DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tbc and tbc-2

DIOPT Version :9

Sequence 1:	NP_001285494.1	Gene:	tbc / 318059	FlyBaseID:	FBgn0052506	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_495156.1	Gene:	tbc-2 / 173986	WormBaseID:	WBGene00022880	Length:	908	Species:	Caenorhabditis elegans

Alignment Length:	1034	Identity:	191/1034 - (18%)
Similarity:	329/1034 - (31%)	Gaps:	372/1034 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   257 SLNTSSDEAGTGSFKSIASA-----SVAKDYVESLHQNAKATLLYGKNNVQVL-----PKDVAEP 311
            :|..|||:......|::.|.     ...|...:|   :...:.|.|:|:..||     |..|  |
Worm    93 ALECSSDKQRNEWMKALQSTRKRSWKATKSKSDS---SLDISSLTGRNSSSVLEECSSPSPV--P 152

  Fly   312 MPGYLSLHQHIQTLTIKWTPNQLMNGYTEAEEAEDIDKDAFWAYALNINVDEIVYVHCHQSRGED 376
            .|......:..|.||         ...|:||.:.|:...       :....|:|         ||
Worm   153 PPRSPKPKKRTQFLT---------EEETDAETSSDVPHS-------SEETAEVV---------ED 192

  Fly   377 SGGTVILVGQDGVQRPPIHFPEGGHMQQFLSCLETGLLPHGQLDPPLWSQRGIGKMFLWPRSMRR 441
            :..|.|              |..|      |..|..|.|:|||:               .||::
Worm   193 TDNTKI--------------PAEG------SATEWYLNPNGQLN---------------ERSLQ- 221

  Fly   442 RILPSVMESVD-------ETPIDYVFRIVSK-----SRHEEFAATHSILDFVRSTPRRAQLSSCS 494
              :|..:||.:       :..|:..||.:.:     ||..:..:...::.     .|:..:||..
Worm   222 --MPKTIESPETVLKRLADQSIEAPFRAIRRNLSTWSRSRQNTSDEPVVG-----SRKGTVSSVD 279

  Fly   495 TTGSS---DCSNKSLSIDQF--PMESPLILQQQQQQQQQLLQAQSTSIEMVCSTMRRQIISRAFY 554
            .|...   :.|:|..|:::.  .:.:.|:|.|:..:..|.::....:.|    .||..|:.
Worm   280 LTPEEKVIELSDKVSSLEEVVDSLRAALLLAQRNNEALQKIEDMGDNKE----EMREYILE---- 336

  Fly   555 GWLAYCRHLSTVRTHLSGLVHGRITPEMKADEEGLTKERWQLLNVNGVLENATEFYRLVYFGGVQ 619
                  :.......|:|..::.|...:       |..:..:|.:....|:.:.|.:|
Worm   337 ------KERQVTELHISNSMNARRVRD-------LEDQNVRLEDTINDLQQSVEAFR-------- 380

  Fly   620 PELRQEVWPYLLGHYAFGSTTEDRKKQDETCKHYYETTMSEWLAVDAIVQQREKEKTARAVAKLS 684
                                 |..:.::|                 .|::..|:|.....:..:|
Worm   381 ---------------------ESLRTKEE-----------------LILRMCEEENREDLLGSIS 407

  Fly   685 S-GSNSGNDRTVRAADLEAGGDLENEVF--------------EDISDISDPGDLEFDEQQQQQQQ 734
            . .||...|.....:|:|....:..:|.              |::.||.:..||....:.|.|..
Worm   408 ERSSNIPADANGLVSDVEVPEGILVDVSSVDCEEATRKVLDEENVRDIGELQDLVEGYRTQNQFL 472

  Fly   735 QAECA-----------------------------VSGNHLTVKPIPRAMKTSTDSGHVDES--FN 768
            .||..                             :...:|.|.   ...|:.|..|.:.|.  ..
Worm   473 NAEIVQLHAITQSLEDREKKLIRQNFDLEACYYQLKSRYLMVL---NHFKSPTKPGKIMEPGVLK 534

  Fly   769 ELDEPDEEDNKQKQQ---------QDEKISESESKLPDYRKLEEQINQEPSCSASTASSYETVGP 824
            ||.|......::.||         :.:..|||:..|                  .||:.|....
Worm   535 ELLEESARTPRESQQNLTDQLGFYKKDDFSESDDLL------------------DTATFYMKKA- 580

  Fly   825 GEVHQRPNSDTRSVLSPEYL----SADD-------------LQLPDDEDAVRPPPPPAAAAVIIT 872
            |:|.:.    |:...|.||:    |.|.             :..||.:..:|...|||....:
Worm   581 GDVVEA----TKLEQSEEYMKWLQSWDAFLVNNTVSRQTAIMSSPDLKTLIRTGVPPAYRGRV-- 639

  Fly   873 KASVDITNWERSPKAAEGDQMSPLEEQAGESGGAGVNMDALQQPKSACASPASSNGGVYSSELLE 937
             ..:.:|:|.:..:|..|:               |.....|::      :......|.|.: .::
Worm   640 -WKIIVTHWVKDKQAELGN---------------GYYQSMLRK------AGTKKQDGSYDA-AIK 681

  Fly   938 QFGLNLHRI--------EKDVQRCDRNYWYFANENLDKLRNVISTYVWEHLDVGYMQGMCDLVAP 994
            |..|:|.|.        |.|            :.|::|||||:..:.:.:..|||.||:..|.|.
Worm   682 QIDLDLARTLPTNKLFDEPD------------SANIEKLRNVLYAFRYHNSHVGYCQGLNRLAAI 734

  Fly   995 LLVIFDD-ESLSYSCFCKLMERMIENF-PSG-------GAM-------DMHFANMRSLIQILDSE 1043
            .|:..|: :|..:...|      :|:. |.|       ||:       |:....:..|...|.:.
Worm   735 ALLNLDEQDSFWFLVAC------VEHLQPEGYYTSSLIGAVADQKVLRDLVAEKLPKLAAHLRAL 793

  Fly  1044 MYDLMDSNGDYTHFYFCYRWFL---LDFKRELVYDDVFATWEVIWAAKHIASGHFVLF-LALALL 1104
            ..||.         .|...|||   :|.....:|..:|..:        :..|:.||| .||||.
Worm   794 EVDLS---------LFALSWFLTCFVDVLPHSIYLTIFDAF--------LYEGNKVLFRFALALF 841

  Fly  1105 ETYRDIIL----------------SNSMDFTDVIKF-FNEMAERHNAQSVLQLARSLVL 1146
            :.....:|                .:.:||..:.:. |||:  ....|..::..|.|.|
Worm   842 KICEPHVLQCKTIGTVHQCLSKAQEHIIDFKSLAQVAFNEL--NPFPQKTIETKRQLYL 898

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_001285494.1	RUN	45..218	CDD:280855
		PH_RUTBC	292..466	CDD:275431	39/190 (21%)
		TBC	923..1087	CDD:214540	42/190 (22%)
tbc-2	NP_495156.1	PH_TBC1D2A	20..119	CDD:269966	6/25 (24%)
		PH	20..111	CDD:278594	5/17 (29%)
		ATG16	235..400	CDD:285778	33/236 (14%)
		DUF1664	<289..368	CDD:285172	16/99 (16%)
		TBC	627..849	CDD:214540	60/281 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810