DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tbc and SGSM1

DIOPT Version :9

Sequence 1:	NP_001285494.1	Gene:	tbc / 318059	FlyBaseID:	FBgn0052506	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_001035037.1	Gene:	SGSM1 / 129049	HGNCID:	29410	Length:	1148	Species:	Homo sapiens

Alignment Length:	1269	Identity:	546/1269 - (43%)
Similarity:	733/1269 - (57%)	Gaps:	250/1269 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SDYKERLIASVKKEVKQLMEEAVTKKYVHEESSSVTSLCGAVEACLSQGLRRRALGLFKTSSTTA 73
            ::.::||:.:|||||||:||||||:|:|||:||.:.|.|.|||||:..||||||.|..:::...|
Human     8 AETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLRRRAAGFLRSNKIAA 72

  Fly    74 LLHKIAKSCPEAEHISKLVQEIEASDPSKRS--SSSSDSFQRPPMLKKSSSNSMSTGTNAAASTS 136
            |..|:.|:.|.||.:|:.||::|....|.|:  ....::.::.|.|
Human    73 LFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQENVRKLPKL------------------- 118

  Fly   137 SASASISVSASTSSMSLASMKYLWIRLALYEKRLTKIIEYLVSNASSFYDRDSLVADSDYGSILS 201
                        .::|..::|:||||.||:||.|.||:.|||.|:|.:|::::|:.|...|.||:
Human   119 ------------PNLSPLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILA 171

  Fly   202 SLLVGPCALEFTRAKTADHYWTDPHADELVQRHRI-SSCRRSSSTCSRPAIINFKRSLNTSSDEA 265
            ||||||||||:|:.|||||:||||.|||||||||| ||..|..|...|||:...||..:.|.|:.
Human   172 SLLVGPCALEYTKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSMDDR 236

  Fly   266 GTGSFKSIASASVAKDYVESLHQNAKATLLYGKNNVQVLPKDVAEPMPGYLSLHQHIQTLTIKWT 330
            .:.|         |:|||||||||::||||||||||.|.|:|..|.:||||||||....:|:|||
Human   237 PSLS---------ARDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWT 292

  Fly   331 PNQLMNGYTEAEEAEDID--KDAFWAYALNINVDEIVYVHCHQSRGEDSGGTVILVGQDGVQRPP 393
            |||||||     ...|:|  |..:|.||:.|.::||||:||||.  .||||||:||.|||:||||
Human   293 PNQLMNG-----SVGDLDYEKSVYWDYAMTIRLEEIVYLHCHQQ--VDSGGTVVLVSQDGIQRPP 350

  Fly   394 IHFPEGGHMQQFLSCLETGLLPHGQLDPPLWSQRGIGKMFLWPRSMRRRILPSVMESV-----DE 453
            ..||:|||:.|||||||.|||||||||||||||||.||:|  |: :|:|......||.     |:
Human   351 FRFPKGGHLLQFLSCLENGLLPHGQLDPPLWSQRGKGKVF--PK-LRKRSPQGSAESTSSDKDDD 412

  Fly   454 TPIDYVFRIVSKSRHEEFAATHSILDFVRST---------------------------------- 484
            ...||||||:......||.|.    ||:.||
Human   413 EATDYVFRIIYPGMQSEFVAP----DFLGSTSSVSVGPAWMMVPAGRSMLVVARGSQWEPARWDT 473

  Fly   485 --------------------------------PRRAQLSSCSTTGSSD-CSNKSLSIDQFPMESP 516
                                            ||::..||||.:||:| .|....:.::.|
Human   474 TLPTPSPKEQPPMPQDLMDVSVSNLPSLWQPSPRKSSCSSCSQSGSADGSSTNGCNHERAP---- 534

  Fly   517 LILQQQQQQQQQLLQAQSTSIEMVCSTMRRQIISRAFYGWLAYCRHLSTVRTHLSGLV-HGRITP 580
                                ::::|..|:.||:||||||||||||||||||||||.|| |..::|
Human   535 --------------------LKLLCDNMKYQILSRAFYGWLAYCRHLSTVRTHLSALVNHMIVSP 579

  Fly   581 EMKADE-EGLTKERWQLLNVNGVLENATEFYRLVYFGGVQPELRQEVWPYLLGHYAFGSTTEDRK 644
            ::..|. :|||...|:....:.......|..||:|:||:|||:|:.|||:|||||.||.|..:||
Human   580 DLPCDAGQGLTARIWEQYLHDSTSYEEQELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERK 644

  Fly   645 KQDETCKHYYETTMSEWLAVDAIVQQREKEKTARAVAKLSSGSN--------------------- 688
            :.||.....|..||:|||..:|||:|||:|..|.|:||.|||::
Human   645 EVDEQIHACYAQTMAEWLGCEAIVRQRERESHAAALAKCSSGASLDSHLHRMLHRDSTISNESSQ 709

