Protein Alignment tbc and Tbc1d8b

DIOPT Version :9

• Sequence 1: NP_001285494.1
• Gene: tbc / 318059
• FlyBaseID: FBgn0052506
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: NP_001074968.1
• Gene: Tbc1d8b / 245638
• MGIID: 1918101
• Length: 1114
• Species: Mus musculus
• Alignment Length: 760
• Identity: 141/760 - (18%)
• Similarity: 251/760 - (33%)
• Gaps: 255/760 - (33%)

  Fly   518 ILQQQQQQQQQLLQAQSTSIEMVCSTMRRQIISRAFYGWLA--YCRHLST------VRTHLSGLV 574
            ||.|....|..|        .:.|...|.:|...  :.||.  ..:.||.      :...:.|.:
Mouse    65 ILHQTPDSQVYL--------SIACGANREEITKH--WDWLEQNIMKTLSVFDSNEDITNFVQGKI 119

  Fly   575 HGRITPEMK---ADEEGLTKERWQLLNVNGVL-----ENATEFYRLVYFGGVQPELRQEVWPYL- 630
            .|.|..|.|   |.|:...|.|..||......     |....:|...|:.|..|   .:.|.||
Mouse   120 RGLIAEEGKQSFAKEDDPEKFREALLKFEKSFGLPEQEKLVTYYSCSYWRGRVP---CQGWLYLS 181

  Fly   631 ---LGHYAF--GSTTEDRKKQDETCKHYYETTMSEWLAVDAIVQQREKEKT---ARAVAKLSSGS 687
               |..|:|  ||..:               .:..|.|:..:    ||..|   ..::...|.|.
Mouse   182 TNFLSFYSFLLGSEIK---------------LIISWDAISKL----EKTSTVILTESIHVCSQGE 227

  Fly   688 NS------------------GNDRTVRAADLEAGGDLENE-VFEDISDISDPGDLEFDEQQQQ-- 731
            |.                  .|....|..|.|.   .:|: |.:|...|:..| ||:....:|
Mouse   228 NHYFSMFLHINETYLLMEQLANYAIKRLFDKET---FDNDPVLDDPLQITKRG-LEYRAHSEQFK 288

  Fly   732 ----------QQQQAEC---------------AVSGNHL-----------TVKPIPRAMKTSTDS 760
                      .::..||               .:|.|::           .:.|:...:
Mouse   289 AFFRLPKEETLKEVHECFLWVPFSHFSSHGKMCISENYICFASQDGNLCSVIIPLREVL------ 347

  Fly   761 GHVDESFNELDEPDEEDNKQKQQQDEKISESESKLPDYRKLEEQI-------NQEPSCSASTASS 818
                    .:|:.|:.:.........|.:...|:|.|:.:|..::       :.:...|...|.|
Mouse   348 --------AIDKTDDSNRSVIISIKGKTAFRFSELKDFEQLVAKLRLKCRAASTQDDVSTEVAVS 404

  Fly   819 YETVGPGEVHQRPNSDTRSVLSPEYLSADDLQLPDDEDAVRPPPPPAAAAVIITKASVDITNWER 883
            .::.||.|     |.:.:.:..|:..|                      ..:.|:|.:.:.:
Mouse   405 SDSTGPSE-----NFEEQPLTCPKECS----------------------KTVNTEALMTVFH--- 439

  Fly   884 SPKAAEGDQMSPLEEQAGESG--------GAGVNMDALQQPK-------------------SACA 921
             |:..|......|:|:..|..        |.||:|...::.:                   |...
Mouse   440 -PQNLENLDSKMLKEKMKEQSWNILFSECGRGVSMFRTKKTRDLVVRGIPETLRGELWMLFSGAV 503

  Fly   922 SPASSNGGVYSSELLEQ----FGLNLHRIEKDVQRCDRNYWYFANE-NLDKLRNVISTYVWEHLD 981
            :..::|.|.| :|::||    ..|....||:|::|....:..|.:: .:..||.|::.|.:.:..
Mouse   504 NDMATNPGYY-AEVVEQSLGTSNLATEEIERDLRRSLPEHPAFQSDTGISALRRVLTAYAYRNPK 567

  Fly   982 VGYMQGMCDLVAPLLVIFDDESLSYSCFCKLMERMIENFPSGGAMDMHFANMRSLIQILDSEMYD 1046
            :||.|.| :::..:|:::..|..::.....:.|||:.:          :.|.|.:..::|..:::
Mouse   568 IGYCQAM-NILTSVLLLYAKEEEAFWLLVAVCERMLPD----------YFNRRIIGALVDQAVFE 621

  Fly  1047 ---------LMDSNGDYTHF-YFCYRWFLLDFKREL------------VYDDVFATWEVIWAAKH 1089
                     |.|...|.|.| .....|||..|...|            .||.:.|
Mouse   622 ELIRDHLPQLTDHMTDMTFFSSVSLSWFLTLFISVLPIESAVNVVDCFFYDGIKA---------- 676

  Fly  1090 IASGHFVLFLALALLETYRDIILSNSMD---FTDVIKFFNEMAER 1131
                  :|.|.||:|:...|.:|:...|   .|.:.:||:.:..:
Mouse   677 ------ILQLGLAILDYNLDKLLTCKDDAEAVTALNRFFDNVINK 715

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_001285494.1	RUN	45..218	CDD:280855
		PH_RUTBC	292..466	CDD:275431
		TBC	923..1087	CDD:214540	41/190 (22%)
Tbc1d8b	NP_001074968.1	PH-GRAM1_TBC1D8B	156..254	CDD:275419	22/119 (18%)
		PH-GRAM2_TBC1D8B	296..388	CDD:270159	12/105 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	399..420		6/25 (24%)
		TBC	485..693	CDD:214540	48/235 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	938..957
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1032..1061

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900