Protein Alignment tbc and sgsm1b

DIOPT Version :10

• Sequence 1: NP_608395.6
• Gene: tbc / 318059
• FlyBaseID: FBgn0052506
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: XP_073770421.1
• Gene: sgsm1b / 100535556
• ZFINID: ZDB-GENE-091117-39
• Length: 1497
• Species: Danio rerio
• Alignment Length: 1581
• Identity: 576/1581 - (36%)
• Similarity: 777/1581 - (49%)
• Gaps: 521/1581 - (32%)

  Fly     9 SDYKERLIASVKKEVKQLMEEAVTKKYVHEESSSVTSLCGAVEACLSQGLRRRALGLFKTSSTTA 73
            |:.::||:.:|||||||:||||||:|:|||:||.:.|.||.||||:..||:|||.|..:::...|
Zfish     4 SETRQRLLRNVKKEVKQIMEEAVTRKFVHEDSSHIISFCGVVEACVLHGLKRRAAGFLRSNKLAA 68

  Fly    74 LLHKIAKSCPEAEHISKLVQEIEASDPSKRSSS--SSDSFQ---RPPMLKKSSSNSMSTGTNAAA 133
            |..|:.|..|.||.:.:.|||:|....:|::.|  |.:|.:   |||
Zfish    69 LFMKVGKMFPPAEDLCRKVQELEQIIENKQNQSQMSQESVRKQPRPP------------------ 115

  Fly   134 STSSASASISVSASTSSMSLASMKYLWIRLALYEKRLTKIIEYLVSNASSFYDRDSLVADSDYGS 198
                            ::|..::|:||||.||.:|.|.||:.|||.|:|.||:|::|:.|...|.
Zfish   116 ----------------NLSPLAIKHLWIRTALTQKLLDKIVLYLVENSSKFYEREALLRDPVDGP 164

  Fly   199 ILSSLLVGPCALEFTRAKTADHYWTDPHADELVQRHRISS--CRRSSSTCSRPAIINFKRSLNTS 261
            ||:||||||||||:|:||||:|:||||.||||||||||.|  ||:.|.| .|||:|..::|..:.
Zfish   165 ILASLLVGPCALEYTKAKTANHFWTDPSADELVQRHRIHSGHCRQDSPT-KRPALIQKRQSSGSM 228

  Fly   262 SDEAGTGSFKSIASASVAKDYVESLHQNAKATLLYGKNNVQVLPKDVAEPMPGYLSLHQHIQTLT 326
            .|.....          |:|||||||||::||||:|||||.|.|.|..|.:||||||||....:|
Zfish   229 DDRPSLW----------ARDYVESLHQNSRATLLFGKNNVLVQPTDDMEAIPGYLSLHQTADLMT 283

  Fly   327 IKWTPNQLMNGYTEAEEAEDIDKDAFWAYALNINVDEIVYVHCHQSRGEDSGGTVILVGQDGVQR 391
            :||||||||||.||.    |.:|..:|.:|:.|.::||||:||||.  .||||||:||.|||:||
Zfish   284 LKWTPNQLMNGNTEF----DYEKSVYWDFAMTIRLEEIVYLHCHQQ--VDSGGTVVLVSQDGIQR 342

  Fly   392 PPIHFPEGGHMQQFLSCLETGLLPHGQLDPPLWSQRGIGKMFLWPRSMRRRILPSVMESV----D 452
            ||..||:|||:.|||:|||||||||||||||||||||.||:|  |: :|:|......||.    :
Zfish   343 PPFRFPKGGHLLQFLTCLETGLLPHGQLDPPLWSQRGKGKVF--PK-LRKRSPHGSCESFSDKDE 404

  Fly   453 ETPIDYVFRIVSKSRHEEFAATHSI---LDFVRSTPRRAQLSSCSTTGSSD------CSNKSLSI 508
            :...||||||:... .:||.|...|   ::..:.|||::..||||..||||      |::
Zfish   405 DEATDYVFRIIYPG-SQEFVAPELIEQAVNMWQPTPRKSSCSSCSQNGSSDGGLPNGCNH----- 463

  Fly   509 DQFPMESPLILQQQQQQQQQLLQAQSTSIEMVCSTMRRQIISRAFYGWLAYCRHLSTVRTHLSGL 573
            |:.|                        ::::|.||:.|||||||||||||||||||||||||.|
Zfish   464 DRAP------------------------LKLLCETMKHQIISRAFYGWLAYCRHLSTVRTHLSAL 504

  Fly   574 VHGRIT-PEMKADEE-GLTKERWQLLNVNGVLENATEFYRLVYFGGVQPELRQEVWPYLLGHYAF 636
            |:..|. |::..|.: ||:.:.|:....:.......|..||||:|||:|.||:||||:|||||.|
Zfish   505 VNATIVEPDIPYDAKGGLSADVWKSFLQDCSAYEEEELLRLVYYGGVEPSLRKEVWPFLLGHYHF 569

  Fly   637 GSTTEDRKKQDETCKHYYETTMSEWLAVDAIVQQREKEKTARAVAKLSSGSN----SGNDRTVRA 697
            ..:.|:||:.||..:..||.||||||..:|||:|||||:.|.|:||.:||::    |..|.|:..
Zfish   570 TMSPEERKEVDEQIRACYEQTMSEWLGCEAIVRQREKEQHAAALAKCASGASVDRGSRQDSTIST 634

