Protein Alignment tbc and LOC1273870

DIOPT Version :10

• Sequence 1: NP_608395.6
• Gene: tbc / 318059
• FlyBaseID: FBgn0052506
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: XP_061519597.1
• Gene: LOC1273870 / 1273870
• VectorBaseID: AGAMI1_012278
• Length: 1131
• Species: Anopheles gambiae
• Alignment Length: 1206
• Identity: 760/1206 - (63%)
• Similarity: 900/1206 - (74%)
• Gaps: 145/1206 - (12%)

  Fly     6 ADGSDYKERLIASVKKEVKQLMEEAVTKKYVHEESSSVTSLCGAVEACLSQGLRRRALGLFKTSS 70
            ||..|:||:|||:|||||||:|||||||||:||||.|||:||.||||||||||||||||||||||
Mosquito    15 ADPVDFKEKLIAAVKKEVKQVMEEAVTKKYIHEESCSVTALCAAVEACLSQGLRRRALGLFKTSS 79

  Fly    71 TTALLHKIAKSCPEAEHISKLVQEIEASDPSKRSSSSSDSFQRPPMLKKSSSNSMSTGTNAAAST 135
            |||||||:||.||||..||:.||:||.|||:|||||||||..:||:|||.||||:||
Mosquito    80 TTALLHKVAKHCPEAACISRKVQDIENSDPNKRSSSSSDSTNKPPILKKGSSNSVST-------- 136

  Fly   136 SSASASISVSASTSSMSLASMKYLWIRLALYEKRLTKIIEYLVSNASSFYDRDSLVADSDYGSIL 200
                       :|...:...:||||||||||||:|::||::|||||:.:|:|||||||.||||||
Mosquito   137 -----------TTPPQTPPVVKYLWIRLALYEKKLSRIIDHLVSNATRYYERDSLVADPDYGSIL 190

  Fly   201 SSLLVGPCALEFTRAKTADHYWTDPHADELVQRHRISSCRRSSSTCSRPAIINFKRSLNTSSDEA 265
            ||||||||||:::|||||||:||||.||||||||||||...:.....|| ::||||||:|||:|.
Mosquito   191 SSLLVGPCALDYSRAKTADHFWTDPPADELVQRHRISSSNPTPPAYRRP-MLNFKRSLHTSSEEG 254

  Fly   266 GTGSFKSIASASVAKDYVESLHQNAKATLLYGKNNVQVLPKDVAEPMPGYLSLHQHIQTLTIKWT 330
            ...||||.:.||.:||||||||||::||||||||||.||||||:|||||||||||.:|:||||||
Mosquito   255 SMASFKSNSLASASKDYVESLHQNSRATLLYGKNNVLVLPKDVSEPMPGYLSLHQTVQSLTIKWT 319

  Fly   331 PNQLMNGYTEAEEAEDIDKDAFWAYALNINVDEIVYVHCHQSRGEDSGGTVILVGQDGVQRPPIH 395
            |||||||||   |:|:|||.::||||||:||||||||||||:||.|:|||:||||||||||||||
Mosquito   320 PNQLMNGYT---ESENIDKSSYWAYALNVNVDEIVYVHCHQARGGDTGGTIILVGQDGVQRPPIH 381

  Fly   396 FPEGGHMQQFLSCLETGLLPHGQLDPPLWSQRGIGKMFLWPRSMRRRILPSVMESVDETPIDYVF 460
            |||||||..||||||||||||||||||||||||||::|.||:..|||.|||::|:.||.||||||
Mosquito   382 FPEGGHMAAFLSCLETGLLPHGQLDPPLWSQRGIGRIFPWPQKSRRRPLPSLLETNDEMPIDYVF 446

  Fly   461 RIVSKSRHEEFAATHSILDFVRSTPR-RAQLSSCSTTGSSDCSNKSLSIDQFPMESPLILQQQQQ 524
            |:|:|...:||.||||||:..|::|| |||||||||..|||||:||||||...::||
Mosquito   447 RVVNKGNTDEFLATHSILELGRTSPRYRAQLSSCSTNESSDCSSKSLSIDAMSIDSP-------- 503

  Fly   525 QQQQLLQAQSTSIEMVCSTMRRQIISRAFYGWLAYCRHLSTVRTHLSGLVHGRITPEMKADEEGL 589
               .....|||||.:|||||:|||||||||||||||||||||||||||||:||||||..| |:||
Mosquito   504 ---NPQTTQSTSIALVCSTMKRQIISRAFYGWLAYCRHLSTVRTHLSGLVNGRITPETGA-EQGL 564

