DRSC/TRiP Functional Genomics Resources

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Protein Alignment tbc and TBC1D9

DIOPT Version :10

Sequence 1:NP_608395.6 Gene:tbc / 318059 FlyBaseID:FBgn0052506 Length:1155 Species:Drosophila melanogaster
Sequence 2:NP_055945.2 Gene:TBC1D9 / 23158 HGNCID:21710 Length:1266 Species:Homo sapiens


Alignment Length:735 Identity:132/735 - (17%)
Similarity:242/735 - (32%) Gaps:249/735 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   539 MVCSTMRRQIISRAFYGW--------LAYCRHLSTVRTHLSGLVHGRITP-----EMKADEE--- 587
            :.|...|::|...  :.|        |:...:.:.:.|.:.|.:.|.|..     ::|.|::   
Human    78 IACGGSRKEITEH--WEWLEQNLLQTLSIFENENDITTFVRGKIQGIIAEYNKINDVKEDDDTEK 140

  Fly   588 ------------GLTKERWQLLNVNGVLENATEFYRLVYFGGVQPELRQEVWPYL-LGHYAFGST 639
                        |:.:|           |....:|...|:.|..|   ::.|.|| :.|..|.|.
Human   141 FKEAIVKFHRLFGMPEE-----------EKLVNYYSCSYWKGKVP---RQGWMYLSINHLCFYSF 191

  Fly   640 TEDR--------------------------KKQDETCKHYYETTMS--------EWLAVDAIVQQ 670
            ...|                          |....:.:|::...::        |.||..|:.|.
Human   192 LMGREAKLVIRWVDITQLEKNATLLLPDVIKVSTRSSEHFFSVFLNINETFKLMEQLANIAMRQL 256

  Fly   671 REKE--KTARAVAKLSSGSNSGNDRTVRAADLEAGGDLENEVFEDISDISDPGDLEFDEQQQQQQ 733
            .:.|  :..|::.||...|........|..|..|..:....:|.      .|.|.:.|       
Human   257 LDNEGFEQDRSLPKLKRKSPKKVSALKRDLDARAKSERYRALFR------LPKDEKLD------- 308

  Fly   734 QQAECA---------------VSGNHL----------------------------TVKPIPRAMK 755
            ...:|.               ||.|::                            :|.|.|.::.
Human   309 GHTDCTLWTPFNKMHILGQMFVSTNYICFTSKEENLCSLIIPLREVTIVEKADSSSVLPSPLSIS 373

  Fly   756 TSTDSGHVDESFNELDEPDEEDNKQKQQQDEKISESESKLPDYRKLEEQINQEPSCSASTASSYE 820
            |......:..:..:.|...:..:...||...||...:.....|...::::...||...|::....
Human   374 TRNRMTFLFANLKDRDFLVQRISDFLQQTTSKIYSDKEFAGSYNSSDDEVYSRPSSLVSSSPQRS 438

  Fly   821 TVGPGEVHQRPNSDTRSVLSPEYLSADDLQLPDDEDAVRPPPPPAAAAVIITKASVDITNWERSP 885
            |....:..::.|.:..||                         |.|...::|...      .|||
Human   439 TSSDADGERQFNLNGNSV-------------------------PTATQTLMTMYR------RRSP 472

  Fly   886 KAAEGDQMSP------LEEQAGE----SGGAGVNMDALQQPKSACAS--PASSNGGV-------- 930
                 ::.:|      |:|||.:    ..|.|:.|...::.:.....  |.|..|.:        
Human   473 -----EEFNPKLAKEFLKEQAWKIHFAEYGQGICMYRTEKTRELVLKGIPESMRGELWLLLSGAI 532

  Fly   931 --------YSSELLE----QFGLNLHRIEKDVQRCDRNYWYFANE-NLDKLRNVISTYVWEHLDV 982
                    |..:|:|    ::.|....||:|:.|....:..|.|| .:..||.|::.|.:.:.::
Human   533 NEKATHPGYYEDLVEKSMGKYNLATEEIERDLHRSLPEHPAFQNEMGIAALRRVLTAYAFRNPNI 597

  Fly   983 GYMQGMCDLVAPLLVIFDDESLSYSCFCKLMERMIENFPSGGAMDMHFANMRSLIQILDSEMYDL 1047
            ||.|.| ::|..:|:::..|..::.....|.|||:.:          :.|.|.:..::|..::: 
Human   598 GYCQAM-NIVTSVLLLYAKEEEAFWLLVALCERMLPD----------YYNTRVVGALVDQGVFE- 650

  Fly  1048 MDSNGDYT-HFYFCYR-----------WFL------LDFKRELVYDDVFATWEVIWAAKHIASGH 1094
             :...||. ..|.|.:           |||      :.|:..:|..|.|           ...|.
Human   651 -ELARDYVPQLYDCMQDLGVISTISLSWFLTLFLSVMPFESAVVVVDCF-----------FYEGI 703

  Fly  1095 FVLF-LALALLETYRDIILS 1113
            .|:| ||||:|:...|.:|:
Human   704 KVIFQLALAVLDANVDKLLN 723

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tbcNP_608395.6 RUN_SGSM1_like 21..214 CDD:439049
PH_RUTBC 292..466 CDD:275431
TBC 923..1087 CDD:214540 43/202 (21%)
TBC1D9NP_055945.2 PH-GRAM1_TCB1D9_TCB1D9B 157..255 CDD:275420 19/111 (17%)
PH-GRAM2_TCB1D9_TCB1D9B 304..399 CDD:270161 11/101 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 415..456 6/40 (15%)
TBC 512..722 CDD:214540 52/233 (22%)
EFh <893..923 CDD:415501
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1075..1095
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1132..1164
Blue background indicates that the domain is not in the aligned region.

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