DRSC/TRiP Functional Genomics Resources

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Protein Alignment tbc and TBC1D9B

DIOPT Version :9

Sequence 1:NP_001285494.1 Gene:tbc / 318059 FlyBaseID:FBgn0052506 Length:1155 Species:Drosophila melanogaster
Sequence 2:NP_942568.2 Gene:TBC1D9B / 23061 HGNCID:29097 Length:1250 Species:Homo sapiens


Alignment Length:774 Identity:152/774 - (19%)
Similarity:270/774 - (34%) Gaps:241/774 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   529 LLQAQSTSI--EMVCSTMRRQIISRAFYGWLA--YCRHLS------TVRTHLSGLVHGRITPEMK 583
            |.|.|.:.:  .:.|.:.|::|...  :.||.  ..:.||      .:.|.:.|.:||.|..|.|
Human    62 LHQTQDSQVYWTVACGSSRKEITKH--WEWLENNLLQTLSIFDSEEDITTFVKGKIHGIIAEENK 124

  Fly   584 -----ADEE-GLTKE-----RWQLLNVNGVLENATEFYRLVYFGGVQPELRQEVWPYL-LGHYAF 636
                 .||: |..||     |.|.....|  |....:|...|:.|..|   ::.|.|| :.|..|
Human   125 NLQPQGDEDPGKFKEAELKMRKQFGMPEG--EKLVNYYSCSYWKGRVP---RQGWLYLTVNHLCF 184

  Fly   637 GSTTEDRKKQDETCKHYYETTMSEWLAVDAIVQQREKEKTARAVAKLSSGSNSGNDRTVRAADLE 701
            .|....::          .:.:.:|:.:..:      ||.|..:.          ..::|.    
Human   185 YSFLLGKE----------VSLVVQWVDITRL------EKNATLLF----------PESIRV---- 219

  Fly   702 AGGDLENEVFEDISDISDPGDLEFDEQQQQQQQQAECAV-----SGNHLTVKPIPRAMKTSTDSG 761
              ...:.|:|..:.       |...|..:..:|.|..|:     |...|..|.:||.::      
Human   220 --DTRDQELFFSMF-------LNIGETFKLMEQLANLAMRQLLDSEGFLEDKALPRPIR------ 269

  Fly   762 HVDESFNELDEPDEEDNKQKQQQDEKISESESKLPDYR-KLEEQINQEPSCSASTASSYETVGPG 825
                       |....:..|:..|.: :::|.....:| ..:|:::...||:..|..:...: ||
Human   270 -----------PHRNISALKRDLDAR-AKNECYRATFRLPRDERLDGHTSCTLWTPFNKLHI-PG 321

  Fly   826 EVHQRPN--------------------------SDTRSVL-SPEYLSAD-------------DLQ 850
            ::....|                          :|:.||| ||..:|..             |..
Human   322 QMFISNNYICFASKEEDACHLIIPLREVTIVEKADSSSVLPSPLSISTKSKMTFLFANLKDRDFL 386

  Fly   851 LPDDEDAVRPPPPPAAAAVIITKASVDITNWERSPKAAEGDQM-----SPLE------------- 897
            :....|.::..|.....::...||||...:.|.||...||.:.     |||.             
Human   387 VQRISDFLQKTPSKQPGSIGSRKASVVDPSTESSPAPQEGSEQPASPASPLSSRQSFCAQEAPTA 451

  Fly   898 --------------EQAGESG-----------------GAGVNMDALQQPKSACAS--PASSNGG 929
                          |..|..|                 |.||.|....:.::....  |.|..|.
Human   452 SQGLLKLFQKNSPMEDLGAKGAKEKMKEESWHIHFFEYGRGVCMYRTAKTRALVLKGIPESLRGE 516

  Fly   930 V----------------YSSELLE----QFGLNLHRIEKDVQRCDRNYWYFANE-NLDKLRNVIS 973
            :                |.:||:|    ::.|....||:|:.|....:..|.|| .:..||.|::
Human   517 LWLLFSGAWNEMVTHPGYYAELVEKSTGKYSLATEEIERDLHRSMPEHPAFQNELGIAALRRVLT 581

  Fly   974 TYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKLMERMIENFPS----GGAMDMH-FANM 1033
            .|.:.:..:||.|.| ::|..:|:::..|..::.....|.|||:.::.:    |..:|.. |..:
Human   582 AYAFRNPTIGYCQAM-NIVTSVLLLYGSEEEAFWLLVALCERMLPDYYNTRVVGALVDQGIFEEL 645

  Fly  1034 -RSLIQILDSEMYDL--MDSNGDYTHFYFCYRWFL------LDFKRELVYDDVFATWEVIWAAKH 1089
             |..:..|..:|.||  :.|        ....|||      :.|:..:|..|.| .:|.|     
Human   646 TRDFLPQLSEKMQDLGVISS--------ISLSWFLTLFLSVMPFESAVVIVDCF-FYEGI----- 696

  Fly  1090 IASGHFVLFLALALLETYRDIILSNSMD---FTDVIKFFNEMAERHNAQSVLQLARSLV 1145
                ..:|.:|||:|:...:.:|..|.:   .|.:.::.:.:..:.:....:...|:|:
Human   697 ----KVILQVALAVLDANMEQLLGCSDEGEAMTMLGRYLDNVVNKQSVSPPIPHLRALL 751

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tbcNP_001285494.1 RUN 45..218 CDD:280855
PH_RUTBC 292..466 CDD:275431
TBC 923..1087 CDD:214540 48/198 (24%)
TBC1D9BNP_942568.2 PH-GRAM1_TCB1D9_TCB1D9B 153..251 CDD:275420 24/141 (17%)
PH-GRAM2_TCB1D9_TCB1D9B 299..394 CDD:270161 16/95 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 397..443 13/45 (29%)
TBC 505..715 CDD:214540 53/228 (23%)
EFh <855..906 CDD:298682
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 974..999
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1069..1093
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1128..1157
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5210
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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