DRSC/TRiP Functional Genomics Resources

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Protein Alignment tbc and TBC1D3L

DIOPT Version :10

Sequence 1:NP_608395.6 Gene:tbc / 318059 FlyBaseID:FBgn0052506 Length:1155 Species:Drosophila melanogaster
Sequence 2:NP_001356428.1 Gene:TBC1D3L / 101060376 HGNCID:51246 Length:610 Species:Homo sapiens


Alignment Length:594 Identity:109/594 - (18%)
Similarity:167/594 - (28%) Gaps:237/594 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   480 FVRSTPRRAQLSSCSTTGSSDCSNKSL-SIDQFPMESPLILQQQQQQQQQLLQAQSTSIEMVCST 543
            |..|.||...|       .:.||:.:| .:.....|.|.:..::.:|.::.:..:|..::|:...
Human    89 FWGSAPRLGPL-------QAPCSSSALPGLPYSETELPPLTAREAKQIRREISRKSKWVDMLGDW 146

  Fly   544 MR----RQIISRAFYG---------WLAYCRHLSTVRTHLSGLVHGRITPEMKADEEGLTKERWQ 595
            .:    |::|.||:.|         |              |.|::   |.|||....|    |:|
Human   147 EKYKSSRKLIDRAYKGMPMNIRGPMW--------------SVLLN---TEEMKLKNPG----RYQ 190

  Fly   596 LL----------------NVNGVLENATEFYRLVYFGGVQPELRQEVWPYLLGHYAFGSTTEDRK 644
            ::                :|:|.|.... |:|..| |..|.||...:..|           |:..
Human   191 IMKEKGKRSSEHIQRIDRDVSGTLRKHI-FFRDRY-GTKQRELLHILLAY-----------EEYN 242

  Fly   645 KQDETCKH----------YYETTMSEWLAVDAIVQQREKEKTARAVAKLSSGSNSGNDRTVRAAD 699
            .:...|:.          |.....:.|..|..:..:|..          ..|.:|.|..||    
Human   243 PEVGYCRDLSHIAALFLLYLPEEDAFWALVQLLASERHS----------LQGFHSPNGGTV---- 293

  Fly   700 LEAGGDLENEVFEDISDISDPGDLEFDEQQQQQQQQAECAVSGNHLTVKPIPRAMKTSTDSGHVD 764
                                        |..|.||:        |:.....|:.|      ||  
Human   294 ----------------------------QGLQDQQE--------HVVATSQPKTM------GH-- 314

  Fly   765 ESFNELDEPDEEDNKQKQQQ------------------------DEKISESESKLPDYRKLEEQI 805
                       :|.|....|                        |..:.|.|..|....::..::
Human   315 -----------QDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPITRIAFKV 368

  Fly   806 NQEPSCSAST---------------ASSYETV-----GPGEVHQRPNSDTRSVLSPEYLSADDLQ 850
            .|:.....|.               |...:||     ...:...|...|.:....||..|:....
Human   369 QQKRLTKTSRCGPWARFCNRFVDTWARDEDTVLKHLRASMKKLTRKQGDLQPPAKPEQGSSASRP 433

  Fly   851 LPDDE--------DAVRPPPPPAAAAVIITKASVDITNWERSPKAAEGDQMSPLEEQAGESGGAG 907
            :|...        |...||.|||.....|..||        .|:|.......|        ||| 
Human   434 VPASRGGKTLCKGDRQAPPGPPARFPRPIWSAS--------PPRAPRSSTPCP--------GGA- 481

  Fly   908 VNMDALQQPKSACASPASSNGGVYSSELLEQFGLNLHRIEKDV-------------QRCDRNYWY 959
            |..|..........|||.:.||...|....|:. ::.|:..|:             |.|    |.
Human   482 VREDTYPVGTQGVPSPALAQGGPQGSWRFLQWN-SMPRLPTDLDVEGPWFRHYDFRQSC----WV 541

  Fly   960 FANENLDKL 968
            .|....|:|
Human   542 RAISQEDQL 550

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tbcNP_608395.6 RUN_SGSM1_like 21..214 CDD:439049
PH_RUTBC 292..466 CDD:275431
TBC 923..1087 CDD:214540 14/59 (24%)
TBC1D3LNP_001356428.1 TBC 160..373 CDD:214540 50/315 (16%)
PHA03381 <417..>529 CDD:177618 31/129 (24%)
Blue background indicates that the domain is not in the aligned region.

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