Protein Alignment tbc and sgsm2

DIOPT Version :9

• Sequence 1: NP_001285494.1
• Gene: tbc / 318059
• FlyBaseID: FBgn0052506
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: XP_002935339.2
• Gene: sgsm2 / 100494226
• XenbaseID: XB-GENE-6050632
• Length: 1058
• Species: Xenopus tropicalis
• Alignment Length: 1196
• Identity: 527/1196 - (44%)
• Similarity: 692/1196 - (57%)
• Gaps: 184/1196 - (15%)

  Fly     5 NADGSDYKERLIASVKKEVKQLMEEAVTKKYVHEESSSVTSLCGAVEACLSQGLRRRALGLFKTS 69
            |......||:|:.:|||||||:||||||:|:|||:||.:.:|||.|||||...|:|||.|..::.
 Frog     2 NCSDDSAKEKLLWNVKKEVKQIMEEAVTRKFVHEDSSHIIALCGVVEACLLHLLKRRAAGFLRSD 66

  Fly    70 STTALLHKIAKSCPEAEHISKLVQEIEASDPSKRSSSSSDSFQRPPMLKKSSSNSMSTGTNAAAS 134
            ...||..|:||:|..|..|.|.||:::.....:::.||...     .||:.||   :||
 Frog    67 KVAALFMKVAKTCATAADICKKVQDLQQQVEGRKNISSGQE-----SLKRQSS---TTG------ 117

  Fly   135 TSSASASISVSASTSSMSLASMKYLWIRLALYEKRLTKIIEYLVSNASSFYDRDSLVADSDYGSI 199
                        .|.:::..::|::|:|.||.||.|.||::|:|.|.|.:|:::||::|...|.|
 Frog   118 ------------RTVTLTPQALKHIWVRTALIEKVLDKIVQYIVDNCSKYYEKESLMSDPVCGPI 170

  Fly   200 LSSLLVGPCALEFTRAKTADHYWTDPHADELVQRHRISSCR-RSSSTCSRPAIINFKRSLNTSSD 263
            |::|||||||||:|:.||||||||||.||||||||||.... |..|.|.|||:...||.
 Frog   171 LAALLVGPCALEYTKLKTADHYWTDPSADELVQRHRIHGAHSRQDSPCKRPALSIKKRH------ 229

  Fly   264 EAGTGSFKSIASASVAKDYVESLHQNAKATLLYGKNNVQVLPKDVAEPMPGYLSLHQHIQTLTIK 328
              .:||......|:.|::||||||||::..||||||||.|.||:..|.:||||||||..:.||:|
 Frog   230 --SSGSMSEDKFAASAREYVESLHQNSRTHLLYGKNNVLVQPKEDKEAIPGYLSLHQSGENLTLK 292

  Fly   329 WTPNQLMNGYTEAEEAEDIDKDAFWAYALNINVDEIVYVHCHQSRGEDSGGTVILVGQDGVQRPP 393
            ||||||:||.....|   ::|..||.|||.:.:.:||.:||||.  .||.||::||.|||:||||
 Frog   293 WTPNQLLNGTLGDSE---LEKSVFWDYALIVPISQIVCIHCHQQ--PDSRGTLVLVSQDGIQRPP 352

  Fly   394 IHFPEGGHMQQFLSCLETGLLPHGQLDPPLWSQRGIGKMFLWPRSMRRRILPSVMESVD------ 452
            :|||.|||:..||||||.||||.|||:||||||||.||:|  |:..:|.   |..:|||
 Frog   353 LHFPPGGHLLAFLSCLENGLLPRGQLEPPLWSQRGKGKVF--PKLRKRN---SSNKSVDFDDNVV 412

  Fly   453 -ETPIDYVFRIV-SKSRHEEFAATHSILDFVRSTP----------RRAQLSSCSTTGSSDCSNKS 505
             |...||||||: :..:|:.....:..|...||..          ..|.||..|:...:...:..
 Frog   413 EEITTDYVFRIIYAGHKHDNITINYHHLAASRSVSVDDDEEEEDRLHAMLSMISSRNLTAPKSMK 477

  Fly   506 LSIDQFPMES------PLILQQQQQQQQQLLQAQSTS-----------------IEMVCSTMRRQ 547
            .|.|...|:.      |..|.:...|....|...:.|                 ::::|..|::|
 Frog   478 ESGDVIEMQGFGANLLPWQLNEFCSQGSSCLSCSTGSSPYDIPSCCSCVHDRAPLKLLCENMKKQ 542

