DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tbc and tbc1d2b

DIOPT Version :9

Sequence 1:	NP_001285494.1	Gene:	tbc / 318059	FlyBaseID:	FBgn0052506	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	XP_002666912.2	Gene:	tbc1d2b / 100330777	ZFINID:	ZDB-GENE-100922-148	Length:	946	Species:	Danio rerio

Alignment Length:	787	Identity:	161/787 - (20%)
Similarity:	264/787 - (33%)	Gaps:	247/787 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   452 DETPIDYVFRIVSKSRHEEFAATHSILDFVRSTPRRAQLSSCSTTGSSDCSNKSLSIDQFPMESP 516
            |..|.|...|  ..|.|...::..|...|....|.:.:....|.:|..:.|.:|..::....:..
Zfish   253 DPAPSDCQHR--ESSSHFNRSSIGSAFTFDFRNPSKIKRPFHSGSGKPNHSAESSPVEYNETKIS 315

  Fly   517 LILQQQQQQQQQLLQAQSTSIEMVCSTMRRQIISRAFYGWLAYCRHLSTVRTHLSGLVHGRITPE 581
            .:..:.|.||:::.|.|.                                             .|
Zfish   316 KLQLRIQSQQEEISQLQE---------------------------------------------QE 335

  Fly   582 MKADEE-GLTKERWQLLNVNGVLENATEFYRLVYFGGVQPELR--QEVWPYLLG---HY-----A 635
            .|..|| |..||..:||                     |..||  |..||..:|   ||     .
Zfish   336 NKLREELGSQKELVRLL---------------------QKTLRSAQCDWPSTVGPHNHYLEENEV 379

  Fly   636 FGSTTEDRKKQDETCKHYYETTMSEWLAVDAIVQQREKEKTARAVAKLSSGSNSGNDR------T 694
            ..:.||...:..:.|.|      .|.||:       |||...:.:..|.......|::      |
Zfish   380 DKALTERDTQIKDLCSH------MEKLAL-------EKESLQQELKGLKIKVGEINEQLGMLMET 431

  Fly   695 VRAADLEAGGDLENEVFEDISDISDPGDLEFDEQQQQQQQQAECAVSGNHLTVKPIPRAMKTSTD 759
            ::|.|         ||...:|..|..|          :.|.|||    |..:|....:.:.|..|
Zfish   432 IQAKD---------EVIMKLSQPSGEG----------ETQSAEC----NSPSVTREQQELNTLKD 473

  Fly   760 S--GH------VDESFNELDEPDEEDNKQKQQQDEKISESESKL----PDYRKLEEQINQEPSCS 812
            |  |:      :::...||.........:::..:.|.:..|:||    ..|..|.::: :.|.||
Zfish   474 SLQGYKSQNKFLNKEIIELTVLRRNAESREKLLEAKYNSLEAKLCQVESKYLVLLQEV-KSPVCS 537

  Fly   813 ASTASSYETVGPGEVHQRPNSDTRSVLSPEYLSADDLQLPDDEDAVRPPPPPAAAAVIITKASVD 877
            :|     |....|:|..|             |..|.||:...:....|...|.|.      :..|
Zfish   538 SS-----EQTHSGDVITR-------------LLEDALQVESTDQQEHPVLKPNAV------SEYD 578

  Fly   878 ITNWERSPKAAEGDQMSPLEEQ-----------AGESGGAGVNMD---ALQQPKSACASP---AS 925
            |..::..|:  |.|:...||.:           ..:.....|..|   |:...:....||   |.
Zfish   579 IYGFKTVPE--EEDEEEKLEAKKRALDLKSLSLTDQETSVRVKWDNYLAITMNREMVRSPDLKAL 641

  Fly   926 SNGGV---------------------------YSSELL----EQFGLNLHRIEKDVQRCDRNYWY 959
            ..|||                           |...||    ::......:||.|:.|...|..:
Zfish   642 MRGGVPHIHRSKVWSWCVSFHVKKMRDCQPKDYYHNLLCMANDKPNPACKQIELDLLRTLPNNKH 706

  Fly   960 FA---NENLDKLRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKLMERMIENFP 1021
            ::   ::.:.|||||:..:.|.:.|:||.||:..|.|..|:..|.|. ::.|...::|..:.
Zfish   707 YSSPDSDGIQKLRNVLLAFSWRNPDIGYCQGLNRLAAIALLYLDQED-AFWCLVAIVEVFMP--- 767

  Fly  1022 SGGAMDMHFANMRSLI--QILDSEMYDLMDSNGDYTHFYF----------CYRWFLLDFKRELVY 1074
                   |....::|:  |:......|||.......|.:|          .:.|||:.|...:|.
Zfish   768 -------HDYYTKTLLGSQVDQRVFKDLMYEKLPRLHAHFEHYKVDFSLITFNWFLVVFVDSVVS 825

  Fly  1075 DDVFATWEVIWAAKHIASGHFVLF-LALALLETYRDIILSNSMDFTDVIKFFNEMAERHNAQSVL 1138
            |.:|..|:     ..:..|..::| .||||.: |::.......|...:.|:.     |:..:::|
Zfish   826 DILFKIWD-----SFLYEGPKIIFRFALALFK-YKEEEFLKLQDPMTIFKYL-----RYFTRTIL 879

  Fly  1139 QLARSLV 1145
            . ||.|:
Zfish   880 D-ARKLM 885

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_001285494.1	RUN	45..218	CDD:280855
		PH_RUTBC	292..466	CDD:275431	4/13 (31%)
		TBC	923..1087	CDD:214540	47/212 (22%)
tbc1d2b	XP_002666912.2	PH_TBC1D2A	37..137	CDD:269966
		PH	37..129	CDD:278594
		CtIP_N	307..415	CDD:287457	33/186 (18%)
		TPR_MLP1_2	313..434	CDD:285204	36/199 (18%)
		USP8_interact	317..>359	CDD:286082	17/107 (16%)
		TBC	643..859	CDD:214540	52/232 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900