Protein Alignment tbc and RABGAP1

DIOPT Version :9

• Sequence 1: NP_001285494.1
• Gene: tbc / 318059
• FlyBaseID: FBgn0052506
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: NP_036329.3
• Gene: RABGAP1 / 23637
• HGNCID: 17155
• Length: 1069
• Species: Homo sapiens
• Alignment Length: 574
• Identity: 123/574 - (21%)
• Similarity: 220/574 - (38%)
• Gaps: 144/574 - (25%)

  Fly   636 FGSTTEDRKKQ--------DETCKHYYETTMSEWLAVDAIVQQREKEKTARAVAKLSSGSNSGND 692
            |.:..:|:.:|        |:....|.:.|.::.||::            |....|.|......:
Human   307 FSAVPKDKDRQCFKLRQGIDKKIVIYVQQTTNKELAIE------------RCFGLLLSPGKDVRN 359

  Fly   693 RTVRAADLEAGGDLENEVFEDISDISDPGDLEFDEQQQQQQQQAECAVSGNHLTVKPIPRAMKTS 757
            ..:...|||:.|...:.....|:...:|....|....::              |.|.....|.|:
Human   360 SDMHLLDLESMGKSSDGKSYVITGSWNPKSPHFQVVNEE--------------TPKDKVLFMTTA 410

  Fly   758 TDSGHVDESFNELDEPDE----------EDNKQKQQQDEKISESES---KLPDYRKLEEQINQEP 809
                 ||....|:.||..          ..|::......|.|.:|:   ||...::.|.:.|
Human   411 -----VDLVITEVQEPVRFLLETKVRVCSPNERLFWPFSKRSTTENFFLKLKQIKQRERKNN--- 467

  Fly   810 SCSASTASSYETV---GPGEVHQRPNSDTRSVLSPEYLSADDLQLP----DDEDAVRPPPPPAAA 867
                 |.:.||.|   ...|..:|..:.:.||..|:..|...: :|    |||:.....|
Human   468 -----TDTLYEVVCLESESERERRKTTASPSVRLPQSGSQSSV-IPSPPEDDEEEDNDEP----- 521

  Fly   868 AVIITKASVDITNWERSPKAAE--GDQMSPLEEQAGESGGAGVNMDALQQPKSACA-----SPAS 925
               :...|.|::. |.:.|..|  |:.:|...          :|::.  :||...:     .|.:
Human   522 ---LLSGSGDVSK-ECAEKILETWGELLSKWH----------LNLNV--RPKQLSSLVRNGVPEA 570

  Fly   926 SNGGVY--------SSELLEQFGLNLHR-------IEKDVQRCDRNYWYF---ANENLDKLRNVI 972
            ..|.|:        :..|:|::.:.:.:       |.:|:.|....:.||   ..:..|.|..:.
Human   571 LRGEVWQLLAGCHNNDHLVEKYRILITKESPQDSAITRDINRTFPAHDYFKDTGGDGQDSLYKIC 635

  Fly   973 STYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKLM------ERMIENFPSGGAMDMH-- 1029
            ..|.....::||.||...|.|.||:...:|. ::|...|:|      |...:||.     |:|
Human   636 KAYSVYDEEIGYCQGQSFLAAVLLLHMPEEQ-AFSVLVKIMFDYGLRELFKQNFE-----DLHCK 694

  Fly  1030 FANMRSLIQILDSEMYD-LMDSNGDYTHFYFCYRWFLLDFKRELVYDDVFATWEVIWAAKHIASG 1093
            |..:..|:|....::|: .:|.:.: .|.| ..:|||..|..:.....||...:::     :..|
Human   695 FYQLERLMQEYIPDLYNHFLDISLE-AHMY-ASQWFLTLFTAKFPLYMVFHIIDLL-----LCEG 752

  Fly  1094 HFVLF-LALALLETYRDIILSNSMDFTDVIKFFN-EMAERH----NAQSVLQLA 1141
            ..|:| :||.||:|.:|.:|..  ||...:|||. ::.:|:    ||:.:::||
Human   753 ISVIFNVALGLLKTSKDDLLLT--DFEGALKFFRVQLPKRYRSEENAKKLMELA 804

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_001285494.1	RUN	45..218	CDD:280855
		PH_RUTBC	292..466	CDD:275431
		TBC	923..1087	CDD:214540	43/190 (23%)
RABGAP1	NP_036329.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..79
		PTB_Rab6GAP	145..273	CDD:269922
		DUF3694	307..437	CDD:403614	27/160 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	482..527		11/53 (21%)
		TBC	563..772	CDD:214540	52/221 (24%)
		Smc	<823..>1047	CDD:224117

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810