  Fly   590 TKERWQLL-NVNGVLENATEFYRLVYFGGVQPELRQEVWPYLLGHYAFGSTTEDRKKQDETCKHY 653
            |:.||:.| :.|||:.:..|.|||||:|||:.::|:||||||||||:||||.::|.:.|||.|||
Mosquito   565 TRSRWESLHDGNGVVADDQEVYRLVYYGGVEHDIRKEVWPYLLGHYSFGSTPDERAELDETAKHY 629

  Fly   654 YETTMSEWLAVDAIVQQREKEKTARAVAKLSSGSNSGNDRTVRAADLEAGG----------DLEN 708
            |||||||||||:|||:||:|||||.|||||||||.|..:|: :..|.:|.|          ::||
Mosquito   630 YETTMSEWLAVEAIVRQRDKEKTAVAVAKLSSGSGSMENRS-KTLDQDADGEQGEGEDEEEEMEN 693

  Fly   709 EVFED--ISDISDPGDLEFDEQQQQQQQQAECAVSGNHLTVKPIPRAMKTSTDSGHVDESFNELD 771
            ||||:  .||:|:|      |.:.:::..|:..::...:|:..:.:...|...:|....:
Mosquito   694 EVFEENGFSDMSEP------EVEGEERSDAKVQLTKETITLPVVAQDALTVETAGGAGAA----- 747

  Fly   772 EPDEEDNKQKQQQDEKISESESKLPDYRKLEEQINQEPSCSASTASSYETVGPGEVHQRPNSDTR 836
              :..|..::|:|::....::|...|                   |||.|||...:      |..
Mosquito   748 --ESADRGEEQEQEQDFDSNKSSPSD-------------------SSYATVGNDFI------DVA 785

  Fly   837 SVLSPEYLSADD------------LQLPDDEDAV--------------RPPPPPA---AAAVIIT 872
            .::||  :..:|            :|..:|||.|              .|..|.:   ..|||:|
Mosquito   786 DIISP--MGEEDSGGARSLGAVERMQEGEDEDGVTSGEGGAGPDEEEDEPDSPKSLEQPRAVIVT 848

  Fly   873 KASVDIT------------NWERSPKAAE-GDQMSPLEEQAGESGGAGVNMDALQQPKSACASPA 924
            .||:|:|            |...|..|.| |:|..|.             :|:||:|||||.|||
Mosquito   849 DASIDVTMLLPGEVRELNNNHTLSTLAEEGGNQQQPA-------------LDSLQEPKSACVSPA 900

  Fly   925 SSNGGVYSSELLEQFGLNLHRIEKDVQRCDRNYWYFANENLDKLRNVISTYVWEHLDVGYMQGMC 989
            |||||:|||||||.||||||||||||||||||||||||||||||||||.||||||||||||||||
Mosquito   901 SSNGGIYSSELLESFGLNLHRIEKDVQRCDRNYWYFANENLDKLRNVICTYVWEHLDVGYMQGMC 965

  Fly   990 DLVAPLLVIFDDESLSYSCFCKLMERMIENFPSGGAMDMHFANMRSLIQILDSEMYDLMDSNGDY 1054
            |||||||||||||||||.|||:.|||||||||:||||||||||||||||||||||||||.::|||
Mosquito   966 DLVAPLLVIFDDESLSYGCFCRFMERMIENFPNGGAMDMHFANMRSLIQILDSEMYDLMHAHGDY 1030

  Fly  1055 THFYFCYRWFLLDFKRELVYDDVFATWEVIWAAKHIASGHFVLFLALALLETYRDIILSNSMDFT 1119
            ||||||||||||||||||:|.|:|:.|||||||||:||.||||||||||||||||||||||||||
Mosquito  1031 THFYFCYRWFLLDFKRELIYADIFSVWEVIWAAKHVASAHFVLFLALALLETYRDIILSNSMDFT 1095

  Fly  1120 DVIKFFNEMAERHNAQSVLQLARSLVLQLQMIIENK 1155
            |:||||||||||||..|||:||||||||||.|||||
Mosquito  1096 DIIKFFNEMAERHNTPSVLKLARSLVLQLQTIIENK 1131

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_608395.6	RUN_SGSM1_like	21..214	CDD:439049	132/192 (69%)
		PH_RUTBC	292..466	CDD:275431	139/173 (80%)
		TBC	923..1087	CDD:214540	148/163 (91%)
LOC1273870	XP_061519597.1	None