Protein Alignment tbc and Rabgap1

DIOPT Version :9

• Sequence 1: NP_001285494.1
• Gene: tbc / 318059
• FlyBaseID: FBgn0052506
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: NP_001349885.1
• Gene: Rabgap1 / 227800
• MGIID: 2385139
• Length: 1064
• Species: Mus musculus
• Alignment Length: 536
• Identity: 118/536 - (22%)
• Similarity: 207/536 - (38%)
• Gaps: 126/536 - (23%)

  Fly   668 VQQREKEKTA--RAVAKLSSGSNSGNDRTVRAADLEAGGDLENEVFEDISDISDPGDLEFDEQQQ 730
            |||...::.|  |....|.|......:..:...|||:.|...:.....|:...:|....|....:
Mouse   328 VQQTANKELAIERCFGLLLSPGKDVRNSDMHLLDLESMGKSSDGKSYVITGSWNPKSPHFQVVNE 392

  Fly   731 QQQQQAECAVSGNHLTVKPIPRAMKTSTDSGHVDESFNELDEPDE---EDNKQKQQQDEKI---- 788
            :              |.|.....|.|:     ||....|:.||..   |...:....:|::
Mouse   393 E--------------TPKDKVLFMTTA-----VDLVITEVQEPVRFLLETKVRVCSPNERLFWPF 438

  Fly   789 SESESKLPDYRKLEEQINQEPSCSASTASSYETV---GPGEVHQRPNSDTRSVLSPEYLSADDLQ 850
            |:..:....:.||::...:|...:|.|.  ||.|   ...|..:|..:.:.||..|:..|...:
Mouse   439 SKRSTTENFFLKLKQIKQKEKKNNADTL--YEVVCLESESERERRKTTASPSVRLPQSGSQSSM- 500

  Fly   851 LP----DDEDAVRPPP---------PPAAAAVIITKASVDITNWERS----PKAAEGDQMSPLEE 898
            :|    |||:.....|         ...|..::.|...: ::.|..:    ||     |:|.|..
Mouse   501 IPSPPEDDEEEDNDEPLLSGFGDVSKECAEKILETWGEL-LSKWHLNLSVRPK-----QLSSLVR 559

  Fly   899 QAGESGGAGVNMDALQQPKSACASPASSNGGVY--------SSELLEQFGLNLHR-------IEK 948
                   :||              |.:..|.|:        :..|:|::.:.:.:       |.:
Mouse   560 -------SGV--------------PEALRGEVWQLLAGCHNNDHLVEKYRILITKESPQDSAITR 603

  Fly   949 DVQRCDRNYWYF---ANENLDKLRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFC 1010
            |:.|....:.||   ..:..|.|..:...|.....::||.||...|.|.||:...:|. ::|...
Mouse   604 DINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQGQSFLAAVLLLHMPEEQ-AFSVLV 667

  Fly  1011 KLM------ERMIENFPSGGAMDMH--FANMRSLIQILDSEMYD-LMDSNGDYTHFYFCYRWFLL 1066
            |:|      |...:||.     |:|  |..:..|:|....::|: .:|.:.: .|.| ..:|||.
Mouse   668 KIMFDYGLRELFKQNFE-----DLHCKFYQLERLMQEYIPDLYNHFLDISLE-AHMY-ASQWFLT 725

  Fly  1067 DFKRELVYDDVFATWEVIWAAKHIASGHFVLF-LALALLETYRDIILSNSMDFTDVIKFFN-EMA 1129
            .|..:.....||...:::     :..|..|:| :||.||:|.:|.:|..  ||...:|||. ::.
Mouse   726 LFTAKFPLYMVFHIIDLL-----LCEGISVIFNVALGLLKTSKDDLLLT--DFEGALKFFRVQLP 783

  Fly  1130 ERH----NAQSVLQLA 1141
            :|:    ||:.:::||
Mouse   784 KRYRSEENAKRLMELA 799

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_001285494.1	RUN	45..218	CDD:280855
		PH_RUTBC	292..466	CDD:275431
		TBC	923..1087	CDD:214540	43/190 (23%)
Rabgap1	NP_001349885.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..101
		PTB_Rab6GAP	140..268	CDD:269922
		DUF3694	302..432	CDD:315198	24/122 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	478..520		10/42 (24%)
		TBC	558..767	CDD:214540	54/242 (22%)
		ERM	789..1013	CDD:330563	4/11 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900