DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tbc and Tbc1d16

DIOPT Version :9

Sequence 1:	NP_001285494.1	Gene:	tbc / 318059	FlyBaseID:	FBgn0052506	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	XP_006532756.1	Gene:	Tbc1d16 / 207592	MGIID:	2652878	Length:	782	Species:	Mus musculus

Alignment Length:	1045	Identity:	183/1045 - (17%)
Similarity:	289/1045 - (27%)	Gaps:	489/1045 - (46%)

- Green bases have known domain annotations that are detailed below.

  Fly   255 KRSLNTSSD-----EAGTGSFKSIASASVAKDYVESLHQNAKATLLYGKNNVQV-LPKDVAEP-- 311
            :|:.:.:||     ..|:|...|:....|                :|.||||.| .|:.:..|
Mouse     8 RRASSKASDLLTLTTGGSGGSLSVLDGEV----------------IYSKNNVCVHAPEGLQGPGE 56

  Fly   312 -MPGYLSLHQHIQ-----TLTIKWTPNQLMNGYTEAEEA-------------------------- 344
             .||||.|:....     ||.:.|.||..:.  .:.|||
Mouse    57 HHPGYLCLYMEKDELLGATLILAWVPNSRIQ--RQDEEALRYITPESSPVRKAPRPRRRRTTSLG 119

  Fly   345 ------------------EDIDKDAFWAYALNINVDEIVYVHCHQSRGE---------------- 375
                              |||       ..:..|..:..::......||
Mouse   120 ALYQPSPTEPRPPLIPKDEDI-------LVVVQNTQDTAHISPTDEDGEKLAQGPEVDGALSTSQ 177

  Fly   376 ----DSGGTVILVGQDGVQ--RPPIHFPEGGHMQQFLSCLETGLLPHGQLDPPLWSQRGIGKMFL 434
                |||....:..|||.:  |.|  .||....:..|.....|:......|..       ...|.
Mouse   178 PVHSDSGILSTVSSQDGTEDGREP--RPEAVEEEGSLELSADGVSRDSSFDSD-------SDAFS 233

  Fly   435 WPRSMRRRILPSVMESVDETPIDYVFRIVSKSRHEEFAATHSILDFVRSTPRRAQLSSCSTTGSS 499
            .|..:              :||.......:.|...|...:...::....||:    ...|:..||
Mouse   234 SPFCL--------------SPISAALAEGNSSAFLESEGSRQAINCWVGTPK----EGISSPSSS 280

  Fly   500 DCSNKSLSIDQFPMESPLILQQQQQQQQQLLQAQSTSIEMVCSTMRRQI---------------- 548
            |.:.:      || :|..:||..:..:.|    :..::|.:|...|..:
Mouse   281 DANLR------FP-DSNGLLQTPRWDEPQ----RGCALEQICGVFRVDLGHMRSLRLFFSDEACT 334

  Fly   549 -------------------------ISRAFYGWLAYCRHLSTVRTHLSGLVHGRITPEMKA---- 584
                                     :|..|..| .:|     ..|||.   ..::|.|...
Mouse   335 SGQLVVASRESQYKIFHFHHGGLDKLSEVFQQW-KFC-----TETHLR---DQQVTDERTCMQFS 390

  Fly   585 ------------DEEGLTK----ERW-QLLNVNGVLENATEFYRLVYFGGVQPELRQEVWPYLLG 632
                        .||.|.:    ..| ..||..|.:|...:..:.::|||:...:|.||||:||.
Mouse   391 IRRPKLPSSEIHPEESLYRRLDVSAWLNHLNDLGQVEEEYKLRQAIFFGGIDVSIRGEVWPFLLH 455

  Fly   633 HYAFGSTTEDRKKQDETCKHYYETTMSEWLAVDAIVQQREKEKTARAVAKLSSGSNSGNDRTVRA 697
            :|:..||:|:|                     :|:..|:.||..|....:||
Mouse   456 YYSHESTSEER---------------------EALRSQKRKEYAAIQQKRLS------------- 486

  Fly   698 ADLEAGGDLENEVFEDISDISDPGDLEFDEQQQQQQQQAECAVSGNHLTVKPIPRAMKTSTDSGH 762

Mouse   487 ----------------------------------------------------------------- 486

  Fly   763 VDESFNELDEPDEEDNKQKQQQDEKISESESKLPDYRKLEEQINQEPSCSASTASSYETVGPGEV 827

Mouse   487 ----------------------------------------------------------------- 486

  Fly   828 HQRPNSDTRSVLSPEYLSADDLQLPDDEDAVRPPPPPAAAAVIITKASVDITNWERSPKAAEGDQ 892

Mouse   487 ----------------------------------------------------------------- 486

  Fly   893 MSPLEEQAGESGGAGVNMDALQQPKSACASPASSNGGVYSSELLEQFGLNLH-RIEKDVQRCDRN 956
            |:|.|::|                                      |..|:. .::|||.|.|||
Mouse   487 MTPEEQRA--------------------------------------FWRNVQFTVDKDVVRTDRN 513

  Fly   957 YWYFA---NENLDKLRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKLMERMI- 1017
            ..:|.   |.|::.:|.::..|...:..:||.|||.|||||:|....|||.::.||..||:..|
Mouse   514 NQFFRGEDNPNVESMRRILLNYAVYNPAIGYSQGMSDLVAPILAEVLDESDTFWCFVGLMQNTIF 578

  Fly  1018 ENFPSGGAMDMHFANMRSLIQILDSEMYDLMDSNG-DYTHFYFCYRWFLLDFKRELVYDDVFATW 1081
            .:.|....|:.....:|.|:::.....|..:.|.| |.....||:||.||.||||....:....|
Mouse   579 VSSPRDEDMERQLLYLRELLRLTHQRFYQHLVSLGEDGLQMLFCHRWLLLCFKREFPEAEALRIW 643

  Fly  1082 EVIWAAKHIASGHFVLFLALALLETYRDIILSNSMDFTDVIKFFNEMAERHNAQSVLQLARSLVL 1146
            |..||  |..:.:|.||:.:|::..|.|.::...:....::..|..:|...|.:.||:.||||:.
Mouse   644 EACWA--HYQTDYFHLFICVAIVAIYGDDVIEQQLATDQMLLHFGNLAMHMNGELVLRKARSLLY 706

  Fly  1147 QLQMI 1151
            |.:::
Mouse   707 QFRLL 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_001285494.1	RUN	45..218	CDD:280855
		PH_RUTBC	292..466	CDD:275431	44/248 (18%)
		TBC	923..1087	CDD:214540	54/169 (32%)
Tbc1d16	XP_006532756.1	TBC	439..667	CDD:214540	85/496 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900