DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tbc and TBC1D30

DIOPT Version :9

Sequence 1:	NP_001285494.1	Gene:	tbc / 318059	FlyBaseID:	FBgn0052506	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	XP_024304669.1	Gene:	TBC1D30 / 23329	HGNCID:	29164	Length:	944	Species:	Homo sapiens

Alignment Length:	547	Identity:	109/547 - (19%)
Similarity:	190/547 - (34%)	Gaps:	144/547 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   616 GGVQPELRQEVWPYLLGHYAF-GSTTEDRKKQDETCKHYYETTMSEWLAVDAIVQQREKEKTARA 679
            ||.:|.||.|:        .| |...|.|.:..|      |.|:........:....|:.:.:|.
Human     7 GGGRPGLRTEL--------EFRGGGGEARLESQE------EETIPAAPPAPRLRGAAERPRRSRD 57

  Fly   680 VAKLSSGSNSG---NDRTVRAADLEAGGDLENEVFEDISDISDPGDLEFDEQQQQQQQQAECA-- 739
            .......:..|   ..||.|.|.|.:|  |.||::....:....|.....|.:::::...:.:
Human    58 TWDGDEDTEPGEACGGRTSRTASLVSG--LLNELYSCTEEEEAAGGGRGAEGRRRRRDSLDSSTE 120

  Fly   740 VSGNHLTVKPIPRAMKTSTDSGHVDES-FNELDE-PDEEDN----KQKQQQDEKISESESKLPDY 798
            .||:.:.:         ...||..|.. ..||.| |.:...    :||...:.|....|.|   |
Human   121 ASGSDVVL---------GGRSGAGDSRVLQELQERPSQRHQMLYLRQKDANELKTILRELK---Y 173

  Fly   799 R------KLEEQINQ--------EPSCSASTASSYETVGPGEVHQRPNSDT--RSVLSPEYLSAD 847
            |      ||...:.|        :.:|...||...      .|.|:...||  :..|.|. |..:
Human   174 RIGIQSAKLLRHLKQKDRLLHKVQRNCDIVTACLQ------AVSQKRRVDTKLKFTLEPS-LGQN 231

  Fly   848 DLQLPDDEDAVRPP-------PPPAAAAVIITKA-----SVDITNWERSPKAAEGDQMSPLEEQA 900
            ..|  ...||::..       |......|.:|.|     |:.| :|:::.:....::.:|.::..
Human   232 GFQ--QWYDALKAVARLSTGIPKEWRRKVWLTLADHYLHSIAI-DWDKTMRFTFNERSNPDDDSM 293

  Fly   901 GESGGAGVNMDALQQPKSACASPASSNGGVYSSELLEQFGLNLHRIEKDVQR--CDRNYWYFANE 963
            |                                          .:|.||:.|  |.......|.:
Human   294 G------------------------------------------IQIVKDLHRTGCSSYCGQEAEQ 316

  Fly   964 NLDKLRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFD-DESLSYSCFCKLMERMI-ENFPSGG-- 1024
            :...|:.|:..|...:..|||.||...|.|.:|.:.: :|..:......|::::: |::....
Human   317 DRVVLKRVLLAYARWNKTVGYCQGFNILAALILEVMEGNEGDALKIMIYLIDKVLPESYFVNNLR 381

  Fly  1025 AMDMHFANMRSLIQILDSEMYDLMD---------SNGDY----THFYFCYRWFLLDFKRELVYDD 1076
            |:.:..|..|.|:::...|:...:|         |.|.|    |: .|..:|||..|...|....
Human   382 ALSVDMAVFRDLLRMKLPELSQHLDTLQRTANKESGGGYEPPLTN-VFTMQWFLTLFATCLPNQT 445

  Fly  1077 VFATWEVIWAAKHIASGHFVLFLALAL 1103
            |...|:.::    ......:|.::||:
Human   446 VLKIWDSVF----FEGSEIILRVSLAI 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_001285494.1	RUN	45..218	CDD:280855
		PH_RUTBC	292..466	CDD:275431
		TBC	923..1087	CDD:214540	38/182 (21%)
TBC1D30	XP_024304669.1	RabGAP-TBC	296..476	CDD:306939	41/178 (23%)
TBC1D30	XP_024304669.1	DUF4682	637..785	CDD:318030
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900