  Fly   698 -------------ADLEAGGDLENEVFEDISDISDPGDLE---FDEQQQQQ-------------- 732
                         |...:..:...:||..:.:: ||.:.|   .||:.|.:
Zfish   635 DSSQSSNSDKQSHAGSHSDSNSSTQVFGSVDEV-DPIESEPKPKDEKPQPKIPNGALPNCTSSPD 698

  Fly   733 ------------QQQAECAVS----------GNHLTVKPIPR----------------------- 752
                        ...::|:.|          ||...::..|:
Zfish   699 SGHPSSRNFSVTSAMSDCSPSTEETSTQESKGNQPDIEEKPKEEQPENSSTTQNTDKAAITTQNK 763

  Fly   753 -AMKTSTDS--------GHVDESFNELDEPDE--------------------------------- 775
             .::||..|        ..:.::...|.||.|
Zfish   764 SKLQTSETSRAETDQIKDAISKNPTNLSEPKEDEVNAGAETRKSEVNKCEVQPSRDPAEESRSSE 828

  Fly   776 --------------------------------EDNKQKQQQDE---------------------- 786
                                            ||:|.:|...|
Zfish   829 SKQAEDADPVSLSIVDEDTKSNTEQEIGLKVNEDSKSQQSAPESTPEDVKTSQNLSSESNTKQET 893

  Fly   787 --KISE----------------------------------------------------------- 790
              |:||
Zfish   894 SLKVSEDSKCQPSAPESTSEAMTTSQNLSSESNTEQETGLKVNEDSKCQPSAPESTSEDMKTSQN 958

  Fly   791 --SES----------------------KLPDYRKLEE--------------QINQEPSCSASTAS 817
              |||                      ..|::.|..:              ::|::..|..|...
Zfish   959 ISSESNTEQETGLKVNKDSKSEQSAPKSTPEHMKTSQNLLSELNMEQATGLKVNEDSKCQPSAPE 1023

  Fly   818 ------------SYETVGPGEVHQRPNSDTRSVLS-----PEYLSADDLQLPD-----------D 854
                        |.|:....|...:.|.|::|..|     ||::......|.:           :
Zfish  1024 STPEAMKTSQNISSESNTQQETGLKVNKDSKSEQSAPKSTPEHMKTSQNLLSELNMEQATGLKVN 1088

  Fly   855 EDAVRPPPPP-----------------------------------AAAAVI-------------- 870
            ||:...|..|                                   .|.::|
Zfish  1089 EDSKCQPSAPESTLDDMKTSQNLSSGPQNVPQTAPQTISWDSEHNRARSIIKQMTESESESCGPL 1153

  Fly   871 --ITKASVDITNWERSPKAAEGDQM---------------SPLE--------EQAGESGGAGV-- 908
              ::|.|.|::  :.||.|.|.:::               :||.        ..|||....|:
Zfish  1154 TSLSKPSPDMS--DDSPSALEMEEIPSSVVYMSSETSMCRTPLTLARPVAPCIAAGEKSPMGMPA 1216

  Fly   909 -------------------------NMD---------ALQQPKSACASPASSNGGVYSSELLEQF 939
                                     .||         |:...|:..|||.||.|..||.||::.:
Zfish  1217 LELCMEPGVNTTPEGTDSALSEEEPEMDNLFPKPDSLAVTGDKNDIASPVSSIGTTYSQELVDLY 1281

  Fly   940 GLNLHRIEKDVQRCDRNYWYFANENLDKLRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESL 1004
            .||||||:|||||||||||||...||:||||::.:|||:|||:||:||||||:||||||.|||::
Zfish  1282 TLNLHRIDKDVQRCDRNYWYFTPANLEKLRNIMCSYVWQHLDIGYVQGMCDLLAPLLVILDDEAM 1346

  Fly  1005 SYSCFCKLMERMIENFPSGGAMDMHFANMRSLIQILDSEMYDLMDSNGDYTHFYFCYRWFLLDFK 1069
            ::|||.:||:||.:|||.|||||.|||||||||||||||:::||..|||||||||||||||||||
Zfish  1347 AFSCFTELMKRMNQNFPHGGAMDTHFANMRSLIQILDSELFELMQQNGDYTHFYFCYRWFLLDFK 1411

  Fly  1070 RELVYDDVFATWEVIWAAKHIASGHFVLFLALALLETYRDIILSNSMDFTDVIKFFNEMAERHNA 1134
            ||:||||||:.||.||||::.:|.|||||:||||:|.||||||.|:|||||:|||||||||||:.
Zfish  1412 REMVYDDVFSVWETIWAARYASSEHFVLFIALALVELYRDIILENNMDFTDIIKFFNEMAERHDV 1476

  Fly  1135 QSVLQLARSLVLQLQMIIENK 1155
            ..:|.:||.||.::|::||||
Zfish  1477 PKLLVMARDLVHKVQILIENK 1497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_608395.6	RUN_SGSM1_like	21..214	CDD:439049	83/197 (42%)
		PH_RUTBC	292..466	CDD:275431	105/177 (59%)
		TBC	923..1087	CDD:214540	119/163 (73%)
sgsm1b	XP_073770421.1	None