  Fly   689 --SGNDRTVRAADLEAGGDLENEVFEDISDISDPGDLEFDEQQQQQQQQAECAVSGNHL--TVKP 749
              |...:.:|   |.:......:|||.:.::.   .:|.:.:.:::|.:..   :||.:  |..|
Human   710 SCSSGRQNIR---LHSDSSSSTQVFESVDEVE---QVEAEGRLEEKQPKIP---NGNLVNGTCSP 765

  Fly   750 IPRAMKTSTDSGHVDESFNELDEPDEEDNKQKQQQDEKISESESKLPD-YRKLEEQINQEPSCSA 813
                     ||||  .|.:.......|.::.....::.:.:::...|. .|..:..::...|..|
Human   766 ---------DSGH--PSSHNFSSGLSEHSEPSLSTEDSVLDAQRNTPTVLRPRDGSVDDRQSSEA 819

  Fly   814 STASSYETVGPGE---VHQRPNSDTRSVLS-PEYLSAD---DLQLPDDEDAVRPPPPPAAAAVII 871
            :|:   :...|.|   |.....||..:..| .|::|..   |:.||:.:|.|
Human   820 TTS---QDEAPREELAVQDSLESDLLANESMDEFMSITGSLDMALPEKDDVV------------- 868

  Fly   872 TKASVDITNWERS--PKAAEGDQMSPLEEQAGESGGAGVNMDALQQPKSACA--------SPASS 926
                  :..|..|  .|..:.|....|.|:.        .|::|....::.|        ||.||
Human   869 ------MEGWRSSETEKHGQADSEDNLSEEP--------EMESLFPALASLAVTTSANEVSPVSS 919

  Fly   927 NGGVYSSELLEQFGLNLHRIEKDVQRCDRNYWYFANENLDKLRNVISTYVWEHLDVGYMQGMCDL 991
            :|..||.|||:.:.:|||||||||||||||||||...||:||||::.:|:|:|:::||:||||||
Human   920 SGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWYFTPANLEKLRNIMCSYIWQHIEIGYVQGMCDL 984

  Fly   992 VAPLLVIFDDESLSYSCFCKLMERMIENFPSGGAMDMHFANMRSLIQILDSEMYDLMDSNGDYTH 1056
            :||||||.|||:|::|||.:||:||.:|||.|||||.|||||||||||||||:::||..||||||
Human   985 LAPLLVILDDEALAFSCFTELMKRMNQNFPHGGAMDTHFANMRSLIQILDSELFELMHQNGDYTH 1049

  Fly  1057 FYFCYRWFLLDFKRELVYDDVFATWEVIWAAKHIASGHFVLFLALALLETYRDIILSNSMDFTDV 1121
            ||||||||||||||||||||||..||.||||||::|.|:|||:||||:|.||||||.|:|||||:
Human  1050 FYFCYRWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFTDI 1114

  Fly  1122 IKFFNEMAERHNAQSVLQLARSLVLQLQMIIENK 1155
            ||||||||||||.:.||:|||.||.::|.:||||
Human  1115 IKFFNEMAERHNTKQVLKLARDLVYKVQTLIENK 1148

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_001285494.1	RUN	45..218	CDD:280855	65/174 (37%)
		PH_RUTBC	292..466	CDD:275431	107/180 (59%)
		TBC	923..1087	CDD:214540	119/163 (73%)
SGSM1	NP_001035037.1	RUN	44..188	CDD:280855	65/174 (37%)
		PH_RUTBC	254..425	CDD:275431	107/180 (59%)
		Important for interaction with RAB9A and RAB9B. /evidence=ECO:0000250\|UniProtKB:Q8BPQ7	256..297		27/40 (68%)
		Required for interaction with RAP family members	301..350		28/50 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	377..411		17/36 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	700..830		24/152 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	871..894		6/30 (20%)
		TBC	<936..1105	CDD:214540	127/168 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	297	1.000	Domainoid score	I1464
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H64485
Inparanoid	1	1.050	943	1.000	Inparanoid score	I343
Isobase	1	0.950	-	0	Normalized mean entropy	S3548
OMA	1	1.010	-	-		QHG48923
OrthoDB	1	1.010	-	-		D171826at2759
OrthoFinder	1	1.000	-	-		FOG0002045
OrthoInspector	1	1.000	-	-		mtm8482
orthoMCL	1	0.900	-	-		OOG6_103962
Panther	1	1.100	-	-	O	PTHR22957
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3416
SonicParanoid	1	1.000	-	-		X1347
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.820