Protein Alignment tbc and Tbc1d17

DIOPT Version :9

• Sequence 1: NP_001285494.1
• Gene: tbc / 318059
• FlyBaseID: FBgn0052506
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: NP_001036120.1
• Gene: Tbc1d17 / 233204
• MGIID: 2449973
• Length: 645
• Species: Mus musculus
• Alignment Length: 586
• Identity: 143/586 - (24%)
• Similarity: 226/586 - (38%)
• Gaps: 154/586 - (26%)

  Fly   638 STTEDRKKQDETCKHYYETTMSEWLAVDAIVQQ---REKEKTARAVAKLSSGSNS---GNDRTVR 696
            ||:|    ::.|....||   .:|..:..:..|   .|..|.|...:..||.:.|   |..:::|
Mouse    72 STSE----EEPTFDPGYE---PDWAVISTVRPQPHLAEPRKGAEPSSSRSSWAFSVSLGELKSIR 129

  Fly   697 AAD-----------LEAGGDLENEVFEDISDISDPGDLEFDEQQQQQQQQAECAVSGNHLTVKPI 750
            .:.           .:|||.|             |. |.|    .:...:|...|...:|.:...
Mouse   130 RSKPGLSWAYLVLVTQAGGSL-------------PA-LHF----HRGGTRALLRVLSRYLLLASS 176

  Fly   751 PRAMKT----STDSGHVDESFNELDEPDEEDNKQKQQQDEKISESESKLPDYRKLEEQINQEPSC 811
            |:..:.    ..|...:.:||:.|...|:                     |...:..:..|:|
Mouse   177 PQDSRLYLVFPQDPSALSDSFHHLQLFDQ---------------------DSSNVVSRFLQDP-- 218

  Fly   812 SASTASSYETV-----GPGEVHQRPNSDTRSVLSPEYLSADDL-QLPDDEDAVRPPPPPAAAAVI 870
            .::|.||:..|     |..:.|            ||..|:.:| .|||||      |.|....:.
Mouse   219 YSTTFSSFSRVTNFFRGALQPH------------PEGASSPNLPPLPDDE------PEPGFEVIS 265

  Fly   871 ITKASVDITNWERSPKAAEGD-----------QMSPLEEQAGESGG--AGVNMDALQ-------- 914
            ..:.....| .||:|...|.:           |..|..:....|||  .|:..:|.:
Mouse   266 CVELGQRPT-VERAPPVTEEEWNRYVGPEGRLQNVPELKNRIFSGGLSPGLRREAWKFLLGYLSW 329

  Fly   915 -----------------------QPKSACASPASSNGGVYSSELLEQFGLNLHRIEKDVQRCDR- 955
                                   |.||..|.....|..::....|         ||:||.|.||
Mouse   330 ESSAEEHKAHVRKKTDEYFRMKLQWKSVSAEQERRNSLLHGYRSL---------IERDVSRTDRT 385

  Fly   956 NYWYFANEN--LDKLRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKLMERMIE 1018
            |.:|...||  |..|.:::.||...|.|:||:|||.||::|:|.:..:|..::.|||..||.:..
Mouse   386 NKFYEGPENPGLSLLHDILLTYCMYHFDLGYVQGMSDLLSPILFVVQNEVDAFWCFCGFMELVHG 450

  Fly  1019 NF-PSGGAMDMHFANMRSLIQILDSEMYDLMDSNGDYTHFYFCYRWFLLDFKRELVYDDVFATWE 1082
            || .|...|......:..|:::||..:.|.:||. |.....||:||.|:.||||..:.||...||
Mouse   451 NFEESQETMKRQLGQLLLLLRVLDQPLCDFLDSQ-DSGSLCFCFRWLLIWFKREFPFPDVLRLWE 514

  Fly  1083 VIWAAKHIASGHFVLFLALALLETYRDIILSNSMDFTDVIKFFNEMAERHNAQSVLQLARSLVLQ 1147
            |:|..  :...:..|.:|.|:|:..||.::.:.....:::|..||:..:.:.:.||..|.:|..|
Mouse   515 VLWTG--LPGPNLHLLVACAILDMERDTLMLSGFGSNEILKHINELTMKLSVEDVLTRAEALYRQ 577

  Fly  1148 L 1148
            |
Mouse   578 L 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_001285494.1	RUN	45..218	CDD:280855
		PH_RUTBC	292..466	CDD:275431
		TBC	923..1087	CDD:214540	60/167 (36%)
Tbc1d17	NP_001036120.1	DUF3548	3..217	CDD:192931	33/190 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	57..85		4/16 (25%)
		Required for interaction with OPTN. /evidence=ECO:0000250	217..309		25/112 (22%)
		TBC	307..542	CDD:214540	75/246 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	596..645

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810