Protein Alignment tbc and tbc-8

DIOPT Version :10

• Sequence 1: NP_608395.6
• Gene: tbc / 318059
• FlyBaseID: FBgn0052506
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: NP_001255072.1
• Gene: tbc-8 / 176454
• WormBaseID: WBGene00008018
• Length: 913
• Species: Caenorhabditis elegans
• Alignment Length: 1177
• Identity: 343/1177 - (29%)
• Similarity: 510/1177 - (43%)
• Gaps: 374/1177 - (31%)

  Fly     9 SDYKERLIASVKKEVKQLMEEAVTKKYVHEESSSVTSLCGAVEACLSQGLRRRALGLFKTSSTTA 73
            :.::|.|:..:|.|:|.:|.|...|||::..|..|||||.||:||:..|||||.|.||.:.|:.:
 Worm    78 TQHREVLLTKLKIEIKNIMAEHGAKKYLNLNSPYVTSLCIAVDACIMDGLRRRLLTLFNSPSSMS 142

  Fly    74 LLHKIAKSCPEAEHISKLVQEIEASDPSKRSSSSSDSFQRPPMLKKSSSNSMSTGTNAAASTSSA 138
            ||..||||...|:.:....:|||
 Worm   143 LLQIIAKSNGPAQQVLDQTREIE------------------------------------------ 165

  Fly   139 SASISVSASTSSMSLASMKYLWIRLALYEKRLTKIIEYLVSNAS--SFYDRDSLVADSDYGSILS 201
                  ...||::   .:..:|||.|||.|.|:.||.:.:.:.|  .:||..:|:.|...|.:::
 Worm   166 ------ELRTSAI---PVHLIWIREALYLKSLSTIINHFIDSKSVRRYYDNSALLLDPVKGRLVA 221

  Fly   202 SLLVGPCALEFTRAKTADHYWTDPHADELVQRHRISSCRRSSSTC-SRPAIINFKRSLNTSSDEA 265
            :|::.||.:.:.|  .::....:..|:|||:    .:.|.|:||. |||.:             :
 Worm   222 TLMMAPCMVTYRR--MSNRIEQEATAEELVE----GATRGSTSTVPSRPPL-------------S 267

  Fly   266 GTGSFKSIASA-----SVAKDYVESLHQNAKATLLYGKNNVQVL--PKDVAEPMPGYLSLHQHIQ 323
            .|....|||::     ||::|||.|||.:.|:|||||||||.|.  ..|.|:   ||:||.:...
 Worm   268 ITRQVSSIAASVERNGSVSRDYVFSLHHSCKSTLLYGKNNVCVAMNGSDFAK---GYMSLQKFYD 329

  Fly   324 -TLTIKWTPNQLM-------NGYTEAEEAEDIDKDAFWAYALNINVDEIVYVHCHQSRGEDSGGT 380
             .|::||.|||||       :|::...|..:|     |...:||.:.:|:|:|.|| :.|.|...
 Worm   330 GNLSLKWVPNQLMHASSQPSSGHSNNGEFTNI-----WKNTINIEMQDIIYIHLHQ-KDEISPTC 388

  Fly   381 VILVGQDGVQRPPIHFPEGGHMQQFLSCLETGLLPHGQLDPPLWSQRGIGKMFLWPRSMRRRILP 445
            :..|..:|||..|...|.|.|...|||.|||||.|..:||||||    :|       :.:.:|||
 Worm   389 LTFVNCEGVQSAPFQLPAGQHSIAFLSSLETGLAPLLRLDPPLW----VG-------TTKEKILP 442

  Fly   446 SVMES----VDETPIDYVFRIVSKSRHEEFAATHSILDFVRSTPRRAQLSSCSTTGSSDCSNKSL 506
            .:.:.    .:...:|||||:|..|.             |...|...:.....|:.|....:..:
 Worm   443 RLRKRSTAVANPAMLDYVFRLVRTSG-------------VEPAPEDIEDPLAPTSHSPPIHDNCV 494

