DRSC/TRiP Functional Genomics Resources

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Protein Alignment tbc and tbc-16

DIOPT Version :10

Sequence 1:NP_608395.6 Gene:tbc / 318059 FlyBaseID:FBgn0052506 Length:1155 Species:Drosophila melanogaster
Sequence 2:NP_508988.3 Gene:tbc-16 / 180856 WormBaseID:WBGene00018639 Length:725 Species:Caenorhabditis elegans


Alignment Length:985 Identity:180/985 - (18%)
Similarity:304/985 - (30%) Gaps:446/985 - (45%)


- Green bases have known domain annotations that are detailed below.


  Fly   283 VESLHQNAKATLLYGKNNVQVLPKDV-----AEPMPGYLSLHQHIQ-----TLTIKWTPNQLM-- 335
            |.|........::|.||||.|...|.     ....||||::|....     ||.::|.||..:  
 Worm    21 VNSFFLGRDGDVVYSKNNVCVHETDAKAGEDEAHCPGYLTVHCQCDESMGLTLILQWLPNLTLQK 85

  Fly   336 ------------------NGYT-EAEEAEDI------DKDAFWAYALNINVDEIVYVHCHQSRGE 375
                              ||.. .|:.|:::      |:::  :.:|:|.::|     |      
 Worm    86 NPQSIRSVSPRGKQNRDENGQAMPAKPADEVKVSLLSDEES--SVSLDIQIEE-----C------ 137

  Fly   376 DSGGTVILVGQDGVQRPPIHFPEGGHMQQFLSCLETGLLPHGQLDPPLWSQRGIGKMFLWPRSMR 440
               ||.:.|.|  |:||                  |.|:|:||.:...::. .:|          
 Worm   138 ---GTAVPVKQ--VKRP------------------TTLVPYGQQEDHSFND-ALG---------- 168

  Fly   441 RRILPSVMESVDETPIDYVFRIV--SKSRHEEFAATHSILDFVRSTPRRAQLS----SCSTTGSS 499
               :||: ..:..|||.:....:  ..::.|....:.|.|    ||....::|    |.|..|..
 Worm   169 ---VPSI-NVIPHTPIKHENNEIRTENAKDESDKMSQSSL----STSCADEMSDKELSSSEDGDD 225

  Fly   500 DCSNKSLSI----------------DQFPMESPLIL------QQQQQQQQQLLQAQSTSIEMVCS 542
            ||......:                :||.:|..|:|      ..::|.:.:...|.:||:..|..
 Worm   226 DCEKPDPGVGLEKILESTQMFDKTPEQFALEHDLMLTDTKSNDSEEQSRGRKKAAGTTSLFSVNL 290

  Fly   543 TMRRQIISRAFY-------GWLAYC---RHLSTVRTHLSGL------------VHGR-------- 577
            ...|.:  |.||       |.|...   .|...:..|..||            :..|        
 Worm   291 GKMRSM--RVFYSNTECTSGQLVIATLDSHYKILHFHHGGLDKLAYIFEQWSSIKARSVQEGSPS 353

  Fly   578 -------------ITPEMKADEEGL----TKERWQLL-NVNGVLENATEFYRLVYFGGVQPELRQ 624
                         :|...|..||||    |...|:.. |.:||:.::....:.::|..:..|:|:
 Worm   354 AIADKQLIICQPAVTKVEKDPEEGLFEKITLNTWRSYENKSGVIIDSGTVRKHIFFASMDVEMRE 418

  Fly   625 EVWPYLLGHYAFGSTTEDRKKQDETCKHYYETTMSEWLAVDAIVQQREKEKTARAVAKLSSGSNS 689
            :|||:||..|.:.|:.:.|:                                             
 Worm   419 KVWPFLLRVYPWESSADQRE--------------------------------------------- 438

  Fly   690 GNDRTVRAADLEAGGDLENEVFEDISDISDPGDLEFDEQQQQQQQQAECAVSGNHLTVKPIPRAM 754
                           :::|::|           ||:                             
 Worm   439 ---------------NIKNDLF-----------LEY----------------------------- 448

  Fly   755 KTSTDSGHVDESFNELDEPDEEDNKQKQQQDEKISESESKLPDYRKLEEQINQEPSCSASTASSY 819
                                  .|.:|::              ||..|                 
 Worm   449 ----------------------QNIRKRR--------------YRVTE----------------- 460

  Fly   820 ETVGPGEVHQRPNSDTRSVLSPEYLSADDLQLPDDEDAVRPPPPPAAAAVIITKASVDITNWERS 884
                        |:..|.:                                    |::       
 Worm   461 ------------NAQARWI------------------------------------SIE------- 470

  Fly   885 PKAAEGDQMSPLEEQAGESGGAGVNMDALQQPKSACASPASSNGGVYSSELLEQFGLNLHRIEKD 949
                                                                       :.|.||
 Worm   471 -----------------------------------------------------------NSIVKD 476

  Fly   950 VQRCDRNYWYFA---NENLDKLRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCK 1011
            |.|.||...:||   |.|.:.::|::..|...:.|:.|:|||.||:||||....||..||.||..
 Worm   477 VVRTDRKNPFFAGDNNPNSEIMKNILLNYAVMYPDINYIQGMSDLLAPLLSTLKDEVDSYFCFKN 541

  Fly  1012 LMERMI-ENFPSG--GAMDMHFANMRSLIQILDSEMYD-LMDSNGDYTHFYFCYRWFLLDFKREL 1072
            .|::.: .:.|.|  ..|:.:...:|:::::...:.|: |.....|.....|.:||.||.||||.
 Worm   542 FMQQTVFSSTPQGNENLMETNLTYLRNMLRMFVPDFYEHLEKQRPDAMQLMFVHRWILLCFKREF 606

  Fly  1073 VYDDVFATWEVIWAAKHIASGHFVLFLALALLETYRDIILSNSMDFTDVIKFFNEMAERHNAQSV 1137
            ..:.....||..||  |..:.:|.||:.:|::..|...:|:..:...:::.||..:|...:|..|
 Worm   607 PENYALHIWECCWA--HYRTNYFHLFVCVAIVSIYGKDVLTQDLPHDEILLFFASLANHMDATLV 669

  Fly  1138 LQLARSLVLQ 1147
            ||.||.|:.:
 Worm   670 LQKARGLLFE 679

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tbcNP_608395.6 RUN_SGSM1_like 21..214 CDD:439049
PH_RUTBC 292..466 CDD:275431 44/212 (21%)
TBC 923..1087 CDD:214540 50/170 (29%)
tbc-16NP_508988.3 PH_RBD 32..>112 CDD:432305 20/79 (25%)
TBC 415..644 CDD:214540 79/497 (16%)
Blue background indicates that the domain is not in the aligned region.

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