Protein Alignment tbc and TBC1D16

DIOPT Version :10

• Sequence 1: NP_608395.6
• Gene: tbc / 318059
• FlyBaseID: FBgn0052506
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: XP_061511051.1
• Gene: TBC1D16 / 1270707
• VectorBaseID: AGAMI1_011942
• Length: 826
• Species: Anopheles gambiae
• Alignment Length: 895
• Identity: 167/895 - (18%)
• Similarity: 262/895 - (29%)
• Gaps: 404/895 - (45%)

  Fly   336 NGYTEAEEAEDIDKDAFWAYALNINVDE--IVYVHCHQSRGEDSGGTVILVGQDGVQRPPI--HF 396
            |.|...::..| |:|         :|||  ||....|.|.....||       ||.....:  ..
Mosquito   210 NDYDGRDDGPD-DED---------DVDEGCIVTSEAHHSTASVGGG-------DGAANDLLEEEE 257

  Fly   397 PEGGHMQQFLSCLE---------------TGLLPHGQLDPPLWSQRGIGKMFLWPRSMRRRILPS 446
            .|.|...:..:.|:               ||.|.|....|   ||..:       .|:...|...
Mosquito   258 EEEGEDAELKTELQPLLEDGTKLSAAGGGTGKLHHHHKLP---SQSSV-------TSVNITIASP 312

  Fly   447 VMESVDETPIDYVFRIVSKSRHEEFAATHSILDFVRSTPRRAQLSSCSTTGSSDCSN-------- 503
            .:::||.:|.:     .:....|.|                  |.|.|.| |||.:|
Mosquito   313 HIQNVDISPPE-----ATLPATERF------------------LRSLSIT-SSDENNPNWMSPEL 353

  Fly   504 ----KSLSIDQFPMESPLI--------------LQQQQQQQQQLLQAQSTSIEMVCSTMRRQI-I 549
                .:|:..:....||::              |.|.:..:......|.||.::|.::...|. |
Mosquito   354 LAYKHNLAFPESASASPIVSRKAPLKCRRFSVDLSQMRALRLFFNDEQCTSGQLVIASRESQYKI 418

  Fly   550 SRAFYGWLAYCRHLSTVRTHLSGLVHG-----------------------RITPEMKADEEG--- 588
            ....:|.|   .||:.|......|:|.                       .:.|.....|||
Mosquito   419 LHFHHGGL---DHLAQVLHQWHCLLHNIKLAPGQDEPANVPYRQFMVCRPEVRPAELHPEEGKVS 480

  Fly   589 -LTKERW--QLLNVNGVLENATEFYRLVYFGGVQPELRQEVWPYLLGHYAFGSTTEDRKKQDETC 650
             :|.:.:  .|||..|.:|:..:..:.|:|||:...||:.|||:||..|:.|||.|||
Mosquito   481 KITTDYFYGTLLNERGQIEDDLQLRKCVFFGGLDRSLRKTVWPFLLHCYSTGSTFEDR------- 538

  Fly   651 KHYYETTMSEWLAVDAIVQQREKEKTARAVAKLSSGSNSGNDRTVRAADLEAGGDLENEVFEDIS 715
                       .|:..|.:|..:|.|.|.:..:|
Mosquito   539 -----------AALGEIRRQEYEEITRRRLYSMS------------------------------- 561

  Fly   716 DISDPGDLEFDEQQQQQQQQAECAVSGNHLTVKPIPRAMKTSTDSGHVDESFNELDEPDEEDNKQ 780
                      .|.|.|..:..:|.
Mosquito   562 ----------PEAQAQFWRTVQCV----------------------------------------- 575

  Fly   781 KQQQDEKISESESKLPDYRKLEEQINQEPSCSASTASSYETVGPGEVHQRPNSDTRSVLSPEYLS 845
                                                                             
Mosquito   576 ----------------------------------------------------------------- 575

  Fly   846 ADDLQLPDDEDAVRPPPPPAAAAVIITKASVDITNWERSPKAAEGDQMSPLEEQAGESGGAGVNM 910
                                                                             
Mosquito   576 ----------------------------------------------------------------- 575

  Fly   911 DALQQPKSACASPASSNGGVYSSELLEQFGLNLHRIEKDVQRCDRNYWYFA---NENLDKLRNVI 972
                                               |||||.|.||...:||   |.|:|.::|::
Mosquito   576 -----------------------------------IEKDVVRTDRGNPFFAGDDNPNIDTMKNIL 605

  Fly   973 STYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKLMERMIENF---PSGGAMDMHFANMR 1034
            ..|.:.:..:.|.|||.||:||:|.....||.::.||..||:|.|  |   |:...:|.:...:|
Mosquito   606 LNYAFYNPGMSYTQGMSDLLAPVLCEIKSESETFWCFVGLMQRAI--FVCTPTDNDIDRNLCYLR 668

  Fly  1035 SLIQILDSEMYDLMDSNGDYTHFYFCYRWFLLDFKRELVYDDVFATWEVIWAAKHIASGHFVLFL 1099
            .||:::....|..:..:.|.....||:||.||.||||.........||..|:  :..:.:|.|||
Mosquito   669 ELIRLMVPNFYKHLQKHADAMELLFCHRWILLCFKREFTEAVAIRMWEACWS--NYLTDYFHLFL 731

  Fly  1100 ALALLETYRDIILSNSMDFTDVIKFFNEMAERHNAQSVLQLARSLVLQLQ 1149
            .||::..|.|.:::..:...:::..|:.:|...:.|.:|:.||.|:.|.:
Mosquito   732 CLAIIAVYADDVIAQDLRTDEMLLHFSSLAMYMDGQLILRKARGLLHQFR 781

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_608395.6	RUN_SGSM1_like	21..214	CDD:439049
		PH_RUTBC	292..466	CDD:275431	31/148 (21%)
		TBC	923..1087	CDD:214540	53/169 (31%)
TBC1D16	XP_061511051.1	None