DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tbc and gyp7

DIOPT Version :9

Sequence 1:	NP_001285494.1	Gene:	tbc / 318059	FlyBaseID:	FBgn0052506	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_592900.1	Gene:	gyp7 / 2543609	PomBaseID:	SPAC630.05	Length:	743	Species:	Schizosaccharomyces pombe

Alignment Length:	990	Identity:	183/990 - (18%)
Similarity:	325/990 - (32%)	Gaps:	415/990 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   278 VAKDYVESLHQNAKATLLYGKNNVQVLP-KDVAEPMPGYLSLHQHI---------QTLTIKWTPN 332
            |..|.|:....|:|..||:.|:.|.|.| ..:.:.:.|||||.:..         ..:.:.|.|:
pombe    15 VEDDTVDIHIDNSKVALLFSKSKVFVHPTSKMKDNISGYLSLSKSKALGNSSVAGSDILLSWVPD 79

  Fly   333 QLMNG----YTEAEEAEDIDKDAF--WA-------YALNINVDEIVYVHCHQSR-GEDSGGTVIL 383
            ..:..    .:..:.||.:...:.  |.       |:.::.:..|..:.....| |.:.|..||.
pombe    80 SFLKNRPRDLSVFQNAETLSNGSIREWVEIPQHLDYSFSVRLCSIYSIIFRPPRYGWNYGSIVIN 144

  Fly   384 VGQDGVQRPPIHFPEGGHMQQFLSCLETG-LLPHGQLDPPLWSQRGIGKMFLWPRS---MRRRIL 444
            :...|...||:.|    |..:.:|.:|.| .:...:.||...|    |.|| |..:   |:.:..
pombe   145 LRDSGESLPPLFF----HDDECISTIEYGKQITRDRFDPFDES----GNMF-WGGTHLLMQLKKY 200

  Fly   445 PSVMES--------VDETPIDYVF-------RIVSKSRHEEFAATHSILDFVRSTP--------- 485
            .|:.:|        |:.:|.|.|.       :::|.:|...           .|||
pombe   201 ASLEQSSHESQLYLVNPSPEDTVAFQSVELQKVISNNRLNS-----------SSTPPTPRSSSSI 254

  Fly   486 ----RRA----------QLSSCSTTGSSDCS-------NKSLSIDQFPMESPLILQQQQQQQ--- 526
                |||          :.|..:..|.|:..       .||: :...|.|..::|:.::.|:
pombe   255 FNPFRRALHDLSFTVLERFSRVTNYGKSEVDRLMEHKVTKSI-LPHLPRELQVLLESKRVQKLTE 318

  Fly   527 -----QQLLQAQSTSIEMVCSTMRRQIISRAFYGWLAYCRHLSTVRTHLSGLVHGRITPEMKADE 586
                 :..|...:..|.....:...|.::.|.. |....|...:...... ||:  |...:|.|:
pombe   319 EYDPARMFLARWAEGIVEQSESNNSQPVNNAGV-WTDAQREEDSSLGPFE-LVY--IEERVKRDD 379

  Fly   587 EGLTKERW-QLLNVNGVLENATEFYR---LVYFGGVQPELRQEVWPYLLGHYAFGSTTEDRK--- 644
            . |:.|:| .:.|.:|.|:  .:.:|   :::.||:||.||:||||:||..|.:.||:|:|:
pombe   380 P-LSVEQWNSMFNAHGKLQ--VDVHRVLGIIFHGGIQPSLRKEVWPFLLSVYPWDSTSEERRVIY 441

  Fly   645 --KQDETCKHYYETTMSEWLAVDAIVQQREKEKTARAVAKLSSGSNSGNDRTVRAADLEAGGDLE 707
              .|:|.|     |...:|
pombe   442 LSLQEEYC-----TLKRKW---------------------------------------------- 455

  Fly   708 NEVFEDISDISDPGDLEFDEQQQQQQQQAECAVSGNHLTVKPIPRAMKTSTDSGHVDESFNELDE 772
               :|||                                                 .:.||:
pombe   456 ---YEDI-------------------------------------------------HKQFND--- 465

  Fly   773 PDEEDNKQKQQQDEKISESESKLPDYRKLEEQINQEPSCSASTASSYETVGPGEVHQRPNSDTRS 837

pombe   466 ----------------------------------------------------------------- 465

  Fly   838 VLSPEYLSADDLQLPDDEDAVRPPPPPAAAAVIITKASVDITNWERSPKAAEGDQMSPLEEQAGE 902
                                                      .|
pombe   466 ------------------------------------------RW--------------------- 467

  Fly   903 SGGAGVNMDALQQPKSACASPASSNGGVYSSELLEQFGLNLHRIEKDVQRCDRNYWYF------- 960
                                            .:||    .:||||||.|.||.:.||
pombe   468 --------------------------------FIEQ----RNRIEKDVHRTDRQHEYFQIEDLPH 496

  Fly   961 ---------ANENLDKLRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKLMERM 1016
                     .|.|::.:::::.||.....::||:|||.||:||:.|.|:|.:|::.....||:|:
pombe   497 PDPQSTFTGTNMNMEMMKDILLTYNEYDTELGYVQGMSDLLAPIYVTFNDNALTFWGMVGLMKRL 561

  Fly  1017 IENF---PSGGAMDMHFANMRSLIQILDSEMYDLMDSNGDYTHFYFCYRWFLLDFKRELVYDDVF 1078
            ..||   .||  |......:|.||:.:|.|::..::.. |.::.:..:|..|:.||||..::.:.
pombe   562 HFNFLRDQSG--MHRQLDTLRLLIEFMDPELFAHLEKT-DSSNLFCFFRMLLIYFKREFDWEVLL 623

  Fly  1079 ATWEVIWAAKHIASGHFVLFLALALLETYRDIILSNSMDFTDVIKFFNEMAERHNAQSVLQLARS 1143
            ..|:|::.  :..|..:.:|:|.|:.|.:|:::|:.:..|.:|:|:|||::.:...:..|..|..
pombe   624 KLWDVLFT--NYLSYDYHIFVAYAIAERHREVLLNQTSAFDEVLKYFNELSGKLALEPTLICAEQ 686

  Fly  1144 LVLQLQ---MIIENK 1155
            ...|.:   .:|:.|
pombe   687 CFYQFKNKLALIDRK 701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_001285494.1	RUN	45..218	CDD:280855
		PH_RUTBC	292..466	CDD:275431	46/216 (21%)
		TBC	923..1087	CDD:214540	52/182 (29%)
gyp7	NP_592900.1	DUF3548	31..229	CDD:192931	45/206 (22%)
		COG5210	154..739	CDD:227535	153/851 (18%)
		TBC	408..655	CDD:214540	86/521 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22957
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910