DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tbc and TBC1D2B

DIOPT Version :9

Sequence 1:	NP_001285494.1	Gene:	tbc / 318059	FlyBaseID:	FBgn0052506	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_001374071.1	Gene:	TBC1D2B / 23102	HGNCID:	29183	Length:	974	Species:	Homo sapiens

Alignment Length:	981	Identity:	187/981 - (19%)
Similarity:	332/981 - (33%)	Gaps:	312/981 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   305 PKDVAEP---MPGYLSLHQHIQTLTIKWTPN-QLMNGYTEAEEAEDIDKDAFWAYALNINV---- 361
            |.:.|||   .|.:..:|. ...:|:...|| |||..:.:..:.:.      |.|..::::
Human    94 PDEAAEPGTEPPAHFQVHS-AGAVTVLKAPNRQLMTYWLQELQQKR------WEYCNSLDMVKWD 151

  Fly   362 -----------------DEIVYVHCHQSRGEDSGGTVI--------LVGQDGVQRPPIHFPE--- 398
                             |....::.|.:...:....|:        |||:....:|....|.
Human   152 SRTSPTPGDFPKGLVARDNTDLIYPHPNASAEKARNVLAVETVPGELVGEQAANQPAPGHPNSIN 216

  Fly   399 -------GGHMQQFLSCLETGLLPHGQLDPPLWSQRGIGKMFLWPRSMRRRIL--PSVMESVDET 454
                   |..::..:|....|              ||       ....||.:.  ....|.:|.|
Human   217 FYSLKQWGNELKNSMSSFRPG--------------RG-------HNDSRRTVFYTNEEWELLDPT 260

  Fly   455 PIDYVFRIVSKSR---------------------HEEFAATHSILDFVRSTPRRAQLSSCSTTGS 498
            |.|....||.:.:                     ...:.....:.|.:.|...|......|:.|:
Human   261 PKDLEESIVQEEKKKLTPEGNKGVTGSGFPFDFGRNPYKGKRPLKDIIGSYKNRHSSGDPSSEGT 325

  Fly   499 SDCSNKSLSIDQFPMESPLILQQQQQQQQQL---LQAQSTSIEMVCSTMRRQIISRAFYGWLAYC 560
            |  .:.|:||.:...|..|.:|.||::.:||   |.:|...:.::..|:|..          .|.
Human   326 S--GSGSVSIRKPASEMQLQVQSQQEELEQLKKDLSSQKELVRLLQQTVRSS----------QYD 378

  Fly   561 RHLSTVRTHLSGLVHGRITPEMKADEEGLTKERWQLLNV--NGVLENATEFYRLVYFGGVQPELR 623
            ::.::.|..                 ||:.|:..:||:.  :.:|...::..|   |...:..|:
Human   379 KYFTSSRLC-----------------EGVPKDTLELLHQKDDQILGLTSQLER---FSLEKESLQ 423

  Fly   624 QEVWPYLLGHYAFGSTTEDRKKQ-DETCKHYYETTMSEWLAVDAIVQQREKEKTARAVAKLSSGS 687
            |||           .|.:.:..: :|......||           :|.:::     .:.|||.|.
Human   424 QEV-----------RTLKSKVGELNEQLGMLMET-----------IQAKDE-----VIIKLSEGE 461

  Fly   688 NSGNDRTV------------------RAADLEAGGDLENEVFEDISDISDPGDLEFDEQQQQQQQ 734
            .:|...||                  |..|...|...:|:...  .:|.:...|..:.:::::..
Human   462 GNGPPPTVAPSSPSVVPVARDQLELDRLKDNLQGYKTQNKFLN--KEILELSALRRNAERRERDL 524

  Fly   735 QAE--------CAVSGNHLTVKPIPRAMKT---STDSGHVDESFNEL--DEPDEEDNKQKQQQDE 786
            .|:        |.:...:|.   :.:.|||   |.|.|...|...:|  |....|..:|.:|...
Human   525 MAKYSSLEAKLCQIESKYLI---LLQEMKTPVCSEDQGPTREVIAQLLEDALQVESQEQPEQAFV 586

  Fly   787 K---ISE-------------SESKLP------DYRKLEEQINQEPSCSASTASSYETVGPGEVHQ 829
            |   :||             .|.||.      |.:.|....|||    .||...:|......|::
Human   587 KPHLVSEYDIYGFRTVPEDDEEEKLVAKVRALDLKTLYLTENQE----VSTGVKWENYFASTVNR 647

  Fly   830 RPNSDTRSVLSPEYLSADDLQLPDDEDAVRPPPPPAAAAVIITKASVDITNWERSPKAAEGDQMS 894
                  ..:.|||..:.....:|.:..:.            :.|..||....:.......|...:
Human   648 ------EMMCSPELKNLIRAGIPHEHRSK------------VWKWCVDRHTRKFKDNTEPGHFQT 694

  Fly   895 PLEEQAGESGGAGVNMDALQQPKSACASPASSNGGVYSSELLEQFGLNLHRIEKDVQRC---DRN 956
            .|::             ||::     .:|||.                  :||.|:.|.   :::
Human   695 LLQK-------------ALEK-----QNPASK------------------QIELDLLRTLPNNKH 723

  Fly   957 YWYFANENLDKLRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKLMERMIENFP 1021
            |....:|.:.|||||:..:.|.:.|:||.||:..|||..|:..:.|. ::.|...::|..
Human   724 YSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALLYLEQED-AFWCLVTIVEVF----- 782

  Fly  1022 SGGAMDMHFANMRSLIQILDSEMY-DLMDSNGDYTHFYF----------CYRWFLLDFKRELVYD 1075
                |...:.....|...:|..:: |||.......|.:|          .:.|||:.|...:|.|
Human   783 ----MPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHGHFEQYKVDYTLITFNWFLVVFVDSVVSD 843

  Fly  1076 DVFATWEVIWAAKHIASGHFVLF-LALALLETYRDIILSNSMDFTDVIKFFNEMAERHNAQSVLQ 1139
            .:|..|:     ..:..|..|:| .||||.: |::..:....|...:.|:.     |:..:::|.
Human   844 ILFKIWD-----SFLYEGPKVIFRFALALFK-YKEEEILKLQDSMSIFKYL-----RYFTRTILD 897

  Fly  1140 LARSLV 1145
             ||.|:
Human   898 -ARKLI 902

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_001285494.1	RUN	45..218	CDD:280855
		PH_RUTBC	292..466	CDD:275431	36/205 (18%)
		TBC	923..1087	CDD:214540	43/177 (24%)
TBC1D2B	NP_001374071.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30
		PH_TBC1D2A	36..144	CDD:269966	14/56 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	272..348		12/77 (16%)
		Smc	<338..552	CDD:224117	48/275 (17%)
		RabGAP-TBC	665..876	CDD:366170	58/274 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900