DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tbc and sgsm1b

DIOPT Version :9

Sequence 1:	NP_001285494.1	Gene:	tbc / 318059	FlyBaseID:	FBgn0052506	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	XP_003199319.1	Gene:	sgsm1b / 100535556	ZFINID:	ZDB-GENE-091117-39	Length:	1533	Species:	Danio rerio

Alignment Length:	1617	Identity:	576/1617 - (35%)
Similarity:	775/1617 - (47%)	Gaps:	557/1617 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SDYKERLIASVKKEVKQLMEEAVTKKYVHEESSSVTSLCGAVEACLSQGLRRRALGLFKTSSTTA 73
            |:.::||:.:|||||||:||||||:|:|||:||.:.|.||.||||:..||:|||.|..:::...|
Zfish     4 SETRQRLLRNVKKEVKQIMEEAVTRKFVHEDSSHIISFCGVVEACVLHGLKRRAAGFLRSNKLAA 68

  Fly    74 LLHKIAKSCPEAEHISKLVQEIEASDPSKRSSS--SSDSFQ---RPPMLKKSSSNSMSTGTNAAA 133
            |..|:.|..|.||.:.:.|||:|....:|::.|  |.:|.:   |||
Zfish    69 LFMKVGKMFPPAEDLCRKVQELEQIIENKQNQSQMSQESVRKQPRPP------------------ 115

  Fly   134 STSSASASISVSASTSSMSLASMKYLWIRLALYEKRLTKIIEYLVSNASSFYDRDSLVADSDYGS 198
                            ::|..::|:||||.||.:|.|.||:.|||.|:|.||:|::|:.|...|.
Zfish   116 ----------------NLSPLAIKHLWIRTALTQKLLDKIVLYLVENSSKFYEREALLRDPVDGP 164

  Fly   199 ILSSLLVGPCALEFTRAKTADHYWTDPHADELVQRHRISS--CRRSSSTCSRPAIINFKRSLNTS 261
            ||:||||||||||:|:||||:|:||||.||||||||||.|  ||:.|.| .|||:|..::|..:.
Zfish   165 ILASLLVGPCALEYTKAKTANHFWTDPSADELVQRHRIHSGHCRQDSPT-KRPALIQKRQSSGSM 228

  Fly   262 SDEAGTGSFKSIASASVAKDYVESLHQNAKATLLYGKNNVQVLPKDVAEPMPGYLSLHQHIQTLT 326
            .|.....          |:|||||||||::||||:|||||.|.|.|..|.:||||||||....:|
Zfish   229 DDRPSLW----------ARDYVESLHQNSRATLLFGKNNVLVQPTDDMEAIPGYLSLHQTADLMT 283

  Fly   327 IKWTPNQLMNGYTEAEEAEDIDKDAFWAYALNINVDEIVYVHCHQSRGEDSGGTVILVGQDGVQR 391
            :||||||||||.||.    |.:|..:|.:|:.|.::||||:||||.  .||||||:||.|||:||
Zfish   284 LKWTPNQLMNGNTEF----DYEKSVYWDFAMTIRLEEIVYLHCHQQ--VDSGGTVVLVSQDGIQR 342

  Fly   392 PPIHFPEGGHMQQFLSCLETGLLPHGQLDPPLWSQRGIGKMFLWPRSMRRRILPSVMESV----D 452
            ||..||:|||:.|||:|||||||||||||||||||||.||:|  |: :|:|......||.    :
Zfish   343 PPFRFPKGGHLLQFLTCLETGLLPHGQLDPPLWSQRGKGKVF--PK-LRKRSPHGSCESFSDKDE 404

  Fly   453 ETPIDYVFRIVSKSRHEEFAATHSI---LDFVRSTPRRAQLSSCSTTGSSD------CSNKSLSI 508
            :...||||||:... .:||.|...|   ::..:.|||::..||||..||||      |::
Zfish   405 DEATDYVFRIIYPG-SQEFVAPELIEQAVNMWQPTPRKSSCSSCSQNGSSDGGLPNGCNH----- 463

  Fly   509 DQFPMESPLILQQQQQQQQQLLQAQSTSIEMVCSTMRRQIISRAFYGWLAYCRHLSTVRTHLSGL 573
            |:.|                        ::::|.||:.|||||||||||||||||||||||||.|
Zfish   464 DRAP------------------------LKLLCETMKHQIISRAFYGWLAYCRHLSTVRTHLSAL 504

  Fly   574 VHGRIT-PEMKADEE-GLTKERWQLLNVNGVLENATEFYRLVYFGGVQPELRQEVWPYLLGHYAF 636
            |:..|. |::..|.: ||:.:.|:....:.......|..||||:|||:|.||:||||:|||||.|
Zfish   505 VNATIVEPDIPYDAKGGLSADVWKSFLQDCSAYEEEELLRLVYYGGVEPSLRKEVWPFLLGHYHF 569

  Fly   637 GSTTEDRKKQDETCKHYYETTMSEWLAVDAIVQQREKEKTARAVAKLSSGSN----SGNDRTVRA 697
            ..:.|:||:.||..:..||.||||||..:|||:|||||:.|.|:||..||::    |..|.|:..
Zfish   570 TMSPEERKEVDEQIRACYEQTMSEWLGCEAIVRQREKEQHAAALAKCVSGASVDRGSRQDSTIST 634

  Fly   698 -------------ADLEAGGDLENEVFEDISDISDPGDLE---FDEQQQQQ-------------- 732
                         |...:..:...:||..:.:: ||.:.|   .||:.|.:
Zfish   635 DSSQSSNSDKQSHAGSHSDSNSSTQVFGSVDEV-DPIESEPKPKDEKPQPKIPNGALPNCTSSPD 698

