Protein Alignment tbc and TBC1D8

DIOPT Version :10

• Sequence 1: NP_608395.6
• Gene: tbc / 318059
• FlyBaseID: FBgn0052506
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: NP_001317277.1
• Gene: TBC1D8 / 11138
• HGNCID: 17791
• Length: 1155
• Species: Homo sapiens
• Alignment Length: 729
• Identity: 130/729 - (17%)
• Similarity: 234/729 - (32%)
• Gaps: 225/729 - (30%)

  Fly   564 STVRTHLSGLVHGRITPEMKADEEGLTKERWQLLNVNG-----VLENATEFYRLVYFGGVQPELR 623
            |.|:..:..|:....:..:...||...|.|..|:....     ..|....:|....:.|..|
Human   127 SFVKGKVKALIAEETSSRLAEQEEEPEKFREALVKFEARFNFPEAEKLVTYYSCCCWKGRVP--- 188

  Fly   624 QEVWPYL-LGH---YAFGSTTE--------DRKKQDETCKHYYETTM-----------SEWLAVD 665
            ::.|.|| :.|   |:|....|        |.:|.:.|...:...|:           |.:|.:|
Human   189 RQGWLYLSINHLCFYSFFLGKELKLVVPWVDIQKLERTSNVFLTDTIRITTQNKERDFSMFLNLD 253

  Fly   666 AIVQQREKEKTARAVAKLSSGSNSGNDRTVRAADLEAGGDLENEVFEDISDISDPG-----DLEF 725
            .:.:..|                       :.||:.....|:||||:...|:.:|.     |||.
Human   254 EVFKVME-----------------------QLADVTLRRLLDNEVFDLDPDLQEPSQITKRDLEA 295

  Fly   726 DEQQQ--------QQQQQAECAVSGNHLTVKPIPRAMKT----STDS----GHVDESFNELDEPD 774
            ..|.:        .::::....|..:..|  |..|...|    ::||    ...::...::..|.
Human   296 RAQNEFFRAFFRLPRKEKLHAVVDCSLWT--PFSRCHTTGRMFASDSYICFASREDGCCKIILPL 358

  Fly   775 EEDNKQKQQQD-------------EKISESESKLPDYRKLEE-------------QINQEPSCSA 813
            .|....::.:|             .|::....:|.|...|.|             .::.:.|...
Human   359 REVVSIEKMEDTSLLPHPIIVSIRSKVAFQFIELRDRDSLVEALLARLKQVHANHPVHYDTSADD 423

  Fly   814 STAS---------SYETVGPGEVHQRPNSDTRSVLSPEYLSADDL---------QLPDDEDAVRP 860
            ..||         |....|..|:....||:.........:..|.|         |.||..
Human   424 DMASLVFHSTSMCSDHRFGDLEMMSSQNSEESEKEKSPLMHPDALVTAFQQSGSQSPDSR----- 483

  Fly   861 PPPPAAAAVIITKASVDITNWE-------------RSPKAAEGDQMSPLEEQAGESGGAGVNMDA 912
                      :::..:.|:.|.             |:.|..:...|...|...|.
Human   484 ----------MSREQIKISLWNDHFVEYGRTVCMFRTEKIRKLVAMGIPESLRGR---------- 528

  Fly   913 LQQPKSACASPASSNGGVYSSELLEQFG---LNLHRIEKDVQRCDRNYWYFANE-NLDKLRNVIS 973
            |....|...:..:|:.|.|.:.:.|..|   |....||:|:.|....:..|.|| .:..||.|::
Human   529 LWLLFSDAVTDLASHPGYYGNLVEESLGKCCLVTEEIERDLHRSLPEHPAFQNETGIAALRRVLT 593

  Fly   974 TYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKLMERMIENFPS----GGAMDMHFANMR 1034
            .|...:..:||.|.| :::..:|:::..|..::.....:.|||:.::.:    |..:|.....
Human   594 AYAHRNPKIGYCQSM-NILTSVLLLYTKEEEAFWLLVAVCERMLPDYFNHRVIGAQVDQSVFE-- 655

  Fly  1035 SLIQILDSEMYDLMDSNGDYTHF-YFCYRWFLLDFKREL------------VYDDVFATWEVIWA 1086
               :::...:.:|.:...|.:.. .....|||..|...:            .||.:.|.::
Human   656 ---ELIKGHLPELAEHMNDLSALASVSLSWFLTLFLSIMPLESAVNVVDCFFYDGIKAIFQ---- 713

  Fly  1087 AKHIASGHFVLFLALALLETYRDIILSNSMD---------FTDVIK--------------FFNEM 1128
                        |.||:||...:.:.|:..|         |.|.||              ||::.
Human   714 ------------LGLAVLEANAEDLCSSKDDGQALMILSRFLDHIKNEDSPGPPVGSHHAFFSDD 766

  Fly  1129 AERHNAQSVLQLAR 1142
            .|.:....:..|.|
Human   767 QEPYPVTDISDLIR 780

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_608395.6	RUN_SGSM1_like	21..214	CDD:439049
		PH_RUTBC	292..466	CDD:275431
		TBC	923..1087	CDD:214540	37/184 (20%)
TBC1D8	NP_001317277.1	PH-GRAM1_TBC1D8	171..269	CDD:270156	21/123 (17%)
		PH-GRAM2_TBC1D8	311..406	CDD:270160	15/96 (16%)
		TBC	520..726	CDD:214540	46/237 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1046..1085