Protein Alignment tbc and Tbc1d15-17

DIOPT Version :10

• Sequence 1: NP_608395.6
• Gene: tbc / 318059
• FlyBaseID: FBgn0052506
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: XP_061511086.1
• Gene: Tbc1d15-17 / 1278047
• VectorBaseID: AGAMI1_010828
• Length: 672
• Species: Anopheles gambiae
• Alignment Length: 683
• Identity: 162/683 - (23%)
• Similarity: 268/683 - (39%)
• Gaps: 199/683 - (29%)

  Fly   585 DEEGLTKERWQLLNVNGVL---ENATEFYRLVYFGGVQPELRQEVWPYLLGHYAFGSTTEDR--- 643
            :|.|:.::..|    ||||   .|||      |...:..|          |...||...:..
Mosquito     3 NESGIEEKFIQ----NGVLLKKANAT------YISVLNAE----------GILTFGQCIKTNLHV 47

  Fly   644 -KKQDETCKHYYETTMSE-----WLAVDAIVQQREKEKTARAVA---KLSSGSNSGNDRTVRAAD 699
             :.:.|||    :.|.||     |..||.|.:|...::.|:..:   ..|:.|.:|:..:.||..
Mosquito    48 FEWKPETC----DITDSESLESGWSLVDPISRQPSPQQPAQPASIACPTSTVSGTGSSPSSRATS 108

  Fly   700 LEAG------GDLENEVF-EDISDISDPGDLEFDEQQQQQQQQAECAVSGNHLTVKPIPRAMKTS 757
            .|..      ..|...|| .|:..:....|              |.....:..||..:....:||
Mosquito   109 EEPATGAPTKAKLSIRVFLRDLKGLETHKD--------------ELRFYNHDHTVHSVYLFRQTS 159

  Fly   758 TD--------------SGHVDESFNELDEPDEEDNKQKQQQDEKISE------------------ 790
            |.              |.|....:..:|:|| :|..||...:..|::
Mosquito   160 TSVLLQLLERFRCVRKSTHRKNFYRCIDDPD-QDKLQKSFSELNIADIRARPRPRPYMDMLSKLA 223

  Fly   791 ------------SESKLPDYRKLEEQINQEPSCSASTASSYETVG------PGEVHQRPNSDTRS 837
                        |:|.||...:|.....:....:|...|:.|:.|      .||.:   .::||.
Mosquito   224 NVQQILPIHRPASQSTLPGELRLSNLNARVQDAAADRHSTDESHGGVPVTDNGETN---GTETRK 285

  Fly   838 VLSPE-------YLSA---DDLQLPDDEDAVRPPPPPAAAAVI------------ITKASVDITN 880
             |:|.       .|.|   :|::.|:...:    .|.....:|            :.|..:.:..
Mosquito   286 -LAPRPPVHRGLPLDAGTWEDVKCPNGSIS----DPERVKEIIFRGGIKQDIRAEVWKYLLGLDV 345

  Fly   881 WE---------RSPKAAEGDQ-------MSPLEEQAGESGGAGVNMDALQQPKSACASPASSNGG 929
            ||         |:.|..|..|       |:|.:|.         |....::.|  |
Mosquito   346 WEHTTQQRDERRAHKTQEYFQMKFQWLTMTPTQEH---------NFTGYRERK--C--------- 390

  Fly   930 VYSSELLEQFGLNLHRIEKDVQRCDRNYWYFA---NENLDKLRNVISTYVWEHLDVGYMQGMCDL 991
                           :|||||:|.||.|.:||   |.||.||::::.|||..:.|:||:|||.||
Mosquito   391 ---------------QIEKDVKRTDRTYEFFAGDDNPNLAKLQDILMTYVMYNFDLGYVQGMSDL 440

  Fly   992 VAPLLVIFDDESLSYSCFCKLMERMIENFP-SGGAMDMHFANMRSLIQILDSEMYDLMDSNGDYT 1055
            :||:|.:..:|:.|:.||...|.::..||. ....|.:...::|.|:..::..:::.|..| ...
Mosquito   441 LAPILSLVQNEAESFWCFVGFMHKVFANFDIDQKGMKLQLEHLRVLLSFVNERLFNYMREN-QSE 504

  Fly  1056 HFYFCYRWFLLDFKRELVYDDVFATWEVIWAAKHIASGHFVLFLALALLETYRDIILSNSMDFTD 1120
            :.|||:||.|:.||||....|:...|||:|..  :...:|.||:.:|:|:...|:.:.....||:
Mosquito   505 NMYFCFRWLLVWFKREFSNSDIMHLWEVLWTG--LPCPNFHLFVCVAILDQEMDVFIDGQFSFTE 567

  Fly  1121 VIKFFNEMAERHNAQSVLQLARSLVLQLQMIIE 1153
            ::|..||::...|..:||:.|.|:.||::..::
Mosquito   568 ILKHVNELSGNLNLAAVLEQAESIYLQVKQTLD 600

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_608395.6	RUN_SGSM1_like	21..214	CDD:439049
		PH_RUTBC	292..466	CDD:275431
		TBC	923..1087	CDD:214540	57/167 (34%)
Tbc1d15-17	XP_061511086.1	None