DRSC/TRiP Functional Genomics Resources

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Protein Alignment tbc and TBC1D21

DIOPT Version :10

Sequence 1:NP_608395.6 Gene:tbc / 318059 FlyBaseID:FBgn0052506 Length:1155 Species:Drosophila melanogaster
Sequence 2:XP_006720472.1 Gene:TBC1D21 / 161514 HGNCID:28536 Length:399 Species:Homo sapiens


Alignment Length:221 Identity:54/221 - (24%)
Similarity:93/221 - (42%) Gaps:47/221 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   935 LLEQFGLNLHR--------IEKDVQRC-DRNYWYFANENLDKLR---NVISTYVWEHLDVGYMQG 987
            |||    ||||        |.:|:|:. |::  ...|..:||.|   .::.:||. :....|.||
Human   107 LLE----NLHRNFTETRNNIARDIQKIYDKD--PLGNVLIDKKRLEKILLLSYVC-NTQAEYQQG 164

  Fly   988 MCDLVA--PLLVIFDDESL----------SYSCFCKLMERMIENFPSGGAMDMHFANMRSLIQIL 1040
            ..:::.  .|:|..|.|:.          .:||        :.|......:||    :.:||..|
Human   165 FHEMMMLFQLMVEHDHETFWLFQFFLQKTEHSC--------VINIGVAKNLDM----LSTLITFL 217

  Fly  1041 DSEMYDLMDSNGDYTHFYFCYRWFLLDFKREL-VYDDVFATWEVIWAAKHIASGHFVLFLALALL 1104
            |....:.:...|... ....:.||...|:|.. .:|||:..|||:...|  ...:|.:.:|.::|
Human   218 DPVFAEHLKGKGAGA-VQSLFPWFCFCFQRAFKSFDDVWRLWEVLLTGK--PCRNFQVLVAYSML 279

  Fly  1105 ETYRDIILSNSMDFTDVIKFFNEMAE 1130
            :..|:.:|..||...|::...|.:.:
Human   280 QMVREQVLQESMGGDDILLACNNLID 305

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tbcNP_608395.6 RUN_SGSM1_like 21..214 CDD:439049
PH_RUTBC 292..466 CDD:275431
TBC 923..1087 CDD:214540 44/176 (25%)
TBC1D21XP_006720472.1 TBC 62..287 CDD:214540 49/201 (24%)
Blue background indicates that the domain is not in the aligned region.

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