DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tbc and tbc-19

DIOPT Version :9

Sequence 1:	NP_001285494.1	Gene:	tbc / 318059	FlyBaseID:	FBgn0052506	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_510336.3	Gene:	tbc-19 / 181511	WormBaseID:	WBGene00007849	Length:	1333	Species:	Caenorhabditis elegans

Alignment Length:	841	Identity:	162/841 - (19%)
Similarity:	277/841 - (32%)	Gaps:	265/841 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   430 GKMFLWPRSMRRRILPSVMESVDETPIDYVFRIVSKSRHEEFAATHSILDFVRSTPRRAQLSSCS 494
            |.:.||  ..|||...::.|..:|        :|......||.                  |...
Worm    25 GALALW--RPRRRFYFAIDEITEE--------LVYYKTEGEFT------------------SHRE 61

  Fly   495 TTGSSDCSNKSLSIDQFPMESPLILQQQQQQQQQLLQAQSTSIEMVCSTMRRQIISRAFYGWL-A 558
            ..||...||..:::|:   .:.||.         :|.....|||.....      ..:...|| .
Worm    62 PVGSFPISNSVITLDE---NNHLIF---------ILHVSGRSIEFEADN------EESCRAWLHT 108

  Fly   559 YC-RHLSTVRTHLSGLVHGRITPEMKA----DEEGLTKERWQLLNVNGVLENATEFYRLV----- 613
            :| |:....||....:.|.:|   .||    |:|..|....|.:...   :::.....||
Worm   109 FCNRYSEAERTKYQMMTHRKI---KKASSLPDQESTTAATDQHIPFR---KHSVPAQNLVTTRNF 167

  Fly   614 ------YFGGVQPELRQEVW--PYLLGH--YAFGSTTE-------DRKKQDETCKHYYETTMSEW 661
                  ...|..|:...:.|  .:|...  :.|.|.|:       ::.|.| ||.. .|...||.
Worm   168 IMPPPDIAEGYLPDEEMDDWVTQWLTNEKFHNFPSCTDMTTPTSTNQSKVD-TCSE-SERAESEE 230

  Fly   662 LAVDAIVQQREKEKTARAVAKLS------------SGSNSGNDRTVRAADLEAGGDLENEVFEDI 714
            |.:...:...:|:|......:::            :.|.:|.||...:|..:.   |.:|:.
Worm   231 LDLLREITNNQKKKIEDMKHEMNAMTLHIDQMRKRADSTNGTDRDTLSAQNKF---LNSEIL--- 289

  Fly   715 SDISDPGDLEFDEQQQQQQQQAECAVSGNHLTVKPIPRAMKTSTDSGHVDESFNELDEPDEEDNK 779
                              :..|:|.:    ||::          .||                |:
Worm   290 ------------------RMSAKCEI----LTMQ----------SSG----------------NR 306

  Fly   780 QKQQQDEKISESESKLP-DYRKLEEQINQEP--SCSASTASSYETVGPGEVHQR----------- 830
            :..:::::::|....|. ||....:...:.|  ..:|....|.:.:| ||.|:.
Worm   307 KSHRENKRLTEELQLLRCDYVYAIQSTIRIPLHDNTAMDVMSVKLLG-GETHKSRLIQLMAEARQ 370

  Fly   831 --PNSDT-RSVLSPEYLSADDLQLPDDEDAVRPPPPPAAAAVIITK-----------ASVDITNW 881
              |:..| :|:|...|:.:...::...|:       |.|...:.||           ||....||
Worm   371 HDPSLPTLQSLLQGIYVDSFGFRISFKEE-------PNALHYMATKLNHFYANRSKSASEHKYNW 428

  Fly   882 ERSPKAAEGDQMSPLEEQAGESGGAGVNMDALQQPKSACAS--PASSNGGVYS-------SELLE 937
            :|.           |||..        .:|...:.|..|..  |.|....|:.       .:|..
Worm   429 KRF-----------LEEND--------FIDLTPETKIMCRKGIPNSLRATVWKILINQQVEDLKN 474

  Fly   938 QFGLNLHR---------------------IEKDVQRCDRNYWYFANEN---LDKLRNVISTYVWE 978
            .:|...:|                     |..|:.|...|..:|.:.|   :.:|..|:..:...
Worm   475 VYGKYYYRNLCNIQGGEDEKTYSDVHQKQINLDLLRTMPNNVHFMSANSKGVTQLLQVLHAFCLH 539

  Fly   979 HLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKLMERMIEN--FPS---GGAMDMHFANMRSLIQ 1038
            :..:||.|||..|.|..|:....|. ::.....:.||..:.  |.|   |...|...  ::.|::
Worm   540 NSQIGYCQGMNFLAATALLFVGPED-AFWFLIAVTERYFDKTYFDSNLTGAQADQEV--LKGLLE 601

  Fly  1039 ILDSEMYDLMDSNGDYTHFYFCYRWFLLDFKRELVYDDV-FATWEVIWAAKHIASGHFVLF-LAL 1101
            :...::...:.|. |.....|...||:     .|.:|.| |.|...||.. .:..|..||| .|:
Worm   602 VQHPKIMKHLKSL-DIDVASFTLNWFI-----SLFFDAVPFNTLLRIWDC-FLLEGPKVLFRFAI 659

  Fly  1102 ALLETYRDIILSNSMDFTDVIKF--------FNEMAERHNAQSVLQLARSLVL---QLQMI 1151
            .|:..:.:.|:|.. |...:::.        |:|.|..:.|..:..|...:.|   |||.:
Worm   660 VLIGKHEEEIISRG-DAIGIMRVSKAATKLAFDEEAIVNMAFRIPNLPTRIELKNMQLQYV 719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_001285494.1	RUN	45..218	CDD:280855
		PH_RUTBC	292..466	CDD:275431	9/35 (26%)
		TBC	923..1087	CDD:214540	42/200 (21%)
tbc-19	NP_510336.3	PH-like	13..112	CDD:302622	26/132 (20%)
		PH	16..110	CDD:278594	25/130 (19%)
		TBC	448..670	CDD:214540	49/231 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810