Protein Alignment tbc and tbc1d12b

DIOPT Version :9

• Sequence 1: NP_001285494.1
• Gene: tbc / 318059
• FlyBaseID: FBgn0052506
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: XP_005169505.1
• Gene: tbc1d12b / 100332088
• ZFINID: ZDB-GENE-121214-108
• Length: 771
• Species: Danio rerio
• Alignment Length: 631
• Identity: 128/631 - (20%)
• Similarity: 203/631 - (32%)
• Gaps: 222/631 - (35%)

  Fly   701 EAGGDLENEVFEDISDISDPGDLEFDEQQQQQQ------QQAECAVSGNH----LTVKPIPRAMK 755
            |||..||.:..|.:..:        |:.::...      |.:||.....|    .:..|:..:::
Zfish   161 EAGESLETQAGETLEAL--------DQAERSSTDHCLGLQSSECNEGKLHRRSSTSPSPLKHSLR 217

  Fly   756 T-------STDSGHV--------DESFNELDEPDE----------------------EDN----- 778
            |       :|||..:        ||:|:..|.||:                      .||
Zfish   218 TFSSSTFLNTDSASLSPNDDDDEDETFSTSDRPDDLRFMDVSLKSRNTYEISRRQSAPDNIPGVL 282

  Fly   779 ---------------------------KQKQQQDE-------KISESESKLPDYRKLEEQINQEP 809
                                       ||::.|..       |:...||...|.:.::::.|...
Zfish   283 SVAAVDLTLGQRKQGISDIFSRSLFTRKQREAQSAPGWKLFGKVPLRESPPKDSKTIQQESNPGN 347

  Fly   810 SCSAST-----ASSYE--TVGPGEVHQRPNSDTRSVLSPEYLSADDLQLPDDEDAVRPPPPPAAA 867
            ..|.||     :..||  ....|:....|....|..|..|.||...|.|.|     ||...||.:
Zfish   348 LTSVSTPNLLSSGEYEAKVCKSGQSPSLPAQSRRKNLEFEPLSTTALILED-----RPANLPAKS 407

  Fly   868 A-----------VIITKASVDITNWERSPKAAE--GDQMSPLEEQAGESGGAGV--NMDALQQPK 917
            .           .::.:|.      :|..|.|:  ..||....:|......|.|  |.:.|...:
Zfish   408 EEEAQRHRQEYDEMVAEAK------KRELKEAQKKKKQMKERFKQEESIANAMVVWNTEILPNWE 466

  Fly   918 SACAS-----------PASSNGGVYS----------SELLEQFGLNLHR--------------IE 947
            |...:           |.:..|.|:|          |:|.|.|   |.|              ||
Zfish   467 SMRGTRRVRDLWWQGLPPNVRGKVWSLAVGNELNITSDLYEIF---LSRAKERWKSFRETGSEIE 528

  Fly   948 KDVQRCDR----------------NYWYF--ANENLDKLRNVISTYVWEHLDVGYMQGMCDLVAP 994
            .||...||                :.:.|  .....|.|.:|:..|.....||||:||| ..:|.
Zfish   529 SDVDSADRESSLDLIKLDISRTFPSLFIFQKGGPYHDLLHSVLGAYTCYRPDVGYVQGM-SFIAA 592

  Fly   995 LLVIFDDESLSYSCFCKLM-------------ERMIENFPSGGAMDMHF-ANMRSLIQILDSEMY 1045
            :|::..:|:.::..|..|:             |.|::.|   .|.::.| .|:..|.....|  |
Zfish   593 VLILNLEEADAFIAFANLLNKPCQMAFFRVDHELMLKYF---AAFEVFFEENLPRLFNHFKS--Y 652

  Fly  1046 DLMDSNGDYTHFYFCYRWFLLDFKRELVYDDVFATWEVIWAAKHIASGHFVLF-LALALLETYRD 1109
            :|       |...:...|....:.:.|..|.....|:|.     ...|...|| ..|.:|..|.:
Zfish   653 NL-------TPDLYLIDWIFTLYAKSLPLDVACRVWDVF-----CRDGEEFLFRTGLGILRLYEE 705

  Fly  1110 IILSNSMDFTDVIKFFNEMAERHNAQSVLQLARSLVLQLQMIIENK 1155
            ::|  .|||....:|...:.:....:.:.    |.:...|||..|:
Zfish   706 LLL--QMDFIHSAQFLTRLPDDTPPERLF----SCIASTQMISSNR 745

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_001285494.1	RUN	45..218	CDD:280855
		PH_RUTBC	292..466	CDD:275431
		TBC	923..1087	CDD:214540	49/219 (22%)
tbc1d12b	XP_005169505.1	TPX2	407..>451	CDD:284337	7/49 (14%)
		TBC	478..708	CDD:214540	55/250 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900