  Fly   733 ------------QQQAECAVS----------GNHLTVKPIPR----------------AMKTSTD 759
                        ...::|:.|          ||...::..|:                |:.|..:
Zfish   699 SGHPSSRNFSVTSAMSDCSPSAEETSTQESKGNQPDIEEKPKEEQPENSSTTQDTDKAAITTQNE 763

  Fly   760 S----------------GHVDESFNELDEPDE--------------------------------- 775
            |                ..:.::...|.||.|
Zfish   764 SKLQTSETSRAETDQIKDAISKNPTNLSEPKEDEVNPGAEADARKSEVNKCEVQPLKDPAEESRS 828

  Fly   776 ----------------------------------EDNKQKQQ------QDEKISE---SESKLPD 797
                                              ||:|.:|.      :|..||:   ||||...
Zfish   829 SESKQAEDADPVSLSIVDEDTKSNTEQEIGLKVNEDSKSQQSAPESTPEDVNISQNLSSESKTGQ 893

  Fly   798 YRKLEEQINQEPSCSAST--------ASSYETVGPGEVHQRPNSDTRSVLSPEYLSADD------ 848
            ...|  ::|::|.|..||        .:|........:.|:.|.|::|..|.....:||
Zfish   894 ETGL--KVNEDPKCQQSTPESTSDCMKTSQSLSSESNMEQKANEDSKSQQSAPESKSDDVKTSQN 956

  Fly   849 ------------LQLPDD------------------------------------EDA-VRPPPPP 864
                        |::.:|                                    ||: .:|..|.
Zfish   957 LSSGSNTKQETSLKVSEDSNCQPSAPESTSEAMKTSQNLSSESNTEQETGLKVNEDSKCQPSAPE 1021

  Fly   865 AAAAVIIT------------------------------------------------------KAS 875
            :.:..:.|                                                      |.:
Zfish  1022 STSEAMKTSQNLSSESNTEQETGLKVNEDSKCQPSAPESTPEHMKTSQNLSSESNTEQETGLKVN 1086

  Fly   876 VDITNWERSPKA----------------------------------------------------- 887
            .|..:.:.:||:
Zfish  1087 KDSKSEQSAPKSTPEHMKTCLNLSSELNMEQATGLKVNKDSKCQPSAPESTLDDMKTSQNLSSGP 1151

  Fly   888 -----------------------------AEGDQMSPL--------------------EE----- 898
                                         :|.:...||                    ||
Zfish  1152 QNVPQTAPQTISWDSEHNRARSIIKQMTESESESCGPLTSLSKPSPDMSDDSPSALEMEEIPSSV 1216

  Fly   899 ------------------------QAGESGGAGV---------------------------NMD- 911
                                    .|||....|:                           .||
Zfish  1217 VYMSSESSMCRTPLTLARPVAPCIAAGEKSPMGMPALELCMEPGVNTTPEGTDSALSEEEPEMDN 1281

  Fly   912 --------ALQQPKSACASPASSNGGVYSSELLEQFGLNLHRIEKDVQRCDRNYWYFANENLDKL 968
                    |:...|:..|||.||.|..||.||::.:.||||||:|||||||||||||...||:||
Zfish  1282 LFPKPDSLAVTGDKNDIASPVSSIGTTYSQELVDLYTLNLHRIDKDVQRCDRNYWYFTPANLEKL 1346

  Fly   969 RNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKLMERMIENFPSGGAMDMHFANM 1033
            ||::.:|||:|||:||:||||||:||||||.|||::::|||.:||:||.:|||.|||||.|||||
Zfish  1347 RNIMCSYVWQHLDIGYVQGMCDLLAPLLVILDDEAMAFSCFTELMKRMNQNFPHGGAMDTHFANM 1411

  Fly  1034 RSLIQILDSEMYDLMDSNGDYTHFYFCYRWFLLDFKRELVYDDVFATWEVIWAAKHIASGHFVLF 1098
            ||||||||||:::||..|||||||||||||||||||||:||||||:.||.||||::.:|.|||||
Zfish  1412 RSLIQILDSELFELMQQNGDYTHFYFCYRWFLLDFKREMVYDDVFSVWETIWAARYASSEHFVLF 1476

  Fly  1099 LALALLETYRDIILSNSMDFTDVIKFFNEMAERHNAQSVLQLARSLVLQLQMIIENK 1155
            :||||:|.||||||.|:|||||:|||||||||||:...:|.:||.||.::|::||||
Zfish  1477 IALALVELYRDIILENNMDFTDIIKFFNEMAERHDVPKLLVMARDLVHKVQILIENK 1533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_001285494.1	RUN	45..218	CDD:280855	69/177 (39%)
		PH_RUTBC	292..466	CDD:275431	105/177 (59%)
		TBC	923..1087	CDD:214540	119/163 (73%)
sgsm1b	XP_003199319.1	RUN	40..184	CDD:280855	69/177 (39%)
		PH_RUTBC	249..418	CDD:275431	105/177 (59%)
		Ehrlichia_rpt	652..1218	CDD:118064	61/568 (11%)
		TBC	<1321..1490	CDD:214540	126/168 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	203	1.000	Domainoid score	I2914
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H64485
Inparanoid	1	1.050	942	1.000	Inparanoid score	I333
OMA	1	1.010	-	-		QHG48923
OrthoDB	1	1.010	-	-		D171826at2759
OrthoFinder	1	1.000	-	-		FOG0002045
OrthoInspector	1	1.000	-	-		mtm6445
orthoMCL	1	0.900	-	-		OOG6_103962
Panther	1	1.100	-	-	O	PTHR22957
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3416
SonicParanoid	1	1.000	-	-		X1347
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	12.010