DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tbc and Tbc1d12

DIOPT Version :9

Sequence 1:	NP_001285494.1	Gene:	tbc / 318059	FlyBaseID:	FBgn0052506	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_666064.3	Gene:	Tbc1d12 / 209478	MGIID:	2384803	Length:	698	Species:	Mus musculus

Alignment Length:	406	Identity:	74/406 - (18%)
Similarity:	144/406 - (35%)	Gaps:	105/406 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   775 EEDNKQKQQQDEKISES---ESKLPDYRK--LEEQINQEPSCSASTASSYETVGPGEVHQRPNSD 834
            ||..:.:|:.||.::|:   |.|....||  ::|:..||.|.:::.......:.|.....|....
Mouse   335 EEALRHRQEYDEMVAEAKKREIKEAHKRKRIMKERFKQEESIASAMVIWINEILPNWEVMRSTRR 399

  Fly   835 TRSV----LSPEYLS-------ADDLQLPDDEDAVRPPPPPAAAAVIITKASVDITNWERSPKAA 888
            .|.:    |.|....       .::|.:           .|....:.:::|.....::..|....
Mouse   400 VRELWWQGLPPSVRGKVWSLAVGNELNI-----------TPELYEIFLSRAKERWKSFSESSSEN 453

  Fly   889 EGDQMSPLEEQAGESGGAGVNMDALQQPKSACASPASSNGGVYSSELLEQFGLNLHRIEKDVQRC 953
            :.:.:|..:.:|                                         :|..|:.|:.|.
Mouse   454 DTEGLSVADREA-----------------------------------------SLELIKLDISRT 477

  Fly   954 DRNYWYF--ANENLDKLRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKLMER- 1015
            ..:.:.|  .....|.|.:::..|.....||||:||| ..:|.:|::..:|:.::..|..|:.:
Mouse   478 FPSLYIFQKGGPYHDVLHSILGAYTCYRPDVGYVQGM-SFIAAVLILNLEEADAFIAFANLLNKP 541

  Fly  1016 ------------MIENFPSGGAMDMHF-ANMRSLIQILDSEMYDLMDSNGDYTHFYFCYRWFLLD 1067
                        |::.|   ...::.| .|:..|  .|..:.|:|       |...:...|....
Mouse   542 CQLAFFRVDHSMMLKYF---ATFEVFFEENLSKL--FLHFKSYNL-------TPDIYLIDWIFTL 594

  Fly  1068 FKRELVYDDVFATWEVIWAAKHIASGHFVLF-LALALLETYRDIILSNSMDFTDVIKFFNEMAER 1131
            :.:.|..|.....|:|.     ...|...|| ..|.:|..|.||:|  .|||..:.:|..::.|.
Mouse   595 YSKSLPLDLACRVWDVF-----CRDGEEFLFRTGLGILRLYEDILL--QMDFIHIAQFLTKLPED 652

  Fly  1132 HNAQSVLQLARSLVLQ 1147
            ..::.:.....::.:|
Mouse   653 ITSEKLFSCIAAIQMQ 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_001285494.1	RUN	45..218	CDD:280855
		PH_RUTBC	292..466	CDD:275431
		TBC	923..1087	CDD:214540	34/179 (19%)
Tbc1d12	NP_666064.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..59
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	93..123
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	158..236
		COG5210	304..639	CDD:227535	69/375 (18%)
		RabGAP-TBC	468..635	CDD:278964	41/184 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900