWSQRGIGKMFLWPRS---MRRRIL 444
            :...|...||:.|    |..:.:|.:|.| .:...:.||...|    |.|| |..:   |:.:..
pombe   145 LRDSGESLPPLFF----HDDECISTIEYGKQITRDRFDPFDES----GNMF-WGGTHLLMQLKKY 200

  Fly   445 PSVMES--------VDETPIDYVF-------RIVSKSRHEEFAATHSILDFVRSTP--------- 485
            .|:.:|        |:.:|.|.|.       :::|.:|...           .|||
pombe   201 ASLEQSSHESQLYLVNPSPEDTVAFQSVELQKVISNNRLNS-----------SSTPPTPRSSSSI 254

  Fly   486 ----RRA----------QLSSCSTTGSSDCS-------NKSLSIDQFPMESPLILQQQQQQQQQL 529
                |||          :.|..:..|.|:..       .||: :...|.|..::|  :.::.|:|
pombe   255 FNPFRRALHDLSFTVLERFSRVTNYGKSEVDRLMEHKVTKSI-LPHLPRELQVLL--ESKRVQKL 316

  Fly   530 LQAQSTSIEMVCSTMRRQIISRAFYGWLAYCRHLSTVRTHLSG-----------------LVHGR 577
            .:....:         |..::|...|.:......::...:.:|                 ||:
pombe   317 TEEYDPA---------RMFLARWAEGIVEQSESNNSQPVNNAGVWTDAQREEDSSLGPFELVY-- 370

  Fly   578 ITPEMKADEEGLTKERW-QLLNVNGVLENATEFYR---LVYFGGVQPELRQEVWPYLLGHYAFGS 638
            |...:|.|:. |:.|:| .:.|.:|.|:  .:.:|   :::.||:||.||:||||:||..|.:.|
pombe   371 IEERVKRDDP-LSVEQWNSMFNAHGKLQ--VDVHRVLGIIFHGGIQPSLRKEVWPFLLSVYPWDS 432

  Fly   639 TTEDRK-----KQDETCKHYYETTMSEWLAVDAIVQQREKEKTARAVAKLSSGSNSGNDRTVRAA 698
            |:|:|:     .|:|.|     |...:|
pombe   433 TSEERRVIYLSLQEEYC-----TLKRKW------------------------------------- 455

  Fly   699 DLEAGGDLENEVFEDISDISDPGDLEFDEQQQQQQQQAECAVSGNHLTVKPIPRAMKTSTDSGHV 763
                        :|||
pombe   456 ------------YEDI------------------------------------------------- 459

  Fly   764 DESFNELDEPDEEDNKQKQQQDEKISESESKLPDYRKLEEQINQEPSCSASTASSYETVGPGEVH 828
            .:.||:
pombe   460 HKQFND----------------------------------------------------------- 465

  Fly   829 QRPNSDTRSVLSPEYLSADDLQLPDDEDAVRPPPPPAAAAVIITKASVDITNWERSPKAAEGDQM 893
                                                               .|
pombe   466 ---------------------------------------------------RW------------ 467

  Fly   894 SPLEEQAGESGGAGVNMDALQQPKSACASPASSNGGVYSSELLEQFGLNLHRIEKDVQRCDRNYW 958
                                                     .:||    .:||||||.|.||.:.
pombe   468 -----------------------------------------FIEQ----RNRIEKDVHRTDRQHE 487

  Fly   959 YF----------------ANENLDKLRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYS 1007
            ||                .|.|::.:::::.||.....::||:|||.||:||:.|.|:|.:|::.
pombe   488 YFQIEDLPHPDPQSTFTGTNMNMEMMKDILLTYNEYDTELGYVQGMSDLLAPIYVTFNDNALTFW 552

  Fly  1008 CFCKLMERMIENF---PSGGAMDMHFANMRSLIQILDSEMYDLMDSNGDYTHFYFCYRWFLLDFK 1069
            ....||:|:..||   .||  |......:|.||:.:|.|::..::.. |.::.:..:|..|:.||
pombe   553 GMVGLMKRLHFNFLRDQSG--MHRQLDTLRLLIEFMDPELFAHLEKT-DSSNLFCFFRMLLIYFK 614

  Fly  1070 RELVYDDVFATWEVIWAAKHIASGHFVLFLALALLETYRDIILSNSMDFTDVIKFFNEMAERHNA 1134
            ||..::.:...|:|::.  :..|..:.:|:|.|:.|.:|:::|:.:..|.:|:|:|||::.:...
pombe   615 REFDWEVLLKLWDVLFT--NYLSYDYHIFVAYAIAERHREVLLNQTSAFDEVLKYFNELSGKLAL 677

  Fly  1135 QSVLQLARSLVLQLQ---MIIENK 1155
            :..|..|.....|.:   .:|:.|
pombe   678 EPTLICAEQCFYQFKNKLALIDRK 701

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_608395.6	RUN_SGSM1_like	21..214	CDD:439049
		PH_RUTBC	292..466	CDD:275431	46/216 (21%)
		TBC	923..1087	CDD:214540	52/182 (29%)
gyp7	NP_592900.1	PH_RBD	31..>158	CDD:432305	27/130 (21%)
		COG5210	154..739	CDD:227535	152/860 (18%)