Protein Alignment tbc and TBC1D16

DIOPT Version :10

• Sequence 1: NP_608395.6
• Gene: tbc / 318059
• FlyBaseID: FBgn0052506
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: XP_024306345.1
• Gene: TBC1D16 / 125058
• HGNCID: 28356
• Length: 824
• Species: Homo sapiens
• Alignment Length: 762
• Identity: 162/762 - (21%)
• Similarity: 249/762 - (32%)
• Gaps: 296/762 - (38%)

  Fly   670 QREKEKTARAVAKLSSGSNSGNDRTVRAADLEAGGDLENEVF-----------EDISDISD--PG 721
            :|...|.:..:.....||.||:...           |:.|:.           |.:..:.:  ||
Human     8 RRASSKASDLLTLTPGGSGSGSPSV-----------LDGEIIYSKNNVCVHPPEGLQGLGEHHPG 61

  Fly   722 DL----EFDE--------------QQQQQQQQAECAVSGNHLTVK--PIPRAMKTSTDSGHVDES 766
            .|    |.||              :.|:|.::|...::.....|:  |.||..:|.:.......|
Human    62 YLCLYMEKDEMLGATLILAWVPNSRIQRQDEEALRYITPESSPVRKAPRPRGRRTRSSGASHQPS 126

  Fly   767 FNELD---EPDEEDNKQKQQQ--DEKIS----ESESKLPDYRKLE-EQINQEPSCSASTASSYET 821
            ..||.   .|.:||.....|.  |..::    |.|.||.....:: .|...:|:||.|...|  |
Human   127 PTELRPTLTPKDEDILVVAQSVPDRMLASPAPEDEEKLAQGLGVDGAQPASQPACSPSGILS--T 189

  Fly   822 VGPGEVHQ-----RPNS---DTRSVLSPEYLSADDLQLPDDEDAVRPP--PPPAAAAVIITKASV 876
            |.|.:|.:     ||.:   |....||.|.:|.|. ....|.|....|  ..|.:||:..::.||
Human   190 VSPQDVTEEGREPRPEAGEEDGSLELSAEGVSRDS-SFDSDSDTFSSPFCLSPISAALAESRGSV 253

  Fly   877 -------------------DITNWERSPKAAEGDQMSPLEEQAG--------------------- 901
                               |.....::|:..|..::..||:..|
Human   254 FLESDSSPPSSSDAGLRFPDSNGLLQTPRWDEPQRVCALEQICGVFRVDLGHMRSLRLFFSDEAC 318

  Fly   902 ----------ES---------GGAGVNMDALQQ---------------PKSACAS--------PA 924
                      ||         ||.....|..||               |...|..        |:
Human   319 TSGQLVVASRESQYKVFHFHHGGLDKLSDVFQQWKYCTEMQLKDQQVAPDKTCMQFSIRRPKLPS 383

  Fly   925 SSN-------------------------------------GGV---------------YSSEL-- 935
            |..                                     ||:               ||.|.
Human   384 SETHPEESMYKRLGVSAWLNHLNELGQVEEEYKLRKAIFFGGIDVSIRGEVWPFLLRYYSHESTS 448

  Fly   936 ----------------LEQFGLNL----HR---------IEKDVQRCDRNYWYFA---NENLDKL 968
                            ::|..|::    ||         ::|||.|.|||..:|.   |.|::.:
Human   449 EEREALRLQKRKEYSEIQQKRLSMTPEEHRAFWRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESM 513

  Fly   969 RNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKL--------------MERMIE- 1018
            |.::..|...:..|||.|||.|||||:|....|||.::.||..|              ||:.:|
Human   514 RRILLNYAVYNPAVGYSQGMSDLVAPILAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQLEE 578

  Fly  1019 --------------NFPSGGA---------------MDMHFAN--------------MRSLIQIL 1040
                          :.|..||               :|...|:              :|.|:::.
Human   579 WTWETAPKCALRVGSLPGHGAAASVLPRPGTTLCLTLDHTTASGTVRSGRNWQRQLYLRELLRLT 643

  Fly  1041 DSEMYDLMDSNG-DYTHFYFCYRWFLLDFKRELVYDDVFATWEVIWAAKHIASGHFVLFLALALL 1104
            ....|..:.|.| |.....||:||.||.||||....:....||..||  |..:.:|.||:.:|::
Human   644 HVRFYQHLVSLGEDGLQMLFCHRWLLLCFKREFPEAEALRIWEACWA--HYQTDYFHLFICVAIV 706

  Fly  1105 ETYRDIILSNSMDFTDVIKFFNEMAERHNAQSVLQLARSLVLQLQMI 1151
            ..|.|.::...:....::..|..:|...|.:.||:.||||:.|.:::
Human   707 AIYGDDVIEQQLATDQMLLHFGNLAMHMNGELVLRKARSLLYQFRLL 753

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_608395.6	RUN_SGSM1_like	21..214	CDD:439049
		PH_RUTBC	292..466	CDD:275431
		TBC	923..1087	CDD:214540	68/308 (22%)
TBC1D16	XP_024306345.1	TBC	424..709	CDD:214540	72/286 (25%)