  Fly   548 IISRAFYGWLAYCRHLSTVRTHLSGLV-HGRITPEMKADEE-GLTKERWQLLNVNGVLENATEFY 610
            |:||||||||||||||||||||||.|| |..|.|:...|.. |||||.|.....:.......|..
 Frog   543 IVSRAFYGWLAYCRHLSTVRTHLSALVNHSIIPPDKPTDASGGLTKEVWSKYEKDMKNYKELELL 607

  Fly   611 RLVYFGGVQPELRQEVWPYLLGHYAFGSTTEDRKKQDETCKHYYETTMSEWLAVDAIVQQREKEK 675
            ||||:|||:.|:|:||||:|||||.||.|.::..:.||.....|:..|:||.|.:.||:|||||.
 Frog   608 RLVYYGGVEHEIRKEVWPFLLGHYKFGMTKKEMDRVDEAIAARYQKVMAEWKACEVIVKQREKES 672

  Fly   676 TARAVAKLSSGSNSGNDRTVRAADLEAGGDLENEVFEDISDISDPGDLEFDEQQQQQQQQAECAV 740
            .:...|||||||:.  |..|:.. :.....:.|:||....:| |..|.:......:....|...|
 Frog   673 HSAIYAKLSSGSSI--DSHVQRL-IHRDSTISNDVFMSTEEI-DITDRDLKGHNGKASNLASTPV 733

  Fly   741 SGNHLTVKPIPRAMKTSTDSGHVDESFNELDEPDEEDNKQKQQQDEKISESESKLPDYRKLEEQI 805
            :   |.|.|               :...|.|.||                  |.||..|..
 Frog   734 A---LAVDP---------------QQSVEFDSPD------------------SGLPSSRNY---- 758

  Fly   806 NQEPSCSASTASSYETVGPGEVHQRPNSDTRSVLSPEYLSADDLQ-LPDDEDAVRPPPPPAAAAV 869
                                       |.|..:||    |.||.| :..:|:............|
 Frog   759 ---------------------------SVTSGILS----SIDDGQSICFEEEESNTESDRTEMTV 792

  Fly   870 IITKASVDITNWERSPKAAEGDQMSPLEEQAGESGGAGVNMDALQQPKSACASPASSNGGVYSSE 934
            ..|:.|..|...:.|  .:|....|.|:           .::..:...|.|  |.|     |:.|
 Frog   793 CPTRKSKGILKMQES--ISEEQLSSQLD-----------YLNTAEDISSMC--PTS-----YTIE 837

  Fly   935 LLEQFGLNLHRIEKDVQRCDRNYWYFANENLDKLRNVISTYVWEHLDVGYMQGMCDLVAPLLVIF 999
            ||:...||||||:|||||||||||||.:|||:||||::.:|||||||:||:||||||:|||:|:.
 Frog   838 LLDTIALNLHRIDKDVQRCDRNYWYFTDENLEKLRNIMCSYVWEHLDIGYVQGMCDLLAPLMVVL 902

  Fly  1000 DDESLSYSCFCKLMERMIENFPSGGAMDMHFANMRSLIQILDSEMYDLMDSNGDYTHFYFCYRWF 1064
            |::.|:||||.:||:||.:|||:|||||.|||||||||||||||:::||..||||||||||||||
 Frog   903 DNDLLAYSCFTQLMKRMSQNFPNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWF 967

  Fly  1065 LLDFKRELVYDDVFATWEVIWAAKHIASGHFVLFLALALLETYRDIILSNSMDFTDVIKFFNEMA 1129
            ||||||||:|:||||.|||||||:.|:|.|||||:||||:|.||:|:..|:|||||:||||||||
 Frog   968 LLDFKRELLYEDVFAVWEVIWAARLISSEHFVLFIALALVEVYREIVRDNNMDFTDIIKFFNEMA 1032

  Fly  1130 ERHNAQSVLQLARSLVLQLQMIIENK 1155
            |.|:||.:|::||.||.::|.:||||
 Frog  1033 EHHDAQLILRIARDLVHKVQTLIENK 1058

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_001285494.1	RUN	45..218	CDD:280855	65/172 (38%)
		PH_RUTBC	292..466	CDD:275431	100/181 (55%)
		TBC	923..1087	CDD:214540	118/163 (72%)
sgsm2	XP_002935339.2	RUN	42..189	CDD:280855	65/172 (38%)
		PH_RUTBC	256..427	CDD:275431	100/180 (56%)
		TBC	<846..1013	CDD:214540	126/166 (76%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	299	1.000	Domainoid score	I1424
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	958	1.000	Inparanoid score	I332
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D171826at2759
OrthoFinder	1	1.000	-	-		FOG0002045
OrthoInspector	1	1.000	-	-		mtm9377
Panther	1	1.100	-	-	O	PTHR22957
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1347
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.160