DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tbc and Tbc1d14

DIOPT Version :9

Sequence 1:	NP_001285494.1	Gene:	tbc / 318059	FlyBaseID:	FBgn0052506	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_001106833.1	Gene:	Tbc1d14 / 100855	MGIID:	1098708	Length:	714	Species:	Mus musculus

Alignment Length:	436	Identity:	89/436 - (20%)
Similarity:	152/436 - (34%)	Gaps:	129/436 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   764 DESFNELDEPDEEDNKQKQQQDEKISESESK-LPDYRKLEEQINQEPSCSASTASSYETVGPGEV 827
            |...|...:|.||..|.:||.:|.:.:::.: |.:.::..:|:  |..|...     |::|..
Mouse   339 DRPANLPAKPAEEAQKHRQQYEEMVLQAKKRELKEAQRRRKQL--EERCKVE-----ESIGNA-- 394

  Fly   828 HQRPNSDTRSVLSPEYLSADDLQLPDDEDAVRPPPPPAAAAVIITKASVDITNWERSPKAAEGDQ 892
                           .|:.::..||:.|            .:..:|...|:. |:..|.:..|..
Mouse   395 ---------------VLTWNNEILPNWE------------TMWCSKKVRDLW-WQGIPPSVRGKV 431

  Fly   893 MSPLEEQAGESGGAGVNMDALQQPKSACASPAS------SNGGVYSSEL-LEQFGL-------NL 943
            .|.         ..|..::...:....|.:.|.      |.||   ||: .|..|.       :|
Mouse   432 WSL---------AIGNELNITHELFDICLARAKERWRSLSTGG---SEVENEDAGFSAADREASL 484

  Fly   944 HRIEKDVQRCDRNYWYF--ANENLDKLRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSY 1006
            ..|:.|:.|...|...|  .....|.|.:::..|.....||||:||| ..:|.:|::..|.:.::
Mouse   485 ELIKLDISRTFPNLCIFQQGGPYHDMLHSILGAYTCYRPDVGYVQGM-SFIAAVLILNLDTADAF 548

  Fly  1007 SCFCKLMER-------------MI-----------ENFPSGGAMDMHFA--NMRSLIQILDSEMY 1045
            ..|..|:.:             |:           ||.|.   :..||.  |:.:.|.::|
Mouse   549 IAFSNLLNKPCQMAFFRVDHGLMLTYFAAFEVFFEENLPK---LFAHFKKNNLTADIYLID---- 606

  Fly  1046 DLMDSNGDYTHFYFCYRWFLLDFKRELVYDDVFATWEVIWAAKHIASGHFVLF-LALALLETYRD 1109
                             |....:.:.|..|.....|:|.     ...|...|| .||.:|:.:.|
Mouse   607 -----------------WIFTLYSKSLPLDLACRIWDVF-----CRDGEEFLFRTALGILKLFED 649

  Fly  1110 IILSNSMDFTDVIKFFNEMAERHNAQSVLQLARSLVLQLQMIIENK 1155
            |:  ..|||....:|...:.|...|..|.    :.:..:||...||
Mouse   650 IL--TRMDFIHSAQFLTRLPEDLPADEVF----AAISTVQMQSRNK 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_001285494.1	RUN	45..218	CDD:280855
		PH_RUTBC	292..466	CDD:275431
		TBC	923..1087	CDD:214540	43/205 (21%)
Tbc1d14	NP_001106833.1	ARGLU	<350..>392	CDD:373772	11/48 (23%)
Tbc1d14	NP_001106833.1	TBC	419..651	CDD:214540	56/274 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900