  Fly   507 SIDQFPMESPLILQQQQQQQQQLLQAQSTSIEMVCSTMRRQIISRAFYGWLAYCRHLSTVRTHLS 571
            |:.    .||.|:    .....::..|   |...|.:||.||::|||||||.|.|||.|:||||.
 Worm   495 SLP----NSPYIV----DNVDSIVNFQ---IGTACQSMRNQIMARAFYGWLTYVRHLRTIRTHLL 548

  Fly   572 GLVHGRITPEMKADE--EGLTKERWQLLNVNGVLENATEFYRLVYFGGVQ----PELRQEVWPYL 630
            .||.   |..:..|:  :.:.::.|:........||..||.:.||:.|::    .|:|:..||||
 Worm   549 HLVD---TKTLICDDDCDPVDEKFWKQARAEPTEENEKEFLKRVYWRGIEGINTKEVRRMAWPYL 610

  Fly   631 LGHYAFGSTTEDRKKQDETCKHYYETTMSEWLAVDAIVQQREKEKTARAVAKLSSGSNSGNDRTV 695
            ||.:.:..:.|.|.:|..:   .|...:.||..::|.|::|::|                   ..
 Worm   611 LGLFEWNESPESRLEQFTS---QYWQDIEEWRVLEAEVRRRDEE-------------------AF 653

  Fly   696 RAADLEAGGDLENEVFEDISDISDPGDLEFDEQQQQQQQQAECAVSGNHLTVKPIPRAMKTSTDS 760
            |||                                                     ||.|.:  |
 Worm   654 RAA-----------------------------------------------------RARKAA--S 663

  Fly   761 GHVDESFNELDEPDEEDNKQKQQQDEKISESESKLPDYRKLEEQINQEPSCSASTASSYETVGPG 825
            ...:||.:..::|:                                 ||:||
 Worm   664 PVREESCDVFEDPN---------------------------------EPTCS------------- 682

  Fly   826 EVHQRPNSDTRSVLSPEYLSADDLQLPDDEDAVRPPPPPAAAAVIITKASVDITNWERSPKAAEG 890
            :.:.|.|
 Worm   683 QHYDREN---------------------------------------------------------- 689

  Fly   891 DQMSPLEEQAGESGGAGVNMDALQQPKSACASPASSNGGVYSSELLEQFGLNLHRIEKDVQRCDR 955
                                                        |:..|..|||||:|||:||||
 Worm   690 --------------------------------------------LITLFRANLHRIDKDVERCDR 710

  Fly   956 NYWYFAN-ENLDKLRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKLMERMIEN 1019
            |..:|:| :||:.||.|:.|||..:|:.||.||||||:|||||.|:||:|:..||..||.|....
 Worm   711 NLMFFSNKDNLESLRRVMYTYVRRNLEEGYTQGMCDLLAPLLVTFEDEALTLECFSLLMLRQRGK 775

  Fly  1020 FPSGGAMDMHFANMRSLIQILDSEMYDLMDSNGDYTH-FYFCYRWFLLDFKRELVYDDVFATWEV 1083
            ||....|.....|:|||||::|.::|.|: |:.||.. ..|.:|||||||||||.|:..:..|||
 Worm   776 FPQRPGMSKCLLNLRSLIQVVDPQIYALI-SDIDYAQALSFAFRWFLLDFKRELSYECTYKVWEV 839

  Fly  1084 IWAAKHI-ASGHFVLFLALALLETYRDIILSNSMDFTDVIKFFNEMAERHNAQSVLQLARSLVLQ 1147
            ||||:.: .:..|.:|..||.:..|.|::::|:.|:||:|||||||||||:...:|..||:.|..
 Worm   840 IWAAQRLRITDDFAIFFGLATITNYHDVLITNNFDYTDMIKFFNEMAERHDCSRLLSSARTHVKC 904

  Fly  1148 LQMIIEN 1154
            ||.::::
 Worm   905 LQNLVQH 911

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_608395.6	RUN_SGSM1_like	21..214	CDD:439049	57/194 (29%)
		PH_RUTBC	292..466	CDD:275431	70/187 (37%)
		TBC	923..1087	CDD:214540	81/165 (49%)
tbc-8	NP_001255072.1	RUN	90..234	CDD:459241	57/194 (29%)
		PH_RUTBC	299..467	CDD:275431	70/187 (37%)
		TBC	670..869	CDD:214540	96/347 (28%)